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A Role for Phosphodiesterase 11A (PDE11A) in the Formation of Social Memories and the Stabilization of Mood

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Phosphodiesterases: CNS Functions and Diseases

Part of the book series: Advances in Neurobiology ((NEUROBIOL,volume 17))

Abstract

The most recently discovered 3′,5′-cyclic nucleotide phosphodiesterase family is the Phosphodiesterase 11 (PDE11) family, which is encoded by a single gene PDE11A. PDE11A is a dual-specific PDE, breaking down both cAMP and cGMP. There are four PDE11A splice variants (PDE11A1-4) with distinct tissue expression profiles and unique N-terminal regulatory regions, suggesting that each isoform could be individually targeted with a small molecule or biologic. PDE11A4 is the PDE11A isoform expressed in brain and is found in the hippocampal formation of humans and rodents. Studies in rodents show that PDE11A4 mRNA expression in brain is, in fact, restricted to the hippocampal formation (CA1, possibly CA2, subiculum, and the adjacently connected amygdalohippocampal area). Within the hippocampal formation of rodents, PDE11A4 protein is expressed in neurons but not astrocytes, with a distribution across nuclear, cytoplasmic, and membrane compartments. This subcellular localization of PDE11A4 is altered in response to social experience in mouse, and in vitro studies show the compartmentalization of PDE11A4 is controlled, at least in part, by homodimerization and N-terminal phosphorylation. PDE11A4 expression dramatically increases in the hippocampus with age in the rodent hippocampus, from early postnatal life to late aging, suggesting PDE11A4 function may evolve across the lifespan. Interestingly, PDE11A4 protein shows a three to tenfold enrichment in the rodent ventral hippocampal formation (VHIPP; a.k.a. anterior in primates) versus dorsal hippocampal formation (DHIPP). Consistent with this enrichment in VHIPP, studies in knockout mice show that PDE11A regulates the formation of social memories and the stabilization of mood and is a critical mechanism by which social experience feeds back to modify the brain and subsequent social behaviors. PDE11A4 likely controls behavior by regulating hippocampal glutamatergic, oxytocin, and cytokine signaling, as well as protein translation. Given its unique tissue distribution and relatively selective effects on behavior, PDE11A may represent a novel therapeutic target for neuropsychiatric, neurodevelopmental, or age-related disorders. Therapeutically targeting PDE11A4 may be a way to selectively restore aberrant cyclic nucleotide signaling in the hippocampal formation while leaving the rest of the brain and periphery untouched, thus, relieving deficits while avoiding unwanted side effects.

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References

  • Ahmed NS, Gary BD, Tinsley HN, Piazza GA, Laufer S, Abadi AH. Design, synthesis and structure-activity relationship of functionalized tetrahydro-beta-carboline derivatives as novel PDE5 inhibitors. Arch Pharm (Weinheim). 2011;344:149–57.

    Article  CAS  Google Scholar 

  • Ahmed NS, Ali AH, El-Nashar SM, Gary BD, Fajardo AM, Tinsley HN, Piazza GA, Negri M, Abadi AH. Exploring the PDE5 H-pocket by ensemble docking and structure-based design and synthesis of novel beta-carboline derivatives. Eur J Med Chem. 2012;57:329–43.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Aitchison K, Serretti A, Goldman D, Curran S, Drago A, Malhotra AK. The 8th annual pharmacogenetics in psychiatry meeting report. Pharmacogenomics J. 2009;9:358–61.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Alda M, Shao L, Wang JF, Lopez de Lara C, Jaitovich-Groisman I, Lebel V, Sun X, Duffy A, Grof P, Rouleau GA, Turecki G, Young LT. Alterations in phosphorylated cAMP response element-binding protein (pCREB) signaling: an endophenotype of lithium-responsive bipolar disorder? Bipolar Disord. 2013;15:824–31.

    Article  CAS  PubMed  Google Scholar 

  • Alevizaki M, Stratakis CA. Multiple endocrine neoplasias: advances and challenges for the future. J Intern Med. 2009;266:1–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Almeida MQ, Stratakis CA. How does cAMP/protein kinase A signaling lead to tumors in the adrenal cortex and other tissues? Mol Cell Endocrinol. 2011;336:162–8.

