Abstract
Acute fatty liver of pregnancy is a genetic disorder worsened during late pregnancy when heightened lipid metabolism contributes to accumulation of fatty acids in the liver. Symptoms are mostly attributable to liver and kidney damage and may include liver failure of hepatic encephalopathy. Prompt delivery of the fetus, with urgent cesarean delivery in severe cases, is key to recovery.
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References
Knight M, Nelson-Piercy C, Kurinczuk JJ, Spark P, Brocklehurst P, UK Obstetric Surveillance System. A prospective national study of acute fatty liver of pregnancy in the UK. Gut. 2008;57:951–6.
Usta IM, Barton JR, Amon EA, Gonzalez A, Sibai BM. Acute fatty liver of pregnancy: an experience in the diagnosis and management of fourteen cases. Am J Obstet Gynecol. 1994;171:1342–7.
Browning MF, Levy HL, Wilkins-Haug LE, Larson C, Shih VE. Fetal fatty acid oxidation defects and maternal liver disease in pregnancy. Obstet Gynecol. 2006;107(1):115–20.
Ibdah JA, Bennett MJ, Rinaldo P, Zhao Y, Gibson B, Sims HF, Strauss AW. A fetal fatty-acid oxidation disorder as a cause of liver disease in pregnant women. N Engl J Med. 1999;340:1723–31.
Gracia PV, Lavergne JA. Acute fatty liver of pregnancy. Int J Gynaecol Obstet. 2001;72:193–5.
Liu G, Shang X, Yuan B, Han C, Wang Y. Acute fatty liver of pregnancy: analysis on the diagnosis and treatment of 15 cases. J Reprod Med. 2016;61:282–6.
Pereira SP, O’Donohue J, Wendon J, Williams R. Maternal and perinatal outcome in severe pregnancy-related liver disease. Hepatology. 1997;26:1258–62.
Baldwin GS. Do NSAIDs contribute to acute fatty liver of pregnancy? Med Hypotheses. 2000;54:846–9.
Castro MA, Fassett MJ, Reynolds TB, Shaw KJ, Goodwin TM. Reversible peripartum liver failure: a new perspective on the diagnosis, treatment, and cause of acute fatty liver of pregnancy, based on 28 consecutive cases. Am J Obstet Gynecol. 1999;181:389–95.
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Li, A., Tao, W. (2018). Acute Fatty Liver. In: Mankowitz, S. (eds) Consults in Obstetric Anesthesiology. Springer, Cham. https://doi.org/10.1007/978-3-319-59680-8_4
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DOI: https://doi.org/10.1007/978-3-319-59680-8_4
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