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Dermal Drug Selection and Development pp 49–67Cite as

Assessing Drug Concentration in Skin: Direct and Indirect Methods

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Abstract

This chapter reviews the most commonly used topical pharmacokinetic techniques. Numerous other techniques (e.g., the non-invasive spectroscopic techniques like confocal, fluorescence techniques as well as the NMR technique) are not described here as they will have one or more of the following characteristics: very specific for a drug or disease, possibly impractical, possibly not quantitative, possibly lacking sensitivity or possibly at a too early stage of development. They cannot, therefore, be applicable as versatile techniques for studying topical pharmacokinetics.

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Authors and Affiliations

  1. Oncodesign, Centre de Recherches François Hyafil, Villebon sur Yvette, France

    Lionel Trottet

  2. Dermatology Department, Medical School, University of California, San Francisco, CA, USA

    Howard Maibach MD

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  1. Lionel Trottet
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  2. Howard Maibach MD
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Correspondence to Lionel Trottet .

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Trottet, L., Maibach, H. (2017). Assessing Drug Concentration in Skin: Direct and Indirect Methods. In: Dermal Drug Selection and Development. Springer, Cham. https://doi.org/10.1007/978-3-319-59504-7_5

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