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Biomedical Applications of Anisotropic Gold Nanoparticles

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Part of the book series: Nanostructure Science and Technology ((NST))

Abstract

Synthesized colloidal suspensions of gold nanoparticles (GNP) have been around since the early 1950s. Since that time there has been an extremely large body of work dedicated to investigating both the chemical and physical properties of these fascinating materials. This work has by no means been limited to nanospheres, but over the last ~20 years included a wide variety of morphologies including nanorods, nanocubes, nanoshells, and nanocages to name a few. There has been much effort spent on functionalizing these nanomaterials for the purpose of novel nanotechnology-driven approaches to medicinal and biological challenges. Gold nanoparticles continue to be of interest due to their interesting optical properties , sizes, photothermal properties and long-term stability. More recently, there has been a more concerted effort to better understand the growth mechanism of the gold nanoparticles and to discover more efficient and/or greener alternatives for the synthesis of these materials. We cannot begin to provide a truly comprehensive explanation of all of the published work within the gold nanoparticle field in this chapter and so have chosen to outline a few key areas of study.

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References

  1. Fedlheim, D.L., and C.A. Foss. 2001. Metal nanoparticles: Synthesis, characterization, and applications. CRC press.

    Google Scholar 

  2. Williamson, S.J., and H.Z. Cummins. 1983. Color Research & Application 10 (2): 2.

    Google Scholar 

  3. Dreaden, E.C., A.M. Alkilany, X. Huang, C.J. Murphy, and M.A. El-Sayed. 2012. Chemical Society Reviews 41 (7): 2740–2779.

    Article  CAS  Google Scholar 

  4. Mie, G. 1908. Annalen der Physik 330 (3): 377–445.

    Article  Google Scholar 

  5. Murphy, C.J., T.K. Sau, A.M. Gole, C.J. Orendorff, J. Gao, L. Gou, S.E. Hunyadi, and T. Li. 2005. The Journal of Physical Chemistry B 109 (29): 13857–13870.

    Google Scholar 

  6. Stone, J., S. Jackson, and D. Wright. 2011. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 3 (1): 100–109.

    Google Scholar 

  7. Turkevich, J., P.C. Stevenson, and J. Hillier. 1951. Discussions of the Faraday Society 11: 55–75.

    Article  Google Scholar 

  8. Brust, M., M. Walker, D. Bethell, D.J. Schiffrin, and R. Whyman. 1994. Journal of the Chemical Society, Chemical Communications (7): 801–802.

    Google Scholar 

  9. Martin, B.R., D.J. Dermody, B.D. Reiss, M. Fang, L.A. Lyon, M.J. Natan, and T.E. Mallouk. 1999. Advanced Materials 11 (12): 1021–1025.

    Article  CAS  Google Scholar 

  10. Yu, Y.-Y., S.-S. Chang, C.-L. Lee, and C.C. Wang. 1997. The Journal of Physical Chemistry B 101 (34): 6661–6664.

    Article  CAS  Google Scholar 

  11. Kim, F., J.H. Song, and P. Yang. 2002. Journal of the American Chemical Society 124 (48): 14316–14317.

    Article  CAS  Google Scholar 

  12. Connor, E.E., J. Mwamuka, A. Gole, C.J. Murphy, and M.D. Wyatt. 2005. Small 1 (3): 325–327.

    Article  CAS  Google Scholar 

  13. Yu, C., and J. Irudayaraj. 2007. Analytical Chemistry 79 (2): 572–579.

    Google Scholar 

  14. Norman, R.S., J.W. Stone, A. Gole, C.J. Murphy, and T.L. Sabo-Attwood. 2008. Nano Letters 8 (1): 302–306.

    Article  CAS  Google Scholar 

  15. Sau, T.K., and C.J. Murphy. 2004. Journal of the American Chemical Society 126 (28): 8648–8649.

    Article  CAS  Google Scholar 

  16. Gou, L., and C.J. Murphy. 2005. Chemistry of Materials 17 (14): 3668–3672.

    Article  CAS  Google Scholar 

  17. Liu, M., and P. Guyot-Sionnest. 2005. The Journal of Physical Chemistry B 109 (47): 22192–22200.

    Article  CAS  Google Scholar 

  18. Lohse, S.E., and C.J. Murphy. 2013. Chemistry of Materials 25 (8): 1250–1261.

    Article  CAS  Google Scholar 

  19. Canonico-May, S.A., K.R. Beavers, M.J. Melvin, A.M. Alkilany, C.L. Duvall, and J.W. Stone. 2016. Journal of Colloid and Interface Science 463: 229–232.

