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Withanolides: A Prospective Drug for Infectious and Tropical Diseases

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Book cover Science of Ashwagandha: Preventive and Therapeutic Potentials

Abstract

Withania somnifera (Ashwagandha) is a shrub plant from the family of Solanaceae and widely used by practitioners in the folk medicines as immune boosting agent. The medicinal properties of plants have been attributed due to the presence of steroidal lactones called as withanolides. Withanolides are a group of highly oxygenated steroids derived from a C28 ergostane skeleton and have attracted significant scientific interest due to their complex structural features and multiple bioactivities. Last one decade’s more than 130 new natural withanolides were isolated from Withania spp., and the scientist from the different field demonstrated that Ashwagandha possesses antioxidant, anti-inflammatory, antitumor, antimicrobial properties. This chapter briefly reviews the drug-likeness activity of withanolides against antibacterial, antifungal, antiparasitic diseases and more focussed on antileishmanial and immunomodulatory activities of withanolides.

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  1. Department of Animal Biology, University of Hyderabad, Prof. C.R. Rao Road, Gachibowli, Hyderabad, 500046, India

    Radheshyam Maurya

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  1. DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Biomedical Research Institute, National Institute of Advanced Industrial Science & Technology (AIST), Tsukuba, Ibaraki, Japan

    Sunil C. Kaul

  2. DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Biomedical Research Institute, National Institute of Advanced Industrial Science & Technology (AIST), Tsukuba, Ibaraki, Japan

    Renu Wadhwa

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Maurya, R. (2017). Withanolides: A Prospective Drug for Infectious and Tropical Diseases. In: Kaul, S., Wadhwa, R. (eds) Science of Ashwagandha: Preventive and Therapeutic Potentials. Springer, Cham. https://doi.org/10.1007/978-3-319-59192-6_5

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