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The Effects of Withaferin A on Normal and Malignant Immune Cells

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Book cover Science of Ashwagandha: Preventive and Therapeutic Potentials

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Abstract

Ashwagandha, an ayurvedic medicinal plant, has been found to be a major contributor in treating medical ailments. Ayurveda is one of the world’s oldest traditional medical systems originated in India through various indigenous theories, beliefs and experiences. Often translated as science of “ayus” (life) and “ved” (knowledge), it emphasizes the use of herbs and their derivatives for prevention of disease, rejuvenation of body systems, and improving the quality of life. In this chapter, we will discuss some of the immuno-modulatory effects of withaferin A (WFA) as well as its growth-inhibitory effects on B cell lymphoma, leukemia and myelodysplastic syndrome.

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Authors and Affiliations

  1. Department of Microbiology, Immunology and Molecular Genetics, Markey Cancer Center, University of Kentucky, Lexington, KY, 40536, USA

    Sara S. Alhakeem, Mary K. McKenna, Karine Z. Oben, Beth W. Gachuki, Sunil K. Noothi & Subbarao Bondada

  2. Department of Internal Medicine, Ohio State University, Columbus, OH, 43210, USA

    Natarajan Muthusamy

  3. Department of Radiation Medicine, Markey Cancer Center, University of Kentucky, Lexington, KY, USA

    Vivek M. Rangnekar

  4. Department of Pharmacology and Toxicology, and James Graham Brown Cancer Center, University of Louisville, Louisville, KY, 40202, USA

    Ramesh C. Gupta

Authors
  1. Sara S. Alhakeem
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  2. Mary K. McKenna
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  3. Karine Z. Oben
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  4. Beth W. Gachuki
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  5. Sunil K. Noothi
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  6. Natarajan Muthusamy
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  7. Vivek M. Rangnekar
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  8. Ramesh C. Gupta
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  9. Subbarao Bondada
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Corresponding author

Correspondence to Subbarao Bondada .

Editor information

Editors and Affiliations

  1. DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Biomedical Research Institute, National Institute of Advanced Industrial Science & Technology (AIST), Tsukuba, Ibaraki, Japan

    Sunil C. Kaul

  2. DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Biomedical Research Institute, National Institute of Advanced Industrial Science & Technology (AIST), Tsukuba, Ibaraki, Japan

    Renu Wadhwa

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Alhakeem, S.S. et al. (2017). The Effects of Withaferin A on Normal and Malignant Immune Cells. In: Kaul, S., Wadhwa, R. (eds) Science of Ashwagandha: Preventive and Therapeutic Potentials. Springer, Cham. https://doi.org/10.1007/978-3-319-59192-6_11

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