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Can Cerebellar Neurodevelopmental Disorders Affect Behavioral Disorders or Vice Versa?

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Development of the Cerebellum from Molecular Aspects to Diseases

Part of the book series: Contemporary Clinical Neuroscience ((CCNE))

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Abstract

Recent investigations have been focused on understanding the role of the cerebellum in non-motor behaviors and of the cerebellar dysfunction in neurodevelopmental, neurobehavioral, and schizo-affective disorders . Non-motor behaviors, including emotion, cognition, and social behavior, seem to be modified by impairment of the cerebellar structure-function relationship. Clinically, these behavioral defects have been observed in patients with autism spectrum disorders (ASD), attention deficit hyperactivity disorder (ADHD), and schizophrenia. These behavioral outcomes have been demonstrated to be associated with prenatal and/or early postnatal damages of cerebro-cerebellar circuits. Concerning to the essential role of the cerebellum in early neurodevelopment, understanding the association between cerebellar injury and long-term alteration in behavior is highly crucial. This chapter’s attempts are to summarize the recent evidence of involvement of the cerebellum in neurodevelopment and behavior and that both these views remain to be revised for declaration of the paradoxical relationship between cerebellar function and behavioral despair, as well as neurodevelopmental disorders including ASD and ADHD.

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  1. Department of Toxicology-Pharmacology, Faculty of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran

    Seyed Soheil Saeedi Saravi

  2. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, P.O. Box: 13145-784, Tehran, Iran

    Seyed Soheil Saeedi Saravi & Ahmad Reza Dehpour

  3. Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran

    Seyed Soheil Saeedi Saravi & Ahmad Reza Dehpour

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  1. Department of Human Anatomy and Cell Science, The Children’s Hospital Research Institute of Manitoba (CHRIM), Max Rady College of Medicine, Rady Faculty of Health Science, University of Manitoba, Winnipeg, MB, Canada

    Hassan Marzban

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Saeedi Saravi, S.S., Dehpour, A.R. (2017). Can Cerebellar Neurodevelopmental Disorders Affect Behavioral Disorders or Vice Versa?. In: Marzban, H. (eds) Development of the Cerebellum from Molecular Aspects to Diseases. Contemporary Clinical Neuroscience. Springer, Cham. https://doi.org/10.1007/978-3-319-59749-2_17

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