    Article  CAS  Google Scholar 

  20. Khlebtsov, B.N., V.A. Khanadeev, J. Ye, G.B. Sukhorukov, and N.G. Khlebtsov. 2014. Langmuir 30 (6): 1696–1703.

    Article  CAS  Google Scholar 

  21. Kozek, K.A., K.M. Kozek, W.-C. Wu, S.R. Mishra, and J.B. Tracy. 2013. Chemistry of Materials 25 (22): 4537–4544.

    Article  CAS  Google Scholar 

  22. Scarabelli, L., M. Grzelczak, and L.M. Liz-Marzán. 2013. Chemistry of Materials 25 (21): 4232–4238.

    Article  CAS  Google Scholar 

  23. Rodríguez-Fernández, J., J. Perez-Juste, P. Mulvaney, and L.M. Liz-Marzan. 2005. The Journal of Physical Chemistry B 109 (30): 14257–14261.

    Article  Google Scholar 

  24. Ye, X., C. Zheng, J. Chen, Y. Gao, and C.B. Murray. 2013. Nano Letters 13 (2): 765–771.

    Article  CAS  Google Scholar 

  25. Rana, S., Y.-C. Yeh, and V.M. Rotello. 2010. Current Opinion in Chemical Biology 14 (6): 828–834.

    Article  CAS  Google Scholar 

  26. Huang, X., P.K. Jain, I. El-Sayed, and M.A. El-Sayed. 2007. Nanomedicine(Lond) 2 (5): 681–693.

    Google Scholar 

  27. Pissuwan, D., S.M. Valenzuela, and M.B. Cortie. 2006. Trends in Biotechnology 24 (2): 62–67.

    Article  CAS  Google Scholar 

  28. Pérez-Juste, J., I. Pastoriza-Santos, L.M. Liz-Marzán, and P. Mulvaney. 2005. Coordination Chemistry Reviews 249 (17): 1870–1901.

    Article  Google Scholar 

  29. Skrabalak, S.E., J. Chen, Y. Sun, X. Lu, L. Au, C.M. Cobley, and Y. Xia. 2008. Accounts of Chemical Research 41 (12): 1587–1595.

    Article  CAS  Google Scholar 

  30. Loo, C., A. Lin, L. Hirsch, M.-H. Lee, J. Barton, N. Halas, J. West, and R. Drezek. 2004. Technology in Cancer Research & Treatment 3 (1): 33–40.

    Article  CAS  Google Scholar 

  31. Hu, M., J. Chen, Z.-Y. Li, L. Au, G.V. Hartland, X. Li, M. Marquez, and Y. Xia. 2006. Chemical Society Reviews 35 (11): 1084–1094.

    Article  CAS  Google Scholar 

  32. Krumpfer, J.W., T. Schuster, M. Klapper, and K. Müllen. 2013. Nano Today 8 (4): 417–438.

    Article  CAS  Google Scholar 

  33. Sperling, R.A., Parak, W. 2010. Philosophical Transactions of the Royal Society, A. 368(1915): 1333–1383.

    Google Scholar 

  34. Gao, J., X. Huang, H. Liu, F. Zan, and J. Ren. 2012. Langmuir 28 (9): 4464–4471.

    Article  CAS  Google Scholar 

  35. Häkkinen, H. 2012. Nature Chemistry 4 (6): 443–455.

    Article  Google Scholar 

  36. Jin, R. 2010. Nanoscale 2 (3): 343–362.

    Article  CAS  Google Scholar 

  37. Manson, J., D. Kumar, B.J. Meenan, and D. Dixon. 2011. Gold Bulletin 44 (2): 99–105.

    Article  CAS  Google Scholar 

  38. Lipka, J., M. Semmler-Behnke, R.A. Sperling, A. Wenk, S. Takenaka, C. Schleh, T. Kissel, W.J. Parak, and W.G. Kreyling. 2010. Biomaterials 31 (25): 6574–6581.