    Article  CAS  PubMed  Google Scholar 

  • Avissar S, Schreiber G. The involvement of G proteins and regulators of receptor-G protein coupling in the pathophysiology, diagnosis and treatment of mood disorders. Clin Chim Acta. 2006;366:37–47.

    Article  CAS  PubMed  Google Scholar 

  • Avissar S, Nechamkin Y, Barki-Harrington L, Roitman G, Schreiber G. Differential G protein measures in mononuclear leukocytes of patients with bipolar mood disorder are state dependent. J Affect Disord. 1997;43:85–93.

    Article  CAS  PubMed  Google Scholar 

  • Avissar S, Barki-Harrington L, Nechamkin Y, Roitman G, Schreiber G. Elevated dopamine receptor-coupled G(s) protein measures in mononuclear leukocytes of patients with schizophrenia. Schizophr Res. 2001a;47:37–47.

    Article  CAS  PubMed  Google Scholar 

  • Avissar S, Roitman G, Schreiber G. Differential effects of the antipsychotics haloperidol and clozapine on G protein measures in mononuclear leukocytes of patients with schizophrenia. Cell Mol Neurobiol. 2001b;21:799–811.

    Article  CAS  PubMed  Google Scholar 

  • Baltrons MA, Pifarre P, Ferrer I, Carot JM, Garcia A. Reduced expression of NO-sensitive guanylyl cyclase in reactive astrocytes of Alzheimer disease, Creutzfeldt-Jakob disease, and multiple sclerosis brains. Neurobiol Dis. 2004;17:462–72.

    Article  CAS  PubMed  Google Scholar 

  • Bast T, Feldon J. Hippocampal modulation of sensorimotor processes. Prog Neurobiol. 2003;70:319–45.

    Article  CAS  PubMed  Google Scholar 

  • Bazhin AV, Kahnert S, Kimpfler S, Schadendorf D, Umansky V. Distinct metabolism of cyclic adenosine monophosphate in regulatory and helper CD4+ T cells. Mol Immunol. 2010;47:678–84.

    Article  CAS  PubMed  Google Scholar 

  • Beavo JA, Hardman JG, Sutherland EW. Stimulation of adenosine 3′,5′-monophosphate hydrolysis by guanosine 3′,5′-monophosphate. J Biol Chem. 1971;246:3841–6.

    CAS  PubMed  Google Scholar 

  • Behrendt R-P. Neuroanatomy of social behavior: an evolutionary and psychoanalytic perspective. London: Karnac Books; 2011.

    Google Scholar 

  • Belmaker RH, Ebstein RP, Biederman J, Stern R, Berman M, van Praag HM. The effect of L-dopa and propranolol on human CSF cyclic nucleotides. Psychopharmacology. 1978;58:307–10.

    Article  CAS  PubMed  Google Scholar 

  • Bimpaki EI, Nesterova M, Stratakis CA. Abnormalities of cAMP signaling are present in adrenocortical lesions associated with ACTH-independent Cushing syndrome despite the absence of mutations in known genes. Eur J Endocrinol. 2009;161:153–61.

    Google Scholar 

  • Bonkale WL, Fastbom J, Wiehager B, Ravid R, Winblad B, Cowburn RF. Impaired G-protein-stimulated adenylyl cyclase activity in Alzheimer’s disease brain is not accompanied by reduced cyclic-AMP-dependent protein kinase A activity. Brain Res. 1996;737:155–61.

    Article  CAS  PubMed  Google Scholar 

  • Bonkale WL, Cowburn RF, Ohm TG, Bogdanovic N, Fastbom J. A quantitative autoradiographic study of [3H]cAMP binding to cytosolic and particulate protein kinase A in post-mortem brain staged for Alzheimer’s disease neurofibrillary changes and amyloid deposits. Brain Res. 1999;818:383–96.

    Article  CAS  PubMed  Google Scholar 

  • Bowers MB Jr, Study RE. Cerebrospinal fluid cyclic AMP and acid monoamine metabolites following probenecid: studies in psychiatric patients. Psychopharmacology. 1979;62:17–22.

    Article  CAS  PubMed  Google Scholar 

  • Brietzke E, Stertz L, Fernandes BS, Kauer-Sant'anna M, Mascarenhas M, Escosteguy Vargas A, Chies JA, Kapczinski F. Comparison of cytokine levels in depressed, manic and euthymic patients with bipolar disorder. J Affect Disord. 2009;116:214–7.

