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Cerebellar Transplantation: A Potential Model to Study Repair and Development of Neurons and Circuits in the Cerebellum

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Development of the Cerebellum from Molecular Aspects to Diseases

Part of the book series: Contemporary Clinical Neuroscience ((CCNE))

Abstract

Neuronal transplantation offers the advantages of a unique experimental situation that allows the in vivo study of cell-to-cell interactions between embryonic and adult neural partners. This approach was developed to study the possibility to replace missing neurons in pathological situations. In our model, the cerebellum with spontaneous mutations, Purkinje cell degeneration, nervous, Lurcher (pcd, nr, Lc) affecting Purkinje cells (PCs), this substitution occurs. Embryonic PCs can trigger in adult Bergmann fibers molecular changes required for migration and ultimate synaptic integration of the former, although this integration is not complete because the full contingent of efferent projections failed to establish. The grafting approach evolved as a suitable tool that, through heterotopic and heterochronic transplants, allowed the investigation of the role of cellular and molecular microenvironment on the acquisition of neuronal phenotypes and on the differential ability to regenerate amputated axons of specific populations of central neurons. Finally, new approaches developed in the twenty-first century, with the advent of stem cells and cell reprogramming, are mentioned and some of the earliest cerebellar trials with these pluripotent cells discussed.

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Authors and Affiliations

  1. INSERM UMR S968, Institut de la Vision, Paris, France

    Constantino Sotelo

  2. Université Pierre et Marie Curie, Sorbonne Universités, Paris, France

    Constantino Sotelo

  3. UMR 7210, CNRS, Paris, France

    Constantino Sotelo

  4. Instituto de Neurociencias de la Universidad Miguel Hernández–Consejo Superior de Investigaciones Científicas, San Juan de Alicante, 03550, Spain

    Constantino Sotelo

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  1. Constantino Sotelo
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Correspondence to Constantino Sotelo .

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  1. Department of Human Anatomy and Cell Science, The Children’s Hospital Research Institute of Manitoba (CHRIM), Max Rady College of Medicine, Rady Faculty of Health Science, University of Manitoba, Winnipeg, MB, Canada

    Hassan Marzban

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Sotelo, C. (2017). Cerebellar Transplantation: A Potential Model to Study Repair and Development of Neurons and Circuits in the Cerebellum. In: Marzban, H. (eds) Development of the Cerebellum from Molecular Aspects to Diseases. Contemporary Clinical Neuroscience. Springer, Cham. https://doi.org/10.1007/978-3-319-59749-2_22

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