The Virus

  • Marta Díaz-MenéndezEmail author
  • Clara Crespillo-Andújar
Part of the SpringerBriefs in Immunology book series (BRIEFSIMMUN)


ZIKV is a member of the family Flaviviridae, genus Flavivirus. It’s a RNA virus with three structural proteins (capsid, pre-membrane and envelope). ZIKV has adapted to humans by losing a codon of the non-structural proteins NS1 of its genome, facilitating viral replication and increasing viral titters. ZIKV infects dermal cells and then migrates to lymph node and bloodstream, reaching different organs and tissues. There are identified three lineages: East African, West African, and Asian. Current outbreak clustered closely within the Asian lineage, and its introduction in the Americas may have taken place between May and December 2013. ZIKV is transmitted through mosquito bite, which carries the virus in its saliva, and replicate initially in dendritic cells near the site of inoculation and then spread to the blood, lymph nodes, bloodstream and finally to organs and tissues. Fetal affectation in congenital syndrome may be the result of destruction of germinal matrix in central nervous system, resulting in small brains and abnormal cortical gyration.


West Nile Virus Japanese Encephalitis Virus Japanese Encephalitis Virus Yellow Fever Virus ZIKV Infection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Ye Q, Liu Z-Y, Han J-F, Jiang T, Li X-F, Qin C-F (2016) Genomic characterization and phylogenetic analysis of Zika virus circulating in the Americas. Infect Genet Evol 43:43–49CrossRefPubMedGoogle Scholar
  2. 2.
    Enfissi A, Codrington J, Roosblad J, Kazanji M, Rousset D (2016) Zika virus genome from the Americas. Lancet 387(10015):227–228CrossRefPubMedGoogle Scholar
  3. 3.
    Kuno G, Chang GJJ (2007) Full-length sequencing and genomic characterization of Bagaza, Kedougou, and Zika viruses. Arch Virol 152(4):687–696CrossRefPubMedGoogle Scholar
  4. 4.
    Kostyuchenko VA, Lim EXY, Zhang S, Fibriansah G, Ng T-S, Ooi JSG et al (2016) Structure of the thermally stable Zika virus. Nat 533(7603):425–428Google Scholar
  5. 5.
    Faye O, Freire CCM, Iamarino A, Faye O, de Oliveira JVC, Diallo M, et al (2014) Molecular evolution of Zika virus during its emergence in the 20th century. PLoS Negl Trop Dis. 8(1):e2636 (Bird B, editor)Google Scholar
  6. 6.
    Sirohi D, Chen Z, Sun L, Klose T, Pierson TC, Rossmann MG et al (2016) The 3.8 A resolution cryo-EM structure of Zika virus. Sci 352(6284):467–470CrossRefGoogle Scholar
  7. 7.
    de Melo Freire CC, Iamarino A, de Lima Neto DF (2015) Spread of the pandemic Zika virus lineage is associated with NS1 codon usage adaptation in humans. bioRxivGoogle Scholar
  8. 8.
    Lanciotti RS, Kosoy OL, Laven JJ, Velez JO, Lambert AJ, Johnson AJ et al (2008) Genetic and serologic properties of Zika Virus Associated with an Epidemic, Yap State, Micronesia, 2007. Emerg Infect Dis 14(8):1232–1239CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Haddow AD, Schuh AJ, Yasuda CY, Kasper MR, Heang V, Huy R, et al (2012) Genetic characterization of Zika virus strains: geographic expansion of the Asian Lineage. PLoS Negl Trop Dis. 6(2):e1477 (Olson KE editor)Google Scholar
  10. 10.
    Baronti C, Piorkowski G, Charrel RN, Boubis L, Leparc-Goffart I, de Lamballerie X (2014) Complete coding sequence of zika virus from a French polynesia outbreak in 2013. Genome Announc 2(3)Google Scholar
  11. 11.
