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Transcatheter Therapy for Mitral Regurgitation: A Review of the Literature

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Percutaneous Treatment of Left Side Cardiac Valves

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Abstract

Growing evidence in the literature testifies to the clinical safety and efficacy of the percutaneous treatment of mitral regurgitation (MR). The available data are mainly from multicenter registries or from case studies collected prospectively in individual centers. Data from randomized trials is rather limited. Among the different techniques available for interventional treatment of the mitral valve, percutaneous repair with the MitraClip System (Abbott Vascular, Santa Clara, CA) has definitely been the most studied technique, and the one with the most data currently available, though the feasibility and safety data for other percutaneous techniques (Cardioband, Mitralign, Carillon, transcatheter implantable mitral valve) have recently been published.

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References

  1. Wan B, Rahnavardi M, Tian DH, Phan K, Munkholm-Larsen S, Bannon PG, Yan TD. A meta-analysis of MitraClip system versus surgery for treatment of severe mitral regurgitation. Ann Cardiothorac Surg. 2013;2(6):683–92. doi:10.3978/j.issn.2225-319X.2013.11.02.

    PubMed  PubMed Central  Google Scholar 

  2. D’ascenzo F, Moretti C, Marra WG, Montefusco A, Omede P, Taha S, Castagno D, Gaemperli O, Taramasso M, Frea S, Pidello S, Rudolph V, Franzen O, Braun D, Giannini C, Ince H, Perl L, Zoccai G, Marra S, D'Amico M, Maisano F, Rinaldi M, Gaita F. Meta-analysis of the usefulness of Mitraclip in patients with functional mitral regurgitation. Am J Cardiol. 2015;116(2):325–31. doi:10.1016/j.amjcard.2015.04.025.

    Article  PubMed  Google Scholar 

  3. Feldman T, Foster E, Glower DD, Kar S, Rinaldi MJ, Fail PS, Smalling RW, Siegel R, Rose GA, Engeron E, Loghin C, Trento A, Skipper ER, Fudge T, Letsou GV, Massaro JM, Mauri L, EVEREST II Investigators. Percutaneous repair or surgery for mitral regurgitation. N Engl J Med. 2011;364(15):1395–406. doi:10.1056/NEJMoa1009355.

    Article  CAS  PubMed  Google Scholar 

  4. Maisano F, Taramasso M, Nickenig G, Hammerstingl C, Vahanian A, Messika-Zeitoun D, Baldus S, Huntgeburth M, Alfieri O, Colombo A, La Canna G, Agricola E, Zuber M, Tanner FC, Topilsky Y, Kreidel F, Kuck KH. Cardioband, a transcatheter surgical-like direct mitral valve annuloplasty system: early results of the feasibility trial. Eur Heart J. 2016;37(10):817–25. doi:10.1093/eurheartj/ehv603.

    Article  PubMed  Google Scholar 

  5. Nickenig G, Schueler R, Dager A, Martinez Clark P, Abizaid A, Siminiak T, Buszman P, Demkow M, Ebner A, Asch FM, Hammerstingl C. Treatment of chronic functional mitral valve regurgitation with a percutaneous annuloplasty system. J Am Coll Cardiol. 2016;67(25):2927–36. doi:10.1016/j.jacc.2016.03.591.

    Article  PubMed  Google Scholar 

  6. Feldman T, Wasserman HS, Herrmann HC, Block P, Gray W, Hamilton A, Zunamon A, Homma S, Di Tullio MR, Kraybill K, Merlino J, Martin R, Rodriguez L, Stewart WJ, Whitlow P, Wiegers SE, Silvestry FE, Foster E, Feldman T. Percutaneous mitral valve repair using the edge-to-edge technique six-month results of the EVEREST phase I clinical trial. J Am Coll Cardiol. 2006;46:2134–40.

    Article  Google Scholar 

  7. Feldman T, Kar S, Rinaldi M, Fail P, Hermiller J, Smalling R, Whitlow PL, Gray W, Low R, Herrmann HC, Lim S, Foster E, Glower D, EVEREST Investigators. Percutaneous mitral repair with the MitraClip system: safety and midterm durability in the initial EVEREST (endovascular valve edge-to-edge REpair study) cohort. J Am Coll Cardiol. 2009;54:686–94.

