Abstract
Successful drug discovery requires deep understanding of the mechanisms of diseases, the full biological context of the drug target and biochemical mechanisms of drug action. It should involve a multilevel conceptual framework which would allow the integration and variation of parameters and constants within the biological system with high precision. Systems computational biology approach, as a thorough, quantitative and qualitative, interrogation of biological processes within the physiological milieu in which they function, provides a new paradigm to study the combined behavior of interacting components through the integration of experimental, mathematical and computational methods.
Mathematics takes us to the region of absolute necessity…
Bertrand Russell
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References
Heitman LH, Mulder-Krieger T, Spanjersberg RF, von Frijtag Drabbe Künzel JK, Dalpiaz A, Ijzerman AP (2006) Allosteric modulation, thermodynamics and binding to wild-type and mutant (T277A) adenosine A1 receptors of LUF5831, a novel nonadenosine-like agonist. Br J Pharm 147(5):533–541
Kenakin T (2004) Principles: receptor theory in pharmacology. Trends Pharm Sci 25:186–192
Koshland DE Jr, Némethy G, Filmer D (1966) Comparison of experimental binding data and theoretical models in proteins containing subunits. Biochemistry 5(1):365-368
Monod J, Wyman J, Changeux JP (1965) On the nature of allosteric transitions: a plausible model. J Mol Biol 12:88–118
Stockton JM, Birdstall NJM, Burgen ASV, Hulme EC (1983) Modification of the binding-properties of muscarinic receptors by gallamine. Mol Pharm 23:551–557
Strachan RT, Ferrara G, Roth BL (2006) Screening the receptorome: an efficient approach for drug discovery and target validation. Drug Disc Today 11:708–716
Tucek S, Musilkova J, Nedoma J, Proska J, Shelkovnikov S, Vorlicek J (1990) Positive cooperativity in the binding of alcuronium and N-methylscopolamine to muscarinic acetylcholine receptors. Mol Pharm 38:674–680
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Miftahof, R.N. (2017). Pharmacology of Gastric Dysmotility. In: Biomechanics of the Human Stomach. Springer, Cham. https://doi.org/10.1007/978-3-319-59677-8_9
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DOI: https://doi.org/10.1007/978-3-319-59677-8_9
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