Abstract
After the colonization of the gastrointestinal tract by NCSCs is complete, a complex network of neuronal and glial cells arranged in interconnected ganglia is generated. Different subtypes of ganglionic cells, based on a combination of their morphology, neurochemical coding, electrophysiological responses, connections, projections and function are identified in the enteric nervous system. Morphofunctional and projectile classification reflects on intrinsic primary afferent, ascending (orally)/descending (aborally) inter-, motor, intestinofugal, secretomotor and vasomotor neurons. By contrast electrophysiological taxonomy is based mainly on firing pattern characteristics. Thus S–type neurons exhibit brief action potentials and lack a prolonged slow after-hyperpolarization phase, whilst AH–type neurons show prominent long lasting (up to 20 s) hyperpolarization dynamics. The neuro-chemo-functional division into cholinergic, nitrergic, serotonergic, etc becomes superfluous because neurons co-localise and co-release multiple neurotransmitters and simultaneously exert excitatory and/or inhibitory effects.
The mathematics is not there till we put it there.
Arthur Eddington
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Miftahof, R.N. (2017). Intrinsic Regulatory and Effector Systems. In: Biomechanics of the Human Stomach. Springer, Cham. https://doi.org/10.1007/978-3-319-59677-8_8
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