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Oral and Maxillofacial Aspects of Bone Research

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Principles of Bone and Joint Research

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Abstract

Cleft lip and palate is the genetic malformation with the highest incidence of 1:700 of the face. It is the non-fusion of the body’s natural structures that form before birth and affects either the lip, the alveolus, or the palate. Periodontitis is the disease of the supporting tissues of the teeth leading to destruction of the alveolus and secondary edentulism. Osteonecrosis of the jaws related to medication like bisphosphonates (BP) and the RANKL-RANK antagonist denosumab influences bone metabolism and may lead to jaw necrosis, infection, and fracture. Since bone morphogenetic proteins (BMPs) increase the differentiation and proliferation of the mesenchymal stem cell line of osteoblasts, recently they became therapeutic targets to promote bone regeneration. BMPs are already applied for elective surgery in bone regenerative surgical procedures. The efficacy of these surgical procedures is of great scientific concern.

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References

  1. Medscape.

    Google Scholar 

  2. Hillig U. Lippen-Kiefer-Gaumen-Spalten: Klassifikation und Epidemiologie. Springer Verlag Fortschritte der Kieferorthopädie. 1991;52(4):230–6.

    Article  CAS  Google Scholar 

  3. Schwenzer N, Ehrenfeld M, Zahn- Mund-, Kiefer- und Heilkunde, Mund- Kiefer- Gesichtschirurgie, 4. vollständig überarbeitete und erweiterte Auflage, Kapitel 6 Lippen- Kiefer- Gaumenspalten, Georg Thieme Verlag KG. Stuttgart/New York. 1981, 2011.

    Google Scholar 

  4. Wikipedia.

    Google Scholar 

  5. Baron R. Anatomy and ultrastructure of bone. In: Favus MJ, editor. Primer on the metabolic bone diseases and disorders of mineral metabolism, vol. 3. 4th ed. Philadelphia: Lippincott Williams & Wilkins; 1999.

    Google Scholar 

  6. Fleisch H. Bisphosphonates in bone disease. From the laboratory to the patient. 3rd ed. New York: Parthenon Publishing Group; 1997.

    Google Scholar 

  7. Vos T, Flaxman AD, Naghavi M, Lozano R, Michaud C, Ezzati M, Shibuya K, Salomon JA, Abdalla S, Aboyans V, Abraham J, Ackerman I, Aggarwal R, Ahn SY, Ali MK, Almazroa MA, Alvarado M, Anderson HR, Anderson LM, Andrews KG, Atkinson C, Baddour LM, Bahalim AN, Barker-Collo S, Barrero LH, Bartels DH, Basáñez M-G, Baxter A, Bell ML, et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the global burden of disease study 2010. Lancet. 2012;380(9859):2163–96.

    Article  PubMed  Google Scholar 

  8. Newman GN, Takei HH, Carranza FA. Clinical Periodontology. PA, Philadelphia: WB Saunders Company; 2002.

    Google Scholar 

  9. Socransky SS, Haffajee AD. The bacterial etiology of destructive periodontal disease: current concepts. J Periodontol. 1992;63:322.

    Article  CAS  PubMed  Google Scholar 

  10. D'Aiuto F, Ready D, Tonetti MS. Periodontal disease and C-reactive protein-associated cardiovascular risk. J Periodontal Res. 2004;39(4):236–41.

    Article  PubMed  Google Scholar 

  11. Pussinen PJ, Alfthan G, Jousilahti P, Paju S, Tuomilehto J. Systemic exposure to Porphyromonas gingivalis predicts incident stroke. Atherosclerosis. 2007;193(1):222–8.

    Article  CAS  PubMed  Google Scholar 

  12. Pussinen PJ, Alfthan G, Tuomilehto J, Asikainen S, Jousilahti P. High serum antibody levels to Porphyromonas gingivalis predict myocardial infarction. Eur J Cardiovasc Prev Rehabil. 2004;11(5):408–11.