    Article  PubMed  Google Scholar 

  8. Feldman T, Kar S, Elmariah S, Smart SC, Trento A, Siegel RJ, Apruzzese P, Fail P, Rinaldi MJ, Smalling RW, Hermiller JB, Heimansohn D, Gray WA, Grayburn PA, Mack MJ, Lim DS, Ailawadi G, Herrmann HC, Acker MA, Silvestry FE, Foster E, Wang A, Glower DD, Mauri L, EVEREST II Investigators. Randomized comparison of percutaneous repair and surgery for mitral regurgitation: 5-year results of EVEREST II. J Am Coll Cardiol. 2015;66(25):2844–54. doi:10.1016/j.jacc.2015.10.018.+.

    Article  PubMed  Google Scholar 

  9. Glower DD, Kar S, Trento A, Lim DS, Bajwa T, Quesada R, Whitlow PL, Rinaldi MJ, Grayburn P, Mack MJ, Mauri L, McCarthy PM, Feldman T. Percutaneous mitral valve repair for mitral regurgitation in high-risk patients: results of the EVEREST II study. J Am Coll Cardiol. 2014;64(2):172–81. doi:10.1016/j.jacc.2013.12.062.

    Article  PubMed  Google Scholar 

  10. Maisano F, Franzen O, Baldus S, Schäfer U, Hausleiter J, Butter C, Ussia GP, Sievert H, Richardt G, Widder JD, Moccetti T, Schillinger W. Percutaneous mitral valve interventions in the real world: early and 1-year results from the ACCESS-EU, a prospective, multicenter, nonrandomized post-approval study of the MitraClip therapy in Europe. J Am Coll Cardiol. 2013;62(12):1052–61. doi:10.1016/j.jacc.2013.02.094.

    Article  PubMed  Google Scholar 

  11. Nickenig G, Estevez-Loureiro R, Franzen O, Tamburino C, Vanderheyden M, Lüscher TF, Moat N, Price S, Dall’Ara G, Winter R, Corti R, Grasso C, Snow TM, Jeger R, Blankenberg S, Settergren M, Tiroch K, Balzer J, Petronio AS, Büttner HJ, Ettori F, Sievert H, Fiorino MG, Claeys M, Ussia GP, Baumgartner H, Scandura S, Alamgir F, Keshavarzi F, Colombo A, Maisano F, Ebelt H, Aruta P, Lubos E, Plicht B, Schueler R, Pighi M, Di Mario C, Transcatheter Valve Treatment Sentinel Registry Investigators of the EURObservational Research Programme of the European Society of Cardiology. Percutaneous mitral valve edge-to-edge repair: in-hospital results and 1-year follow-up of 628 patients of the 2011-2012 pilot European sentinel registry. J Am Coll Cardiol. 2014;64(9):875–84. doi:10.1016/j.jacc.2014.06.1166.

    Article  PubMed  Google Scholar 

  12. Puls M, Lubos E, Boekstegers P, von Bardeleben RS, Ouarrak T, Butter C, Zuern CS, Bekeredjian R, Sievert H, Nickenig G, Eggebrecht H, Senges J, Schillinger W. One-year outcomes and predictors of mortality after MitraClip therapy in contemporary clinical practice: results from the German transcatheter mitral valve interventions registry. Eur Heart J. 2016;37(8):703–12. doi:10.1093/eurheartj/ehv627.

    Article  PubMed  Google Scholar 

  13. Capodanno D, Adamo M, Barbanti M, Giannini C, Laudisa ML, Cannata S, Curello S, Immè S, Maffeo D, Bedogni F, Petronio AS, Ettori F, Tamburino C, Grasso C, GRASP-IT Investigators. Predictors of clinical outcomes after edge-to-edge percutaneous mitral valve repair. Am Heart J. 2015;170(1):187–95. doi:10.1016/j.ahj.2015.04.010.

    Article  PubMed  Google Scholar 

  14. Sorajja P, Mack M, Vemulapalli S, Holmes DR Jr, Stebbins A, Kar S, Lim DS, Thourani V, McCarthy P, Kapadia S, Grayburn P, Pedersen WA, Ailawadi G. Initial experience with commercial transcatheter mitral valve repair in the United States. J Am Coll Cardiol. 2016;67(10):1129–40. doi:10.1016/j.jacc.2015.12.054.