    Article  CAS  Google Scholar 

  39. Giljohann, D.A., D.S. Seferos, W.L. Daniel, M.D. Massich, P.C. Patel, and C.A. Mirkin. 2010. Angewandte Chemie International Edition 49 (19): 3280–3294.

    Article  CAS  Google Scholar 

  40. DeLong, R.K., C.M. Reynolds, Y. Malcolm, A. Schaeffer, T. Severs, and A. Wanekaya. 2010. Nanotechnology, Science and Applications 3 (1): 53–63.

    Article  CAS  Google Scholar 

  41. De Villiers, M.M., D.P. Otto, S.J. Strydom, and Y.M. Lvov. 2011. Advanced Drug Delivery Reviews 63 (9): 701–715.

    Article  Google Scholar 

  42. Kim, K., S.-W. Huang, S. Ashkenazi, M. O’Donnell, A. Agarwal, N.A. Kotov, M.F. Denny, and M.J. Kaplan. 2007. Applied Physics Letters 90 (22): 223901.

    Article  Google Scholar 

  43. Kirui, D.K., S. Krishnan, A.D. Strickland, and C.A. Batt. 2011. Macromolecular Bioscience 11 (6): 779–788.

    Article  CAS  Google Scholar 

  44. Alkilany, A.M., L.B. Thompson, and C.J. Murphy. 2010. ACS Applied Materials & Interfaces 2 (12): 3417–3421.

    Google Scholar 

  45. Oishi, M., J. Nakaogami, T. Ishii, and Y. Nagasaki. 2006. Chemistry Letters 35 (9): 1046–1047.

    Article  CAS  Google Scholar 

  46. Ghosh, P., G. Han, M. De, C.K. Kim, and V.M. Rotello. 2008. Advanced Drug Delivery Reviews 60 (11): 1307–1315.

    Article  CAS  Google Scholar 

  47. Rosi, N.L., D.A. Giljohann, C.S. Thaxton, A.K. Lytton-Jean, M.S. Han, and C.A. Mirkin. 2006. Science 312 (5776): 1027–1030.

    Article  CAS  Google Scholar 

  48. Nam, J.-M., C.S. Thaxton, and C.A. Mirkin. 2003. Science 301 (5641): 1884–1886.

    Article  CAS  Google Scholar 

  49. Medley, C.D., J.E. Smith, Z. Tang, Y. Wu, S. Bamrungsap, and W. Tan. 2008. Analytical Chemistry 80 (4): 1067–1072.

    Article  CAS  Google Scholar 

  50. Lee, J.S., M.S. Han, and C.A. Mirkin. 2007. Angewandte Chemie International Edition 46 (22): 4093–4096.

    Article  CAS  Google Scholar 

  51. Lee, J.-S., P.A. Ulmann, M.S. Han, and C.A. Mirkin. 2008. Nano Letters 8 (2): 529–533.

    Article  CAS  Google Scholar 

  52. Thaxton, C.S., D.G. Georganopoulou, and C.A. Mirkin. 2006. Clinica Chimica Acta 363 (1): 120–126.

    Article  CAS  Google Scholar 

  53. Park, S.Y., A.K. Lytton-Jean, B. Lee, S. Weigand, G.C. Schatz, and C.A. Mirkin. 2008. Nature 451 (7178): 553–556.

    Article  CAS  Google Scholar 

  54. Dreaden, E.C., M.A. Mackey, X. Huang, B. Kang, and M.A. El-Sayed. 2011. Chemical Society Reviews 40 (7): 3391–3404.

    Article  CAS  Google Scholar 

  55. Bazak, R., M. Houri, S. El Achy, S. Kamel, and T. Refaat. 2015. Journal of Cancer Research and Clinical Oncology 141 (5): 769–784.