    Article  CAS  PubMed  Google Scholar 

  • Cabanero M, Laje G, Detera-Wadleigh S, McMahon FJ. Association study of phosphodiesterase genes in the Sequenced Treatment Alternatives to Relieve Depression sample. Pharmacogenet Genomics. 2009;19:235–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Carney JA, Gaillard RC, Bertherat J, Stratakis CA. Familial micronodular adrenocortical disease, Cushing syndrome, and mutations of the gene encoding phosphodiesterase 11A4 (PDE11A). 2010; 34: 547-555.

    Google Scholar 

  • Casebolt TL, Jope RS. Effects of chronic lithium treatment on protein kinase C and cyclic AMP-dependent protein phosphorylation. Biol Psychiatry. 1991;29:233–43.

    Article  CAS  PubMed  Google Scholar 

  • Ceyhan O, Birsoy K, Hoffman CS. Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen. Chem Biol. 2012;19:155–63.

    Article  CAS  PubMed  Google Scholar 

  • Chang A, Li PP, Warsh JJ. Altered cAMP-dependent protein kinase subunit immunolabeling in post-mortem brain from patients with bipolar affective disorder.[erratum appears in J Neurochem 2003 Apr;85(1):286]. J Neurochem. 2003;84:781–91.

    Article  CAS  PubMed  Google Scholar 

  • Coon H, Darlington T, Pimentel R, Smith KR, Huff CD, Hu H, Jerominski L, Hansen J, Klein M, Callor WB, Byrd J, Bakian A, Crowell SE, McMahon WM, Rajamanickam V, Camp NJ, McGlade E, Yurgelun-Todd D, Grey T, Gray D. Genetic risk factors in two Utah pedigrees at high risk for suicide. Transl Psychiatry. 2013;3:e325.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Couzin J. Science and commerce. Gene tests for psychiatric risk polarize researchers. Science. 2008;319:274–7.

    Article  CAS  PubMed  Google Scholar 

  • Cowburn RF, Marcusson JO, Eriksson A, Wiehager B, O’Neill C. Adenylyl cyclase activity and G-protein subunit levels in postmortem frontal cortex of suicide victims. Brain Res. 1994;633:297–304.

    Article  CAS  PubMed  Google Scholar 

  • D’Amours MR, Cote RH. Regulation of photoreceptor phosphodiesterase catalysis by its non-catalytic cGMP-binding sites. Biochem J. 1999;340(Pt 3):863–9.

    Article  PubMed  PubMed Central  Google Scholar 

  • DeWan AT, Triche EW, Xu X, Hsu LI, Zhao C, Belanger K, Hellenbrand K, Willis-Owen SA, Moffatt M, Cookson WO, Himes BE, Weiss ST, Gauderman WJ, Baurley JW, Gilliland F, Wilk JB, O'Connor GT, Strachan DP, Hoh J, Bracken MB. PDE11A associations with asthma: results of a genome-wide association scan. J Allergy Clin Immunol, 2010; 126: 871-73.e9.

    Google Scholar 

  • Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK, Lanctot KL. A meta-analysis of cytokines in major depression. Biol Psychiatry. 2010;67:446–57.

    Article  CAS  PubMed  Google Scholar 

  • Dowlatshahi D, MacQueen GM, Wang JF, Reiach JS, Young LT. G Protein-coupled cyclic AMP signaling in postmortem brain of subjects with mood disorders: effects of diagnosis, suicide, and treatment at the time of death. J Neurochem. 1999;73:1121–6.

    Article  CAS  PubMed  Google Scholar 

  • Ebstein RP, Biederman J, Rimon R, Zohar J, Belmaker RH. Cyclic GMP in the CSF of patients with schizophrenia before and after neuroleptic treatment. Psychopharmacology. 1976;51:71–4.

    Article  CAS  PubMed  Google Scholar 

  • Ebstein RP, Knafo A, Mankuta D, Chew SH, Lai PS. The contributions of oxytocin and vasopressin pathway genes to human behavior. Horm Behav. 2012;61:359–79.