    McGrath EL, Rossi SL, Gao J, Widen SG, Grant AC, Dunn TJ et al (2017) Differential responses of human fetal brain neural stem cells to Zika Virus infection. Stem Cell Reports 8(3):715–727CrossRefPubMedPubMedCentralGoogle Scholar
  12. 12.
    Calvet G, Aguiar RS, Melo ASO, Sampaio SA, de Filippis I, Fabri A et al (2016) Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study. Lancet Infec Dis 16(6):653–660CrossRefGoogle Scholar
  13. 13.
    Faria NR, Azevedo RDSDS, Kraemer MUG, Souza R, Cunha MS, Hill SC et al (2016) Zika virus in the Americas: early epidemiological and genetic findings. Sci 352(6283):345–349CrossRefGoogle Scholar
  14. 14.
    Camacho E, Paternina-Gomez M, Blanco PJ, Osorio JE, Aliota MT (2016) Detection of autochthonous Zika Virus transmission in Sincelejo, Colombia. Emerg Infect Dis 22(5):927–929CrossRefPubMedPubMedCentralGoogle Scholar
  15. 15.
    Lanciotti RS, Lambert AJ, Holodniy M, Saavedra S, Signor LDCC (2016) Phylogeny of Zika Virus in Western Hemisphere, 2015. Emerg Infect Dis 22(5):933–935CrossRefPubMedPubMedCentralGoogle Scholar
  16. 16.
    Kochakarn T, Kotanan N, Kümpornsin K, Loesbanluechai D, Thammasatta M, Auewarakul P et al (2016) Comparative genome analysis between Southeast Asian and South American Zika viruses. Asian Pac J Trop Med. 9(11):1048–1054CrossRefPubMedGoogle Scholar
  17. 17.
    Wong P-SJ, Li M-ZI, Chong C-S, Ng L-C, Tan C-H (2013) Aedes (Stegomyia) albopictus (Skuse): a potential vector of Zika Virus in Singapore. PLoS Negl Trop Dis 7(8):e2348 (Turell MJ, editor)Google Scholar
  18. 18.
    Li MI, Wong P-SJ, Ng L-C, Tan C-H (2012) Oral susceptibility of Singapore Aedes (Stegomyia) aegypti (Linnaeus) to Zika Virus. PLoS Negl Trop Dis 6(8):e1792 (Turell MJ, editor)Google Scholar
  19. 19.
    Martins VEP, Alencar CH, Kamimura MT, de Carvalho Araújo FM, De Simone SG, Dutra RF, et al (2012) Occurrence of natural vertical transmission of dengue-2 and dengue-3 viruses in Aedes aegypti and Aedes albopictus in Fortaleza, Ceará, Brazil. PLoS ONE. 7(7):e41386 (Vasilakis N, editor)Google Scholar
  20. 20.
    Briant L, Desprès P, Choumet V, Missé D (2014) Role of skin immune cells on the host susceptibility to mosquito-borne viruses. Virol 464–465:26–32CrossRefGoogle Scholar
  21. 21.
    Hamel R, Dejarnac O, Wichit S, Ekchariyawat P, Neyret A, Luplertlop N et al (2015) Biology of Zika Virus infection in human skin cells. J Virol 89(17):8880–8896CrossRefPubMedPubMedCentralGoogle Scholar
  22. 22.
    Rosenberg AZ, Yu W, Hill DA, Reyes CA, Schwartz DA (2017) Placental pathology of Zika virus: viral infection of the placenta induces villous stromal macrophage (Hofbauer Cell) proliferation and hyperplasia. Arch Pathol Lab Med 141(1):43–48CrossRefPubMedGoogle Scholar
  23. 23.
    Solomon IH, Milner DA (2016) Neuropathology of Zika Virus Infection. J Neuroinfect Dis 7(2)Google Scholar
  24. 24.
    Tang H, Hammack C, Ogden SC, Wen Z, Qian X, Li Y, et al (2016) Zika virus infects human cortical neural progenitors and attenuates their growth. Stem Cell. Elsevier Inc 1–5Google Scholar
  25. 25.
    Gilmore EC, Walsh CA (2012) Genetic causes of microcephaly and lessons for neuronal development. WIREs Dev Biol 2(4):461–478CrossRefGoogle Scholar

Copyright information

© The Author(s) 2017

Authors and Affiliations

  • Marta Díaz-Menéndez
    • 1
    Email author
  • Clara Crespillo-Andújar
    • 1
  1. 1.Tropical Medicine DepartmentHospital Universitario La Paz-Carlos IIIMadridSpain

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