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Principles of Bone and Joint Research pp 55–66Cite as

Bone Turnover Markers

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Abstract

Bone is a very active tissue that is constantly remodeled in order to adapt to mechanic or metabolic requirements. Since disturbances in bone remodeling may result in relevant skeletal diseases, there is great interest in tools to assess bone remodeling for scientific and clinical applications. Bone turnover markers (BTMs) are among these tools; this chapter presents established markers of bone resorption and bone formation and also selected novel markers. For each marker the biochemical background will be described; in addition you will learn about non-pathological and pathological conditions that lead to alterations of the levels of BTMs. Finally, strengths and weaknesses of the BTMs – especially with regard to their potential clinical applications – will be discussed.

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Author information

Authors and Affiliations

  1. Department of Physical Medicine, Rehabilitation and Occupational Medicine, Medical University of Vienna, Währinger Gürtel 18-20, A-1090 Wien, Vienna, Austria

    Katharina Kerschan-Schindl

  2. Department of Pathophysiology and Allergy Research; Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria

    Ursula Föger-Samwald & Peter Pietschmann

Authors
  1. Katharina Kerschan-Schindl
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  2. Ursula Föger-Samwald
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  3. Peter Pietschmann
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Corresponding author

Correspondence to Katharina Kerschan-Schindl .

Editor information

Editors and Affiliations

  1. Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria

    Peter Pietschmann

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Kerschan-Schindl, K., Föger-Samwald, U., Pietschmann, P. (2017). Bone Turnover Markers. In: Pietschmann, P. (eds) Principles of Bone and Joint Research. Learning Materials in Biosciences. Springer, Cham. https://doi.org/10.1007/978-3-319-58955-8_4

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