    Article  CAS  PubMed  Google Scholar 

  • Edmunds CE, Simpson LJ, Sale JE. PCNA ubiquitination and REV1 define temporally distinct mechanisms for controlling translesion synthesis in the avian cell line DT40. Mol Cell. 2008;30:519–29.

    Article  CAS  PubMed  Google Scholar 

  • Fanselow MS, Dong HW. Are the dorsal and ventral hippocampus functionally distinct structures? Neuron. 2010;65:7–19.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fatemi SH, Reutiman TJ, Folsom TD, Lee S. Phosphodiesterase-4A expression is reduced in cerebella of patients with bipolar disorder. Psychiatr Genet. 2008;18:282–8.

    Article  PubMed  Google Scholar 

  • Fatemi SH, Folsom TD, Reutiman TJ, Vazquez G. Phosphodiesterase signaling system is disrupted in the cerebella of subjects with schizophrenia, bipolar disorder, and major depression. 2010a; 119: 266-267.

    Google Scholar 

  • Fatemi SH, Folsom TD, Reutiman TJ, Vazquez G. Phosphodiesterase signaling system is disrupted in the cerebella of subjects with schizophrenia, bipolar disorder, and major depression. Schizophr Res. 2010b;119:266–7.

    Article  PubMed  Google Scholar 

  • Faucz FR, Horvath A, Rothenbuhler A, Almeida MQ, Libe R, Raffin-Sanson ML, Bertherat J, Carraro DM, Soares FA, Molina GD, Campos AH, Alexandre RB, Bendhack ML, Nesterova M, Stratakis CA. Phosphodiesterase 11A (PDE11A) genetic variants may increase susceptibility to prostatic cancer. J Clin Endocrinol Metabol. 2011;96:E135–40.

    Article  CAS  Google Scholar 

  • Fawcett L, Baxendale R, Stacey P, McGrouther C, Harrow I, Soderling S, Hetman J, Beavo JA, Phillips SC. Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A. Proc Natl Acad Sci U S A. 2000;97(7):3702.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ferguson JN, Young LJ, Hearn EF, Matzuk MM, Insel TR, Winslow JT. Social amnesia in mice lacking the oxytocin gene. Nat Genet. 2000;25:284–8.

    Article  CAS  PubMed  Google Scholar 

  • Fields A, Li PP, Kish SJ, Warsh JJ. Increased cyclic AMP-dependent protein kinase activity in postmortem brain from patients with bipolar affective disorder. J Neurochem. 1999;73:1704–10.

    Article  CAS  PubMed  Google Scholar 

  • Forget H, Lacroix A, Somma M, Cohen H. Cognitive decline in patients with Cushing's syndrome. J Int Neuropsychol Soc. 2000;6:20–9.

    CAS  PubMed  Google Scholar 

  • Fowler CJ, Cowburn RF, Garlind A, Winblad B, O’Neill C. Disturbances in signal transduction mechanisms in Alzheimer’s disease. Mol Cell Biochem. 1995;149–150:287–92.

    Article  PubMed  Google Scholar 

  • Francis SH, Blount MA, Corbin JD. Mammalian cyclic nucleotide phosphodiesterases: molecular mechanisms and physiological functions. Physiol Rev. 2011;91:651–90.

    Article  CAS  PubMed  Google Scholar 

  • Garver DL, Johnson C, Kanter DR. Schizophrenia and reduced cyclic AMP production: evidence for the role of receptor-linked events. Life Sci. 1982;31:1987–92.

    Article  CAS  PubMed  Google Scholar 

  • Gattaz WF, Cramer H, Beckmann H. Low CSF concentrations of cyclic GMP in schizophrenia. Br J Psychiatry. 1983;142:288–91.

    Article  CAS  PubMed  Google Scholar 

  • Ghose S, Chin R, Gallegos A, Roberts R, Coyle J, Tamminga C. Localization of NAAG-related gene expression deficits to the anterior hippocampus in schizophrenia. Schizophr Res. 2009;111:131–7.

    Article  PubMed  PubMed Central  Google Scholar 

  • Goldman MB, Wang L, Wachi C, Daudi S, Csernansky J, Marlow-O'Connor M, Keedy S, Torres I. Structural pathology underlying neuroendocrine dysfunction in schizophrenia. Behav Brain Res. 2011;218:106–13.