    Google Scholar 

  56. Llevot, A., and D. Astruc. 2012. Chemical Society Reviews 41 (1): 242–257.

    Article  CAS  Google Scholar 

  57. Cho, K., X. Wang, S. Nie, and D.M. Shin. 2008. Clinical Cancer Research 14 (5): 1310–1316.

    Article  CAS  Google Scholar 

  58. Byrne, J.D., T. Betancourt, and L. Brannon-Peppas. 2008. Advanced Drug Delivery Reviews 60 (15): 1615–1626.

    Article  CAS  Google Scholar 

  59. Zhang, F., E. Lees, F. Amin, P. Rivera_Gil, F. Yang, P. Mulvaney, and W.J. Parak. 2011. Small 7 (22): 3113–3127.

    Google Scholar 

  60. Sperling, R.A., P.R. Gil, F. Zhang, M. Zanella, and W.J. Parak. 2008. Chemical Society Reviews 37 (9): 1896–1908.

    Article  CAS  Google Scholar 

  61. Sokolov, K., M. Follen, J. Aaron, I. Pavlova, A. Malpica, R. Lotan, and R. Richards-Kortum. 2003. Cancer Research 63 (9): 1999–2004.

    CAS  Google Scholar 

  62. Rayavarapu, R.G., W. Petersen, C. Ungureanu, J.N. Post, T.G. van Leeuwen, and S.J. Manohar. 2007. Biomedical Imaging 2007 (1): 5–5.

    Google Scholar 

  63. Amendola, V., and M. Meneghetti. 2007. Journal of Materials Chemistry 17 (44): 4705–4710.

    Article  CAS  Google Scholar 

  64. Kumar, A., H. Ma, X. Zhang, K. Huang, S. Jin, J. Liu, T. Wei, W. Cao, G. Zou, and X.-J. Liang. 2012. Biomaterials 33 (4): 1180–1189.

    Article  CAS  Google Scholar 

  65. Nguyen, C.T., J.T. Nguyen, S. Rutledge, J. Zhang, C. Wang, and G.C. Walker. 2010. Cancer Letters 292 (1): 91–97.

    Article  CAS  Google Scholar 

  66. Bickford, L.R., J. Chang, K. Fu, J. Sun, Y. Hu, A. Gobin, T.-K. Yu, and R.A. Drezek. 2008. NanoBiotechnology 4 (1–4): 1–8.

    Article  CAS  Google Scholar 

  67. Zhang, Y., and J. Zhang. 2005. Journal of Colloid and Interface Science 283 (2): 352–357.

    Article  CAS  Google Scholar 

  68. Popovtzer, R., A. Agrawal, N.A. Kotov, A. Popovtzer, J. Balter, T.E. Carey, and R. Kopelman. 2008. Nano Letters 8 (12): 4593–4596.

    Article  CAS  Google Scholar 

  69. Tong, L., Q. Wei, A. Wei, and J.X. Cheng. 2009. Photochemistry and Photobiology 85 (1): 21–32.

    Article  CAS  Google Scholar 

  70. Reuveni, T., M. Motiei, Z. Romman, A. Popovtzer, and R. Popovtzer. 2011. International Journal of Nanomedicine 6 (2859): e64.

    Google Scholar 

  71. Qian, X., X.-H. Peng, D.O. Ansari, Q. Yin-Goen, G.Z. Chen, D.M. Shin, L. Yang, A.N. Young, M.D. Wang, and S. Nie. 2008. Nature Biotechnology 26 (1): 83–90.

    Article  CAS  Google Scholar 

  72. Huang, X., I.H. El-Sayed, W. Qian, and M.A. El-Sayed. 2006. Journal of the American Chemical Society 128 (6): 2115–2120.