    Article  PubMed  Google Scholar 

  15. Sürder D, Pedrazzini G, Gaemperli O, Biaggi P, Felix C, Rufibach K, der Maur CA, Jeger R, Buser P, Kaufmann BA, Moccetti M, Hürlimann D, Bühler I, Bettex D, Scherman J, Pasotti E, Faletra FF, Zuber M, Moccetti T, Lüscher TF, Erne P, Grünenfelder J, Corti R. Predictors for efficacy of percutaneous mitral valve repair using the MitraClip system: the results of the MitraSwiss registry. Heart. 2013;99(14):1034–40. doi:10.1136/heartjnl-2012-303105.

    Article  PubMed  Google Scholar 

  16. Yeo KK, Yap J, Yamen E, Muda N, Tay E, Walters DL, Santoso T, Liu X, Jansz P, Yip J, Zambahari R, Passage J, Koh TH, Wang J, Scalia G, Kuntjoro I, Soesanto AM, Muller D. Percutaneous mitral valve repair with the MitraClip: early results from the MitraClip Asia-Pacific registry (MARS). EuroIntervention. 2014;10(5):620–5. doi:10.4244/EIJV10I5A107.

    Article  PubMed  Google Scholar 

  17. Vakil K, Roukoz H, Sarraf M, Krishnan B, Reisman M, Levy WC, Adabag S. Safety and efficacy of the MitraClip® system for severe mitral regurgitation: a systematic review. Catheter Cardiovasc Interv. 2014;84(1):129–36. doi:10.1002/ccd.25347.

    Article  PubMed  Google Scholar 

  18. Wan B, Rahnavardi M, Tian DH, Phan K, Munkholm-Larsen S, Bannon PG, Yan TD. A meta-analysis of MitraClip system versus surgery for treatment of severe mitral regurgitation. Ann Cardiothorac Surg. 2013;2(6):683–92. doi:10.3978/j.issn.2225-319X.2013.11.02.

    PubMed  PubMed Central  Google Scholar 

  19. D’ascenzo F, Moretti C, Marra WG, Montefusco A, Omede P, Taha S, Castagno D, Gaemperli O, Taramasso M, Frea S, Pidello S, Rudolph V, Franzen O, Braun D, Giannini C, Ince H, Perl L, Zoccai G, Marra S, D’Amico M, Maisano F, Rinaldi M, Gaita F. Meta-analysis of the usefulness of Mitraclip in patients with functional mitral regurgitation. Am J Cardiol. 2015;116(2):325–31. doi:10.1016/j.amjcard.2015.04.025.

    Article  PubMed  Google Scholar 

  20. Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP III, Guyton RA, O'Gara PT, Ruiz CE, Skubas NJ, Sorajja P, Sundt TM III, Thomas JD, American College of Cardiology/American Heart Association Task Force on Practice Guidelines. 2014 AHA/ACC guideline for the management of patients with valvular heart disease: executive summary: a report of the American College of Cardiology/American Heart Association task force on practice guidelines. J Am Coll Cardiol. 2014;63(22):2438–88. doi:10.1016/j.jacc.2014.02.537.

    Article  PubMed  Google Scholar 

  21. Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JG, Coats AJ, Falk V, González-Juanatey JR, Harjola VP, Jankowska EA, Jessup M, Linde C, Nihoyannopoulos P, Parissis JT, Pieske B, Riley JP, Rosano GM, Ruilope LM, Ruschitzka F, Rutten FH, van der Meer P, Authors/Task Force Members; Document Reviewers. 2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: the task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the heart failure association (HFA) of the ESC. Eur J Heart Fail. 2016;18(8):891–975. doi:10.1002/ejhf.592. [Epub ahead of print]

    Article  PubMed  Google Scholar 

  22. Stone GW, Vahanian AS, Adams DH, Abraham WT, Borer JS, Bax JJ, Schofer J, Cutlip DE, Krucoff MW, Blackstone EH, Généreux P, Mack MJ, Siegel RJ, Grayburn PA, Enriquez-Sarano M, Lancellotti P, Filippatos G, Kappetein AP, Mitral Valve Academic Research Consortium (MVARC). Clinical trial design principles and endpoint definitions for transcatheter mitral valve repair and replacement: part 1: clinical trial design principles: a consensus document from the mitral valve academic research consortium. J Am Coll Cardiol. 2015;66(3):278–307. doi:10.1016/j.jacc.2015.05.046.