    Article  PubMed  Google Scholar 

  • Greene MH, Kratz CP, Mai PL, Mueller C, Peters JA, Bratslavsky G, Ling A, Choyke PM, Premkumar A, Bracci J, Watkins RJ, McMaster ML, Korde LA. Familial testicular germ cell tumors in adults: 2010 summary of genetic risk factors and clinical phenotype. 2010; 17: R109-R121.

    Google Scholar 

  • Gross-Langenhoff M, Hofbauer K, Weber J, Schultz A, Schultz JE. cAMP is a ligand for the tandem GAF domain of human phosphodiesterase 10 and cGMP for the tandem GAF domain of phosphodiesterase 11. J Biol Chem. 2006;281:2841–6.

    Article  CAS  PubMed  Google Scholar 

  • Gross-Langenhoff M, Stenzl A, Altenberend F, Schultz A, Schultz JE. The properties of phosphodiesterase 11A4 GAF domains are regulated by modifications in its N-terminal domain. FEBS J. 2008;275:1643–50.

    Article  CAS  PubMed  Google Scholar 

  • Gruber AJ, Calhoon GG, Shusterman I, Schoenbaum G, Roesch MR, O'Donnell P. More is less: a disinhibited prefrontal cortex impairs cognitive flexibility. J Neurosci. 2010;30:17102–10.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gurguis GN, Turkka J, George DT, Linnoila M. Beta-adrenoreceptor coupling to GS protein in alcohol dependence, panic disorder, and patients with both conditions. Neuropsychopharmacology. 1997;16:69–76.

    Article  CAS  PubMed  Google Scholar 

  • Gurguis GN, Blakeley JE, Antai-Otong D, Vo SP, Orsulak PJ, Petty F, Rush AJ. Adrenergic receptor function in panic disorder. II. Neutrophil beta 2 receptors: Gs protein coupling, effects of imipramine treatment and relationship to treatment outcome. J Psychiatr Res. 1999a;33:309–22.

    Article  CAS  PubMed  Google Scholar 

  • Gurguis GN, Vo SP, Blakeley J, Orsulak PJ, Rush AJ. Characteristics of norepinephrine and clonidine displacement of [3H]yohimbine binding to platelet alpha2-adrenoreceptors in healthy volunteers. Psychiatry Res. 1999b;85:305–14.

    Article  CAS  PubMed  Google Scholar 

  • Gusev PA, Cui C, Alkon DL, Gubin AN. Topography of Arc/Arg3.1 mRNA expression in the dorsal and ventral hippocampus induced by recent and remote spatial memory recall: dissociation of CA3 and CA1 activation. J Neurosci. 2005;25:9384–97.

    Article  CAS  PubMed  Google Scholar 

  • Hall J, Whalley HC, Marwick K, McKirdy J, Sussmann J, Romaniuk L, Johnstone EC, Wan HI, McIntosh AM, Lawrie SM. Hippocampal function in schizophrenia and bipolar disorder. Psychol Med. 2010;40:761–70.

    Article  CAS  PubMed  Google Scholar 

  • Hegde S, Capell WR, Ibrahim BA, Klett J, Patel NS, Sougiannis AT, et al. Phosphodiesterase 11A4 (PDE11A4) in hippocampus is required for the consolidation of social but not non-social memories. Neuropsychopharmacology. 2016a; 41:2920–31.

    Google Scholar 

  • Hegde SO, Ji H, Oliver D, Patel NS, Poupore N, Shtutman M, Kelly MP. PDE11A is required for intact social behaviors and is a key mechanism by which social experience sculpts the brain. Neuroscience. 2016b;335:151–69.

    Article  CAS  PubMed  Google Scholar 

  • Heikaus CC, Pandit J, Klevit RE. Cyclic nucleotide binding GAF domains from phosphodiesterases: structural and mechanistic insights. Structure. 2009;17:1551–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hetman JM, Robas N, Baxendale R, Fidock M, Phillips SC, Soderling SH, Beavo JA. Cloning and characterization of two splice variants of human phosphodiesterase 11A. Proc Natl Acad Sci U S A. 2000;97:12891–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Horvath A, Giatzakis C, Robinson-White A, Boikos S, Levine E, Griffin K, Stein E, Kamvissi V, Soni P, Bossis I, de Herder W, Carney JA, Bertherat J, Gregersen PK, Remmers EF, Stratakis CA. Adrenal hyperplasia and adenomas are associated with inhibition of phosphodiesterase 11A in carriers of PDE11A sequence variants that are frequent in the population. Cancer Res. 2006a;66:11571–5.