    Article  PubMed  Google Scholar 

  13. Ford PJ, Gemmell E, Timms P, Chan A, Preston FM, Seymour GJ. Anti-P. Gingivalis response correlates with atherosclerosis. J Dent Res. 2007;86(1):35–40.

    Google Scholar 

  14. Zadik Y, Bechor R, Galor S, Levin L. Periodontal disease might be associated even with impaired fasting glucose. Br Dent J. 2010;208(10):E20.

    Article  CAS  PubMed  Google Scholar 

  15. Zadik Y, Bechor R, Galor S, Justo D, Heruti RJ. Erectile dysfunction might be associated with chronic periodontal disease: two ends of the cardiovascular spectrum. J Sex Med. April 2009;6(4):1111–6.

    Article  PubMed  Google Scholar 

  16. Marx RE. Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic [letter]. J Oral Maxillofac Surg. 2003;61:1115–8.

    Article  PubMed  Google Scholar 

  17. Migliorati CA. Bisphosphanates and oral cavity cancer avascular bone necrosis (correspondence). J Clin Oncol. 2003;21:4253–4.

    Article  PubMed  Google Scholar 

  18. Wang J, Goodger NM, Pogrel MA. Osteonecrosis of the jaws associated with cancer chemotherapy. J Oral Maxillofac Surg. 2003;6:1104–7.

    Article  Google Scholar 

  19. Ruggiero SL, Mehrotra B, Rosenberg TJ, Engroff S. Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases. J Oral Maxillofac Surg. 2004;62:527–34.

    Article  PubMed  Google Scholar 

  20. Hellstein JW, Marek CL. Bisphosphonate osteochemonecrosis (bis-phossy jaw): is this phossy jaw of the 21st century? J Oral Maxillofac Surg. 2005;63:682–9.

    Article  PubMed  Google Scholar 

  21. Khan AA, Morrison A, Hanley DA, Felsenberg D, McCauley LK, O'Ryan F, Reid IR, Ruggiero SL, Taguchi A, Tetradis S, Watts NB, Brandi ML, Peters E, Guise T, Eastell R, Cheung AM, Morin SN, Masri B, Cooper C, Morgan SL, Obermayer-Pietsch B, Langdahl BL, Al Dabagh R, Davison KS, Kendler DL, Sándor GK, Josse RG, Bhandari M, El Rabbany M, Pierroz DD, Sulimani R, Saunders DP, Brown JP, Compston J, International Task Force on Osteonecrosis of the Jaw. Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus. J Bone Miner Res. 2015;30(1):3–23. doi:10.1002/jbmr.2405. Review.

    Article  PubMed  Google Scholar 

  22. Fleisch H. Introduction to bisphosphonates. History and functional mechanisms. Orthopade. 2007;36(2):103–4. 106-9

    Article  CAS  PubMed  Google Scholar 

  23. Lo JC, et al. Prevalence of osteonecrosis of the jaw in patients with oral bisphosphonate exposure. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons. 2010;68(2):243–53.

    Article  Google Scholar 

  24. Ruggiero SL, et al. American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaw - 2009 update. Aust Endod J. 2009;35(3):119–30.

    Google Scholar 

  25. Bamias A, Kastritis E, Bamia C, Moulopoulos L, Melakopoulos I, Bozas G, et al. Osteonecrosis of the jaw in cancer after treatment with bisphosphonates: incidence and risk factors. J Clin Oncol. 2005;23:8580–7.

    Article  PubMed  Google Scholar 

  26. Mücke T, Krestan CR, Mitchell DA, Kirschke JS, Wutzl A. Bisphosphonate and medication-related osteonecrosis of the jaw: a review. Semin Musculoskelet Radiol. 2016 Jul;20(3):305–14.

    Article  PubMed  Google Scholar 

  27. Advisory Task Force on Bisphosphonate-Related Ostenonecrosis of the Jaws, American Association of Oral and Maxillofacial Surgeons. American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws. J Oral Maxillofac Surg. 2007;65:369–76.

