The Disease

  • Marta Díaz-MenéndezEmail author
  • Clara Crespillo-Andújar
Part of the SpringerBriefs in Immunology book series (BRIEFSIMMUN)


Approximately 20% of ZIKV infected patients show symptoms, mainly low grade fever, maculopapular rash, arthralgia (particularly in the small joints of hand and feet associated with peri-articular edema) or conjunctivitis, although multiple clinical manifestations have been described. Adults and children might show similar symptoms, but rate for symptomatic ZIKV disease among children seems to be even lower than that for adults. Antibody-dependent enhancement in response to previous Dengue Virus infection can result in an increased disease severity. ZIKV is already included in the list of infectious diseases known to cause congenital malformations in the developing foetus during pregnancy. ZIKV infection has been linked to congenital ZIKV syndrome, including microcephaly, brain abnormalities, neural tube defects, early brain/eye malformations and other consequences of central nervous system dysfunction. In adults, Guillain-Barré syndrome and other neurologic diseases have been also associated with ZIKV infection.


Dengue Virus Bovine Viral Diarrhoea Virus ZIKV Infection Optic Nerve Hypoplasia Acute Inflammatory Demyelinating Polyradiculoneuropathy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© The Author(s) 2017

Authors and Affiliations

  • Marta Díaz-Menéndez
    • 1
    Email author
  • Clara Crespillo-Andújar
    • 1
  1. 1.Tropical Medicine DepartmentHospital Universitario La Paz-Carlos IIIMadridSpain

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