    Article  CAS  PubMed  Google Scholar 

  • Horvath A, Boikos S, Giatzakis C, Robinson-White A, Groussin L, Griffin KJ, Stein E, Levine E, Delimpasi G, Hsiao HP, Keil M, Heyerdahl S, Matyakhina L, Libe R, Fratticci A, Kirschner LS, Cramer K, Gaillard RC, Bertagna X, Carney JA, Bertherat J, Bossis I, Stratakis CA. A genome-wide scan identifies mutations in the gene encoding phosphodiesterase 11A4 (PDE11A) in individuals with adrenocortical hyperplasia. Nat Genet. 2006b;38:794–800.

    Article  CAS  PubMed  Google Scholar 

  • Horvath A, Korde L, Greene MH, Libe R, Osorio P, Faucz FR, Raffin-Sanson ML, Tsang KM, Drori-Herishanu L, Patronas Y, Remmers EF, Nikita ME, Moran J, Greene J, Nesterova M, Merino M, Bertherat J, Stratakis CA. Functional phosphodiesterase 11A mutations may modify the risk of familial and bilateral testicular germ cell tumors. Cancer Res. 2009;69:5301–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jager R, Schwede F, Genieser HG, Koesling D, Russwurm M. Activation of PDE2 and PDE5 by specific GAF ligands: delayed activation of PDE5. Br J Pharmacol. 2010;161:1645–60.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Jager R, Russwurm C, Schwede F, Genieser HG, Koesling D, Russwurm M. Activation of PDE10 and PDE11 phosphodiesterases. J Biol Chem. 2012;287:1210–9.

    Article  PubMed  CAS  Google Scholar 

  • Jansen KL, Faull RL, Storey P, Leslie RA. Loss of sigma binding sites in the CA1 area of the anterior hippocampus in Alzheimer’s disease correlates with CA1 pyramidal cell loss. Brain Res. 1993;623:299–302.

    Article  CAS  PubMed  Google Scholar 

  • Jensen JB, Mork A. Altered protein phosphorylation in the rat brain following chronic lithium and carbamazepine treatments. Eur Neuropsychopharmacol. 1997;7:173–9.

    Article  CAS  PubMed  Google Scholar 

  • Jessen F, Scheef L, Germeshausen L, Tawo Y, Kockler M, Kuhn KU, Maier W, Schild HH, Heun R. Reduced hippocampal activation during encoding and recognition of words in schizophrenia patients. Am J Psychiatry. 2003;160:1305–12.

    Article  PubMed  Google Scholar 

  • Kafka MS, van Kammen DP. alpha-Adrenergic receptor function in schizophrenia. Receptor number, cyclic adenosine monophosphate production, adenylate cyclase activity, and effect of drugs. Arch Gen Psychiatry. 1983;40:264–70.

    Article  CAS  PubMed  Google Scholar 

  • Kafka MS, van Kammen DP, Bunney WE Jr. Reduced cyclic AMP production in the blood platelets from schizophrenic patients. Am J Psychiatry. 1979;136:685–7.

    Article  CAS  PubMed  Google Scholar 

  • Kafka MS, Kleinman JE, Karson CN, Wyatt RJ. Alpha-adrenergic receptors and cyclic AMP production in a group of schizophrenic patients. Hillside J Clin Psychiatry. 1986;8:15–24.

    CAS  PubMed  Google Scholar 

  • Kaiya H. Second messenger imbalance hypothesis of schizophrenia. Prostaglandins Leukot Essent Fatty Acids. 1992;46:33–8.

    Article  CAS  PubMed  Google Scholar 

  • Kaiya H, Ofuji M, Nozaki M, Tsurumi K. Platelet prostaglandin E1 hyposensitivity in schizophrenia: decrease in cyclic AMP formation and in inhibitory effects on aggregation. Psychopharmacol Bull. 1990;26:381–4.