    Article  CAS  Google Scholar 

  73. El-Sayed, I.H., X. Huang, and M.A. El-Sayed. 2006. Cancer Letters 239 (1): 129–135.

    Article  CAS  Google Scholar 

  74. Chen, J., D. Wang, J. Xi, L. Au, A. Siekkinen, A. Warsen, Z.-Y. Li, H. Zhang, Y. Xia, and X. Li. 2007. Nano Letters 7 (5): 1318–1322.

    Article  CAS  Google Scholar 

  75. Cobley, C.M., L. Au, J. Chen, and Y. Xia. 2010. Expert Opinion on Drug Delivery 7 (5): 577–587.

    Google Scholar 

  76. Melancon, M.P., W. Lu, Z. Yang, R. Zhang, Z. Cheng, A.M. Elliot, J. Stafford, T. Olson, J.Z. Zhang, and C. Li. 2008. Molecular Cancer Therapeutics 7 (6): 1730–1739.

    Article  CAS  Google Scholar 

  77. Loo, C., A. Lowery, N. Halas, J. West, and R. Drezek. 2005. Nano Letters 5 (4): 709–711.

    Article  CAS  Google Scholar 

  78. Lévy, R. 2006. ChemBioChem 7 (8): 1141–1145.

    Article  Google Scholar 

  79. Lévy, R., N.T. Thanh, R.C. Doty, I. Hussain, R.J. Nichols, D.J. Schiffrin, M. Brust, and D.G. Fernig. 2004. Journal of the American Chemical Society 126 (32): 10076–10084.

    Article  Google Scholar 

  80. Slocik, J.M., M.O. Stone, and R.R. Naik. 2005. Small 1 (11): 1048–1052.

    Article  CAS  Google Scholar 

  81. Tkachenko, A.G., H. Xie, D. Coleman, W. Glomm, J. Ryan, M.F. Anderson, S. Franzen, and D.L. Feldheim. 2003. Journal of the American Chemical Society 125 (16): 4700–4701.

    Article  CAS  Google Scholar 

  82. Slocik, J.M., J.S. Zabinski, D.M. Phillips, and R.R. Naik. 2008. Small 4 (5): 548–551.

    Article  CAS  Google Scholar 

  83. Wust, P., B. Hildebrandt, G. Sreenivasa, B. Rau, J. Gellermann, H. Riess, R. Felix, and P. Schlag. 2002. The Lancet Oncology 3 (8): 487–497.

    Google Scholar 

  84. Chua, T.C., G. Robertson, W. Liauw, R. Farrell, T.D. Yan, and D.L.J. Morris. 2009. Journal of Cancer Research and Clinical Oncology 135 (12): 1637–1645.

    Article  Google Scholar 

  85. Chicheł, A., J. Skowronek, M. Kubaszewska, and M. Kanikowski. 2007. Reports of Practical Oncology and Radiotherapy 12 (5): 267–275.

    Article  Google Scholar 

  86. Stauffer, P.R. 2005. International Journal of Hyperthermia 21 (8): 731–744.

    Article  Google Scholar 

  87. I.P Soares, P., I. MM Ferreira, R. AGBN Igreja, C. MM Novo, and J. PMR Borges. 2012. Recent Patents on Anti-Cancer Drug Discovery 7 (1): 64–73.

    Google Scholar 

  88. Camerin, M., S. Rello, A. Villanueva, X. Ping, M.E. Kenney, M.A. Rodgers, and G. Jori. 2005. European Journal of Cancer 41 (8): 1203–1212.

    Article  CAS  Google Scholar 

  89. Huang, X., P.K. Jain, I.H. El-Sayed, and M.A. El-Sayed. 2008. Lasers in Medical Science 23 (3): 217–228.

    Article  Google Scholar 

  90. Wang, J. 2005. Electroanalysis 17 (1): 7–14.

    Article  CAS  Google Scholar 

  91. Michalet, X., F. Pinaud, L. Bentolila, J. Tsay, S. Doose, J. Li, G. Sundaresan, A. Wu, S. Gambhir, and S. Weiss. 2005. Science 307 (5709): 538–544.