    Article  Google Scholar 

  28. Svejda B, Muschitz C, Gruber R, Brandtner C, Svejda C, Gasser RW, Santler G, Dimai HP. Positionspapier zur medikamentenassoziierten Osteonekrose des Kiefers (MRONJ). Wien Med Wochenschr. 2016;166:68–74.

    Article  CAS  PubMed  Google Scholar 

  29. Holzinger D, Seemann R, Klug C, Ewers R, Millesi G, Baumann A, Wutzl A. Long-term success of surgery in bisphosphonate-related osteonecrosis of the jaws (BRONJs). Oral Oncol. 2013 Jan;49(1):66–70.

    Article  PubMed  Google Scholar 

  30. Starck WJ, Epker BN. Failure of osseointegrated dental implants after bisphosphonate therapy for osteoporosis: a case report. Int J Oral Maxillofac Implants. 1995;10(1):74–8.

    CAS  PubMed  Google Scholar 

  31. Troeltzsch M, Cagna D, Stähler P, Probst F, Kaeppler G, Troeltzsch M, Ehrenfeld M, Otto S. Clinical features of peri-implant medication-related osteonecrosis of the jaw: Is there an association to peri-implantitis?. J Craniomaxillofac Surg. 2016. S1010–5182(16)30232–3.

    Google Scholar 

  32. Advisory Task Force on Bisphosphonate-Related Ostenonecrosis of the Jaws, American Association of Oral and Maxillofacial Surgeons. American Association of Oral and Maxillofacial Surgeons Position Paper on bisphosphonate-related osteonecrosis of the jaws. J Oral Maxillofac Surg. 2007;65(3):369–76.

    Article  Google Scholar 

  33. Holzinger D, Seemann R, Matoni N, Ewers R, Millesi W, Wutzl A. Effect of dental implants on bisphosphonate-related osteonecrosis of the jaws. J Oral Maxillofac Surg. 2014;72(10):1937.

    Article  PubMed  Google Scholar 

  34. Prieto-Alhambra D, et al. Association between bisphosphonate use and implant survival after primary total arthroplasty of the knee or hip: population based retrospective cohort study. BMJ. 2011;343:d7222.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Im GI, et al. Osteoblast proliferation and maturation by bisphosphonates. Biomaterials. 2004;25(18):4105–15.

    Article  CAS  PubMed  Google Scholar 

  36. Assael LA. Bisphosphonates and oral health: primer and an update for the practicing surgeon. Oral Maxillofac Surg Clin North Am. 2011;23(3):443–53.

    Article  PubMed  Google Scholar 

  37. Marx RE, Cillo JE Jr, Ulloa JJ. Oral bisphosphonate-induced osteonecrosis: risk factors, prediction of risk using serum CTX testing, prevention, and treatment. J Oral Maxillofac Surg. 2007;65(12):2397–410.

    Article  PubMed  Google Scholar 

  38. Khosla S, et al. Bisphosphonate-associated osteonecrosis of the jaw: report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res. 2007;22(10):1479–91.

    Article  PubMed  Google Scholar 

  39. Uyanne J, Calhoun CC, Le AD. Antiresorptive drug-related osteonecrosis of the jaw. Dent Clin N Am. 2014 Apr;58(2):369–84.

    Article  PubMed  Google Scholar 

  40. Sivolella S, Lumachi F, Stellini E, Favero L. Denosumab and anti-angiogenetic drug-related osteonecrosis of the jaw: an uncommon but potentially severe disease. Anticancer Res. 2013 May;33(5):1793–7.

    PubMed  Google Scholar 

  41. Wozney JM. The bone morphogenetic protein family and osteogenesis. Mol Reprod Dev. 1992;32:160–7.

    Article  CAS  PubMed  Google Scholar 

  42. Yamashita H, Ten Dijke P, Heldin CH, Miyazono K. Bone morphogenetic protein receptors. Bone. 1996;19:569–74.

    Article  CAS  PubMed  Google Scholar 

  43. Wozney JM, Rosen V, Celeste AJ, Mitsock LM, Whitters MJ, Kriz RW, Hewick RM, Wang EA. Novel regulators of bone formation: molecular clones and activities. Science. 1988;242:1528–34.