    CAS  PubMed  Google Scholar 

  • Kang WH. Assaying the SCF platelets cyclic nucleotides of schizophrenics and analyzing its correlation with pathopschological factors. Zhonghua Shen Jing Jing Shen Ke Za Zhi. 1990;23:266–8. 318

    CAS  PubMed  Google Scholar 

  • Kanof PD, Johns C, Davidson M, Siever LJ, Coccaro EF, Davis KL. Prostaglandin receptor sensitivity in psychiatric disorders. Arch Gen Psychiatry. 1986;43:987–93.

    Article  CAS  PubMed  Google Scholar 

  • Kanof PD, Davidson M, Johns CA, Mohs RC, Davis KL. Clinical correlates of platelet prostaglandin receptor subsensitivity in schizophrenia. Am J Psychiatry. 1987;144:1556–60.

    Article  CAS  PubMed  Google Scholar 

  • Kanof PD, Coccaro EF, Johns CA, Davidson M, Siever LJ, Davis KL. Cyclic-AMP production by polymorphonuclear leukocytes in psychiatric disorders. Biol Psychiatry. 1989;25:413–20.

    Article  CAS  PubMed  Google Scholar 

  • Kelly MP. Putting together the pieces of phosphodiesterase distribution patterns in the brain: a jigsaw puzzle of cyclic nucleotide regulation. In: Brandon NJ, West AR, editors. Cyclic nucleotide phosphodiesterases in the central nervous system: from biology to disease. Wiley, Hoboken; 2014.

    Google Scholar 

  • Kelly MP. Does phosphodiesterase 11A (PDE11A) hold promise as a future therapeutic target? Curr Pharm Des. 2015;21:389–416.

    Article  CAS  PubMed  Google Scholar 

  • Kelly MP, Brandon NJ. Differential function of phosphodiesterase families in the brain: gaining insights through the use of genetically modified animals. Prog Brain Res. 2009;179:67–73.

    Article  CAS  PubMed  Google Scholar 

  • Kelly MP, Logue SF, Brennan J, Day JP, Lakkaraju S, Jiang L, Zhong X, Tam M, Sukoff Rizzo SJ, Platt BJ, Dwyer JM, Neal S, Pulito VL, Agostino MJ, Grauer SM, Navarra RL, Kelley C, Comery TA, Murrills RJ, Houslay MD, Brandon NJ. Phosphodiesterase 11A in brain is enriched in ventral hippocampus and deletion causes psychiatric disease-related phenotypes. Proc Natl Acad Sci U S A. 2010;107:8457–62.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kelly MP, Adamowicz W, Bove S, Hartman AJ, Mariga A, Pathak G, Reinhart V, Romegialli A, Kleiman RJ. Select 3′,5′-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain. Cell Signal. 2014;26:383–97.

    Article  CAS  PubMed  Google Scholar 

  • Kelsoe J. Method to predict response to treatment for psychiatric illnesses. In: Office UPT, editors. The regents of the University of California. Oakland, USA; 2010. p. 1.

    Google Scholar 

  • Keravis T, Lugnier C. Cyclic nucleotide phosphodiesterases (PDE) and peptide motifs. Curr Pharm Des. 2010;16:1114–25.

    Article  CAS  PubMed  Google Scholar 

  • Khandaker GM, Pearson RM, Zammit S, Lewis G, Jones PB. Association of serum interleukin 6 and C-reactive protein in childhood with depression and psychosis in young adult life: a population-based longitudinal study. JAMA Psychiat. 2014;71:1121–8.

    Article  CAS  Google Scholar 

  • Laakso MP, Frisoni GB, Kononen M, Mikkonen M, Beltramello A, Geroldi C, Bianchetti A, Trabucchi M, Soininen H, Aronen HJ. Hippocampus and entorhinal cortex in frontotemporal dementia and Alzheimer’s disease: a morphometric MRI study. Biol Psychiatry. 2000;47:1056–63.

    Article  CAS  PubMed  Google Scholar 

  • Laje G, Perlis RH, Rush AJ, McMahon FJ. Pharmacogenetics studies in STAR*D: strengths, limitations, and results. Psychiatr Serv. 2009;60:1446–57.

    Article  PubMed  PubMed Central  Google Scholar 

  • Lee JM, Kim SH, Jang DP, Ha TH, Kim JJ, Kim IY, Kwon JS, Kim SI. Deformable model with surface registration for hippocampal shape deformity analysis in schizophrenia. NeuroImage. 2004;22:831–40.

