Zika virus (ZIKV) infection is an emerging mosquito-borne disease that has recently been described in geographical areas where previously didn’t exist. Two important outbreaks were described in Yap Island (2007) and in several Pacific islands (2013). In 2015 ZIKV arrived first to Brazil and later to all countries in the Americas (North, Centre and South) and Caribe. In February 2016, the World Health Organization declared ZIKV infection a Public Health Emergency of International Concern, due to the link to birth defects and neurologic abnormalities (mostly Guillain-Barre syndrome). Clinical manifestations of this infection varies from asymptomatic to self-limiting acute febrile syndrome and other symptoms similar to those caused by dengue or chikungunya. Zika is a disease of particular concern because the possibility of transmission not only by mosquito bite, but by unprotected sexual intercourse or during pregnancy. Also, there is a real risk of introduction in regions where suitable vector already exist. In this monography, scientific information available in multiple aspects of ZIKV infection (the virus, the vector, the disease or the diagnosis) is compiled. Also, specific information about the potential risk of introduction of the disease in Europe is analyzed.