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The Biomechanical Rupture Risk Assessment of Abdominal Aortic Aneurysms—Method and Clinical Relevance

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Biomedical Technology

Part of the book series: Lecture Notes in Applied and Computational Mechanics ((LNACM,volume 84))

Abstract

An Abdominal Aortic Aneurysm (AAA) is an enlargement of the infrarenal aorta, a serious condition whose clinical treatment requires assessing its risk of rupture. This chapter reviews the current state of the Biomechanical Rupture Risk Assessment (BRRA), a non-invasive diagnostic method to calculate such AAA rupture risk, and emphasizes on constitutive modeling of AAA tissues. Histology and mechanical properties of the normal and aneurysmatic walls are summarized and related to proposed constitutive descriptions. Models for the passive vessel wall as well as their adaptation in time are discussed. Reported clinical BRRA validation studies are summarized and their clinical relevance is discussed. Despite open problems in AAA biomechanics, like robust modeling vascular tissue adaptation to mechanical and biochemical environments, a significant body of current validation evidence suggests integrating the BRRA method into the clinical decision-making process.

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  1. KTH Royal Institute of Technology, Stockholm, Sweden

    T. Christian Gasser

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  1. T. Christian Gasser
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  1. Institute of Continuum Mechanics, Leibniz Universität Hannover, Hannover, Germany

    Peter Wriggers

  2. Hals-Nasen-Ohrenklinik, Medical School Hannover, Hannover, Germany

    Thomas Lenarz

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Gasser, T.C. (2018). The Biomechanical Rupture Risk Assessment of Abdominal Aortic Aneurysms—Method and Clinical Relevance. In: Wriggers, P., Lenarz, T. (eds) Biomedical Technology. Lecture Notes in Applied and Computational Mechanics, vol 84. Springer, Cham. https://doi.org/10.1007/978-3-319-59548-1_13

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