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Computational Biomechanics of Bone Adaptation by Remodeling

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Multiscale Mechanobiology of Bone Remodeling and Adaptation

Part of the book series: CISM International Centre for Mechanical Sciences ((CISM,volume 578))

Abstract

In bone remodeling, a variety of mechanical and biochemical signaling occurs among osteoclasts and osteoblasts, which are responsible for bone resorption and formation, and osteocytes, which are believed to have a mechanosensing function. Biomechanics research incorporating mathematical modeling and computer simulations is being conducted in order to understand the functional adaptation of bone structure by remodeling that can be observed at a macroscopic level resulted from the complex interaction among these signals at molecular and cellular levels.

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Notes

  1. 1.

    Sections 4 and 5 in this chapter were modified from Ref. [29] with permission from Springer.

  2. 2.

    Section 6 was modified from Ref. [32] with permission of Springer.

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Authors and Affiliations

  1. Department of Biosystems Science, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan

    Taiji Adachi & Yoshitaka Kameo

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  1. Taiji Adachi
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  2. Yoshitaka Kameo
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Correspondence to Taiji Adachi .

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  1. Biomedical Engineering & Spinal Disorder, Queensland University of Technology, Brisbane, Queensland, Australia

    Peter Pivonka

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Adachi, T., Kameo, Y. (2018). Computational Biomechanics of Bone Adaptation by Remodeling. In: Pivonka, P. (eds) Multiscale Mechanobiology of Bone Remodeling and Adaptation. CISM International Centre for Mechanical Sciences, vol 578. Springer, Cham. https://doi.org/10.1007/978-3-319-58845-2_5

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  • DOI: https://doi.org/10.1007/978-3-319-58845-2_5

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