    Article  PubMed  Google Scholar 

  23. Stone GW, Adams DH, Abraham WT, Kappetein AP, Généreux P, Vranckx P, Mehran R, Kuck KH, Leon MB, Piazza N, Head SJ, Filippatos G, Vahanian AS, Mitral Valve Academic Research Consortium (MVARC). Clinical trial design principles and endpoint definitions for transcatheter mitral valve repair and replacement: part 2: endpoint definitions: a consensus document from the mitral valve academic research consortium. J Am Coll Cardiol. 2015;66(3):308–21. doi:10.1016/j.jacc.2015.05.049.

    Article  PubMed  Google Scholar 

  24. Schofer J, Siminiak T, Haude M, Herrman JP, Vainer J, Wu JC, Levy WC, Mauri L, Feldman T, Kwong RY, Kaye DM, Duffy SJ, Tübler T, Degen H, Brandt MC, Van Bibber R, Goldberg S, Reuter DG, Hoppe UC. Percutaneous mitral annuloplasty for functional mitral regurgitation: results of the CARILLON mitral Annuloplasty device European Union study. Circulation. 2009;120(4):326–33. doi:10.1161/CIRCULATIONAHA. 109.849885.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Siminiak T, Wu JC, Haude M, Hoppe UC, Sadowski J, Lipiecki J, Fajadet J, Shah AM, Feldman T, Kaye DM, Goldberg SL, Levy WC, Solomon SD, Reuter DG. Treatment of functional mitral regurgitation by percutaneous annuloplasty: results of the TITAN trial. Eur J Heart Fail. 2012;14(8):931–8. doi:10.1093/eurjhf/hfs076.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Lipiecki J, Siminiak T, Sievert H, Müller-Ehmsen J, Degen H, Wu JC, Schandrin C, Kalmucki P, Hofmann I, Reuter D, Goldberg SL, Haude M; for the TITAN II Investigators. Coronary sinus-based percutaneous annuloplasty as treatment for functional mitral regurgitation: the TITAN II trial. Open Heart. 2016;3. doi:10.1136/openhrt-2016-000411.

  27. Cheung A, Webb J, Verheye S, Moss R, Boone R, Leipsic J, Ree R, Banai S. Short-term results of transapical transcatheter mitral valve implantation for mitral regurgitation. J Am Coll Cardiol. 2014;64(17):1814–9. doi:10.1016/j.jacc.2014. 06.1208.

    Article  PubMed  Google Scholar 

  28. Søndergaard L, De Backer O, Franzen OW, Holme SJ, Ihlemann N, Vejlstrup NG, Hansen PB, Quadri A. First-in-human case of transfemoral CardiAQ mitral valve implantation. Circ Cardiovasc Interv. 2015;8(7):e002135. doi:10.1161/CIRC INTERVENTIONS.115.002135.

    Article  PubMed  Google Scholar 

  29. Perpetua EM, Reisman M. The Tendyne transcatheter mitral valve implantation system. EuroIntervention. 2015;11 Suppl W:W78–9. doi:10.4244/EIJV11SWA23.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Ferrarotto Hospital, University of Catania, Via Citelli 6, 95124, Catania, Italy

    Sergio Buccheri

  2. Department of General Surgery and Medical-Surgical Specialties, University of Catania, Catania, Italy

    Davide Capodanno

  3. Ferrarotto Hospital, University of Catania, Via Citelli 6, 95124, Catania, Italy

    Davide Capodanno

Authors
  1. Sergio Buccheri
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  2. Davide Capodanno
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Correspondence to Davide Capodanno .

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Editors and Affiliations

  1. Ferrarotto Hospital, University of Catania, Catania, Italy

    Corrado Tamburino

  2. Ferrarotto Hospital, University of Catania, Catania, Italy

    Marco Barbanti

  3. Ferrarotto Hospital, University of Catania, Catania, Italy

    Davide Capodanno

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Buccheri, S., Capodanno, D. (2018). Transcatheter Therapy for Mitral Regurgitation: A Review of the Literature. In: Tamburino, C., Barbanti, M., Capodanno, D. (eds) Percutaneous Treatment of Left Side Cardiac Valves. Springer, Cham. https://doi.org/10.1007/978-3-319-59620-4_12

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  • DOI: https://doi.org/10.1007/978-3-319-59620-4_12

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