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The Virus

  • Marta Díaz-MenéndezEmail author
  • Clara Crespillo-Andújar
Chapter
Part of the SpringerBriefs in Immunology book series (BRIEFSIMMUN)

Abstract

ZIKV is a member of the family Flaviviridae, genus Flavivirus. It’s a RNA virus with three structural proteins (capsid, pre-membrane and envelope). ZIKV has adapted to humans by losing a codon of the non-structural proteins NS1 of its genome, facilitating viral replication and increasing viral titters. ZIKV infects dermal cells and then migrates to lymph node and bloodstream, reaching different organs and tissues. There are identified three lineages: East African, West African, and Asian. Current outbreak clustered closely within the Asian lineage, and its introduction in the Americas may have taken place between May and December 2013. ZIKV is transmitted through mosquito bite, which carries the virus in its saliva, and replicate initially in dendritic cells near the site of inoculation and then spread to the blood, lymph nodes, bloodstream and finally to organs and tissues. Fetal affectation in congenital syndrome may be the result of destruction of germinal matrix in central nervous system, resulting in small brains and abnormal cortical gyration.

Keywords

West Nile Virus Japanese Encephalitis Virus Japanese Encephalitis Virus Yellow Fever Virus ZIKV Infection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© The Author(s) 2017

Authors and Affiliations

  • Marta Díaz-Menéndez
    • 1
    Email author
  • Clara Crespillo-Andújar
    • 1
  1. 1.Tropical Medicine DepartmentHospital Universitario La Paz-Carlos IIIMadridSpain

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