    Article  CAS  PubMed  Google Scholar 

  44. Hoodless PA, Haerry T, Abdollah S, Stapleton M, O'Connor MB, Attisano L, Wrana JL. MADR1, a MAD-related protein that functions in BMP2 signaling pathways. Cell. 1996;85:489–500.

    Article  CAS  PubMed  Google Scholar 

  45. Yamaguchi A, Ishizuya T, Kintou N, Wada Y, Katagiri T, Wozney JM, Rosen V, Yoshiki S. Effects of BMP-2, BMP-4, and BMP-6 on osteoblastic differentiation of bone marrow-derived stromal cell lines, ST2 and MC3T3-G2/PA6. Biochem Biophys Res Commun. 1996;220:366–71.

    Article  CAS  PubMed  Google Scholar 

  46. Hunziker EB. Mechanism of longitudinal bone growth and its regulation by growth plate chondrocytes. Microsc Res Tech. 1994;28:505–19.

    Article  CAS  PubMed  Google Scholar 

  47. Baron RE. Anatomy and ultrastructure of bone. In: Favus MJ, editor. Primer on the metabolic bone diseases and disorders of mineral metabolism. 3rd ed. New York: Lippincot-Raven; 1996. p. 3–10.

    Google Scholar 

  48. Fujioka-Kobayashi M, Sawada K, Kobayashi E, Schaller B, Zhang Y, Miron RJ. Osteogenic potential of rhBMP9 combined with a bovine-derived natural bone mineral scaffold compared to rhBMP2. Clin Oral Implants Res. 2017;28:381–7. doi:10.1111/clr.12804.

    Article  PubMed  Google Scholar 

  49. Jung RE, Glauser R, Scharer P, Hammerle CH, Sailer HF, Weber FE. Effect of rhBMP-2 on guided bone regeneration in humans. Clin Oral Implants Res. 2003;14:556–68.

    Article  PubMed  Google Scholar 

  50. Govender S, Csimma C, Genant HK, Valentin-Opran A, Amit Y, Arbel R, Aro H, Atar D, Bishay M, Borner MG, Chiron P, Choong P, Cinats J, Courtenay B, Feibel R, Geulette B, Gravel C, Haas N, Raschke M, Hammacher E, van der Velde D, Hardy P, Holt M, Josten C, Ketterl RL, Lindeque B, Lob G, Mathevon H, McCoy G, Marsh D, Miller R, Munting E, Oevre S, Nordsletten L, Patel A, Pohl A, Rennie W, Reynders P, Rommens PM, Rondia J, Rossouw WC, Daneel PJ, Ruff S, Ruter A, Santavirta S, Schildhauer TA, Gekle C, Schnettler R, Segal D, Seiler H, Snowdowne RB, Stapert J, Taglang G, Verdonk R, Vogels L, Weckbach A, Wentzensen A, Wisniewski T, BMP-2 Evaluation in Surgery for Tibial Trauma (BESTT) Study Group. Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patients. J Bone Joint Surg Am. 2002;84-A:2123–34.

    Article  PubMed  Google Scholar 

  51. Delawi D, Jacobs W, van Susante JL, Rillardon L, Prestamburgo D, Specchia N, Gay E, Verschoor N, Garcia-Fernandez C, Guerado E, Quarles van Ufford H, Kruyt MC, Dhert WJ, Oner FC. OP-1 compared with iliac crest Autograft in instrumented posterolateral fusion: a randomized, Multicenter non-inferiority trial. J Bone Joint Surg Am. 2016;98(6):441–8. doi:10.2106/JBJS.O.00209.

    Article  PubMed  Google Scholar 

  52. Cheng H, Jiang W, Phillips FM, Haydon RC, Peng Y, Zhou L, Luu HH, An N, Breyer B, Vanichakarn P, Szatkowski JP, Park JY, He TC. Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs). J Bone Joint Surg Am. 2003;85-A:1544–52.

