Abstract
In this study, experimental electroporation model with human aorta tissue is compared with computational modeling. The segments in native state of the aorta are treated by electroporation method through a series of electrical impulses from 50 to 2500 V/cm. The Pennes Bioheat equation is used to solve heat transfer problems. Different conductivity values are used in order to fit the experimental results. It has been shown that there are a smaller number of vascular smooth muscle cells (VSMC) nuclei at the tunica media, while the elastic fibers morphology is maintained 24 h after electroporation. Additionally we studied with computational model of plaque formation and progression the reduction of the plaque size with electroporation. The initial results have been shown plaque reduction for carotid artery case. Future studies are necessary for design of a new device for in vivo ablation with electroporation of plaque stenosis.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Deng ZS, Liu J (2001) Blood perfusion-based model for characterizing the temperature fluctuations in living tissue. Phys A Stat Mech Appl 300:521–530
Filipovic N, Rosic M, Tanaskovic I, Milosevic Z, Nikolic D, Zdravkovic N, Peulic A, Fotiadis D, Parodi O (2012) ARTreat project: three-dimensional numerical simulation of plaque formation and development in the arteries. IEEE Trans Inf Technol Biomed 16(2):272–278
Filipovic N, Teng Z, Radovic M, Saveljic I, Fotiadis D, Parodi O (2013) Computer simulation of three dimensional plaque formation and progression in the carotid artery. Med Biol Eng Comput. doi:10.1007/s11517-012-1031-4
Filipovic N, Saveljic I, Jovicic N, Tanaskovic I, Zdravkovic N (2016) Computational and experimental model of electroporation for human aorta. Acta Bioeng Biomech. doi:10.5277/ABB-00444-2015-02
Hamilton WA, Sale JH (1967) Effects of high electri fields of microorganisms. II. Mechansims of action of the lethal effect. Biochem Biophys Acta 148:789–800
Kedem O, Katchalsky A (1958) Thermodynamic analysis of the permeability of biological membranes to non-electrolytes. Biochim Biophys 27:229–246
Kedem O, Katchalsky A (1961) A physical interpretation of the phenomenological coefficients of membrane permeability. J Gen Physiol 45:143–179
Maor E, Ivorra A, Leor J, Rubinsky B (2007) The effect of irreversible electroporation on blood vessels. Technol Cancer Res Treat 6(4):307–312. ISSN 1533-0346
Sale JH, Hamilton WA (1967) Effect of high electrical fields on microorganisms. I. Killing of bacteria and yeast. Biochim Biophys Acta 148:781–788
Sale AJH, Hamilton WA (1968) Effects of high electri fields on microorganisms III. Lysis of erythrocytes and protoplasts. Biochim Biophys Acta 163:37–43
Acknowledgements
This study was funded by grants from Serbian Ministry of Education, Science and Technological Development III41007, ON174028 and HORIZON2020 689068 SMARTool project.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG
About this paper
Cite this paper
Filipovic, N., Saveljic, I., Tanaskovic, I. (2018). Computer Simulation of Electroporation and Drug Transport Through Membranes. In: Gefen, A., Weihs, D. (eds) Computer Methods in Biomechanics and Biomedical Engineering. Lecture Notes in Bioengineering. Springer, Cham. https://doi.org/10.1007/978-3-319-59764-5_20
Download citation
DOI: https://doi.org/10.1007/978-3-319-59764-5_20
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-59763-8
Online ISBN: 978-3-319-59764-5
eBook Packages: EngineeringEngineering (R0)