    Article  CAS  Google Scholar 

  92. Eustis, S., and M.A. El-Sayed. 2006. Chemical Society Reviews 35 (3): 209–217.

    Article  CAS  Google Scholar 

  93. Huang, X., and M.A. El-Sayed. 2010. Journal of Advanced Research 1 (1): 13–28.

    Article  Google Scholar 

  94. Jain, P.K., X. Huang, I.H. El-Sayed, and M.A. El-Sayed. 2008. Accounts of Chemical Research 41 (12): 1578–1586.

    Article  CAS  Google Scholar 

  95. Njoki, P.N., I.-I.S. Lim, D. Mott, H.-Y. Park, B. Khan, S. Mishra, R. Sujakumar, J. Luo, and C.-J. Zhong. 2007. The Journal of Physical Chemistry C 111 (40): 14664–14669.

    Google Scholar 

  96. Huang, X., S. Neretina, and M.A. El-Sayed. 2009. Advanced Materials 21 (48): 4880–4910.

    Article  CAS  Google Scholar 

  97. Au, L., J. Chen, L.V. Wang, and Y. Xia. 2010. Methods in Molecular Biology, 83–99.

    Google Scholar 

  98. Dykman, L., and N. Khlebtsov. 2012. Chemical Society Reviews 41 (6): 2256–2282.

    Article  CAS  Google Scholar 

  99. Kennedy, L.C., L.R. Bickford, N.A. Lewinski, A.J. Coughlin, Y. Hu, E.S. Day, J.L. West, and R.A. Drezek. 2011. Small 7 (2): 169–183.

    Article  CAS  Google Scholar 

  100. Perrault, S.D., C. Walkey, T. Jennings, H.C. Fischer, and W.C. Chan. 2009. Nano Letters 9 (5): 1909–1915.

    Article  CAS  Google Scholar 

  101. Pissuwan, D., T. Niidome, and M.B. Cortie. 2011. Journal of Controlled Release 149 (1): 65–71.

    Article  CAS  Google Scholar 

  102. van der Meel, R., L.J. Vehmeijer, R.J. Kok, G. Storm, and E.V. van Gaal. 2013. Advanced Drug Delivery Reviews 65 (10): 1284–1298.

    Article  Google Scholar 

  103. Dickerson, E.B., E.C. Dreaden, X. Huang, I.H. El-Sayed, H. Chu, S. Pushpanketh, J.F. McDonald, and M.A. El-Sayed. 2008. Cancer Letters 269 (1): 57–66.

    Article  CAS  Google Scholar 

  104. Wang, S., W. Xi, F. Cai, X. Zhao, Z. Xu, J. Qian, and S. He. 2015. Theranostics 5 (3): 251.

    Article  CAS  Google Scholar 

  105. Wu, H.-L., C.-H. Kuo, and M.H. Huang. 2010. Langmuir 26 (14): 12307–12313.

    Article  CAS  Google Scholar 

  106. Barbosa, S., A. Agrawal, L. Rodríguez-Lorenzo, I. Pastoriza-Santos, R.A. Alvarez-Puebla, A. Kornowski, H. Weller, and L.M. Liz-Marzán. 2010. Langmuir 26 (18): 14943–14950.

    Article  CAS  Google Scholar 

  107. Schwartzberg, A.M., T.Y. Olson, C.E. Talley, and J.Z. Zhang. 2006. The Journal of Physical Chemistry B 110 (40): 19935–19944.

    Article  CAS  Google Scholar 

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Stone, J.W., Alkilany, A.M., Hamaly, M.A., Canonico-May, S. (2017). Biomedical Applications of Anisotropic Gold Nanoparticles. In: Hunyadi Murph, S., Larsen, G., Coopersmith, K. (eds) Anisotropic and Shape-Selective Nanomaterials. Nanostructure Science and Technology. Springer, Cham. https://doi.org/10.1007/978-3-319-59662-4_13

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