    Article  PubMed  Google Scholar 

  53. Lieberman JR, Daluiski A, Einhorn TA. The role of growth factors in the repair of bone. Biology and clinical applications. J Bone Joint Surg Am. 2002;84-A:1032–44.

    Article  PubMed  Google Scholar 

  54. Wutzl A, Brozek W, Lernbass I, Rauner M, Hofbauer G, Schopper C, Watzinger F, Peterlik M, Pietschmann P. Bone morphogenetic proteins 5 and 6 stimulate osteoclast generation. J Biomed Mater Res A. 2006;77(1):75–83.

    Article  PubMed  Google Scholar 

  55. Yeh LC, Adamo ML, Olson MS, Lee JC. Osteogenic protein-1 and insulin-like growth factor I synergistically stimulate rat osteoblastic cell differentiation and proliferation. Endocrinology. 1997;138:4181–90.

    Article  CAS  PubMed  Google Scholar 

  56. Wutzl A, Rauner M, Seemann R, Millesi W, Krepler P, Pietschmann P, Ewers R. Bone morphogenetic proteins 2, 5, and 6 in combination stimulate osteoblasts but not osteoclasts in vitro. J Orthop Res. 2010 Nov;28(11):1431–9.

    Google Scholar 

  57. Mummaneni PV, Haid RW, Rodts GE. Lumbar interbody fusion: state-of-the-art technical advances. Invited submission from the joint section meeting on disorders of the spine and peripheral nerves. J Neurosurg Spine. 2004;1:24–30.

    Article  PubMed  Google Scholar 

  58. Becker J, Kirsch A, Schwarz F, Chatzinikolaidou M, Rothamel D, Lekovic V, Laub M, Jennissen HP. Bone apposition to titanium implants biocoated with recombinant human bone morphogenetic protein-2 (rhBMP-2). A pilot study in dogs. Clin Oral Investig. 2006;10(3):217–24.

    Article  PubMed  PubMed Central  Google Scholar 

  59. Jensen OT, Lehman H, Ringeman JL, Casap N. Fabrication of printed titanium shells for containment of BMP-2 composite graft materials for alveolar bone reconstruction. Int J Oral Maxillofac Implants. 2014 Jan-Feb;29(1):e103–5.

    Article  PubMed  Google Scholar 

  60. Warnke PH, Springer IN, Wiltfang J, Acil Y, Eufinger H, Wehmöller M, Russo PA, Bolte H, Sherry E, Behrens E, Terheyden H. Growth and transplantation of a custom vascularised bone graft in a man. Lancet. 2004;364(9436):766–70.

    Article  CAS  PubMed  Google Scholar 

  61. Carreira AC, Lojudice FH, Halcsik E, Navarro RD, Sogayar MC, Granjeiro JM. Bone morphogenetic proteins: facts, challenges, and future perspectives. J Dent Res. 2014;93(4):335–45.

    Article  CAS  PubMed  Google Scholar 

  62. Kim HJ, Chung JH, Shin SY, Shin SI, Kye SB, Kim NK, Kwon TG, Paeng JY, Kim JW, Oh OH, Kook MS, Yang HJ, Hwang SJ. Efficacy of rhBMP-2/hydroxyapatite on sinus floor augmentation: a Multicenter, randomized controlled clinical trial. J Dent Res. 2015;94(9 Suppl):158S–65S. doi:10.1177/0022034515594573.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Zahnarzt, Facharzt für Mund-, Kiefer- und Gesichtschirurgie, Karlsgasse 17, 3430, Tulln, Austria

    Arno Wutzl

  2. Trauma Centre Meidling, Kundratstrasse 37, 1120, Wien, Austria

    Arno Wutzl

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Correspondence to Arno Wutzl .

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  1. Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria

    Peter Pietschmann

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Wutzl, A. (2017). Oral and Maxillofacial Aspects of Bone Research. In: Pietschmann, P. (eds) Principles of Bone and Joint Research. Learning Materials in Biosciences. Springer, Cham. https://doi.org/10.1007/978-3-319-58955-8_8

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