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Clinical Safety and Applications of Stem Cell Gene Therapy

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Safety, Ethics and Regulations

Part of the book series: Stem Cells in Clinical Applications ((SCCA))

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Abstract

Gene therapy is an exciting new field that has the potential to contribute to the treatment of many incurable diseases. Ensuring safety and efficacy are key objectives. Here we review the latest developments in gene therapy vectors, the stem cell transduction techniques, and the therapeutic applications under investigation. The development of stem cell gene therapies is complex and requires optimization of many diverse elements. Local and international consortia will facilitate the entry of these technologies into the clinic through the sharing of knowledge and provision of guidance and support.

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Authors and Affiliations

  1. Department of Immunology, Institute for Cellular and Molecular Medicine, SAMRC Extramural Unit for Stem Cell Research and Therapy, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa

    Carlo S. Jackson, Marco Alessandrini & Michael S. Pepper

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  1. Carlo S. Jackson
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  2. Marco Alessandrini
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  3. Michael S. Pepper
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Correspondence to Michael S. Pepper .

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  1. Stem Cell Institute, University of Science, Vietnam National University, Ho Chi Minh City, Vietnam

    Phuc Van Pham

  2. Centre for Education Studies, Faculty of Social Sciences, University of Warwick, Coventry, United Kingdom

    Achim Rosemann

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Jackson, C.S., Alessandrini, M., Pepper, M.S. (2017). Clinical Safety and Applications of Stem Cell Gene Therapy. In: Pham, P., Rosemann, A. (eds) Safety, Ethics and Regulations. Stem Cells in Clinical Applications. Springer, Cham. https://doi.org/10.1007/978-3-319-59165-0_3

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