    Article  PubMed  Google Scholar 

  • Leube DT, Weis S, Freymann K, Erb M, Jessen F, Heun R, Grodd W, Kircher TT. Neural correlates of verbal episodic memory in patients with MCI and Alzheimer's disease--a VBM study. Int J Geriatr Psychiatry. 2008;23:1114–8.

    Article  PubMed  Google Scholar 

  • Libe R, Fratticci A, Coste J, Tissier F, Horvath A, Ragazzon B, Rene-Corail F, Groussin L, Bertagna X, Raffin-Sanson ML, Stratakis CA, Bertherat J. Phosphodiesterase 11A (PDE11A) and genetic predisposition to adrenocortical tumors. Clin Cancer Res. 2008;14:4016–24.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Libe R, Horvath A, Vezzosi D, Fratticci A, Coste J, Perlemoine K, Ragazzon B, Guillaud-Bataille M, Groussin L, Clauser E, Raffin-Sanson ML, Siegel J, Moran J, Drori-Herishanu L, Faucz FR, Lodish M, Nesterova M, Bertagna X, Bertherat J, Stratakis CA. Frequent phosphodiesterase 11A gene (PDE11A) defects in patients with Carney complex (CNC) caused by PRKAR1A mutations: PDE11A may contribute to adrenal and testicular tumors in CNC as a modifier of the phenotype. J Clin Endocrinol Metab. 2011;96:E208–14.

    Article  CAS  PubMed  Google Scholar 

  • Louiset E, Gobet F, Libe R, Horvath A, Renouf S, Cariou J, Rothenbuhler A, Bertherat J, Clauser E, Grise P, Stratakis CA, Kuhn JM, Lefebvre H. ACTH-independent Cushing’s syndrome with bilateral micronodular adrenal hyperplasia and ectopic adrenocortical adenoma. J Clin Endocrinol Metab. 2010;95:18–24.

    Article  CAS  PubMed  Google Scholar 

  • Lukas M, Neumann ID. Oxytocin and vasopressin in rodent behaviors related to social dysfunctions in autism spectrum disorders. Behav Brain Res. 2013;251:85–94.

    Article  CAS  PubMed  Google Scholar 

  • Luo HR, Wu GS, Dong C, Arcos-Burgos M, Ribeiro L, Licinio J, Wong ML. Association of PDE11A global haplotype with major depression and antidepressant drug response. 2009a; 5: 163-170.

    Google Scholar 

  • Luo HR, GS W, Dong C, Arcos-Burgos M, Ribeiro L, Licinio J, Wong ML. Association of PDE11A global haplotype with major depression and antidepressant drug response. Neuropsychiatr Dis Treat. 2009b;5:163–70.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Maes M, Bosmans E, Calabrese J, Smith R, Meltzer HY. Interleukin-2 and interleukin-6 in schizophrenia and mania: effects of neuroleptics and mood stabilizers. J Psychiatr Res. 1995;29:141–52.

    Article  CAS  PubMed  Google Scholar 

  • Maes M, Bosmans E, De Jongh R, Kenis G, Vandoolaeghe E, Neels H. Increased serum IL-6 and IL-1 receptor antagonist concentrations in major depression and treatment resistant depression. Cytokine. 1997;9:853–8.

    Article  CAS  PubMed  Google Scholar 

  • Maheu FS, Mazzone L, Merke DP, Keil MF, Stratakis CA, Pine DS, Ernst M. Altered amygdala and hippocampus function in adolescents with hypercortisolemia: a functional magnetic resonance imaging study of Cushing syndrome. Dev Psychopathol. 2008;20:1177–89.

    Article  PubMed  PubMed Central  Google Scholar 

  • Makhlouf A, Kshirsagar A, Niederberger C. Phosphodiesterase 11: a brief review of structure, expression and function. Int J Impot Res. 2006;18:501–9.

    Article  CAS  PubMed  Google Scholar 

  • Malhi GS, Tanious M, Das P, Coulston CM, Berk M. Potential mechanisms of action of lithium in bipolar disorder. Current understanding. CNS Drugs. 2013;27:135–53.

    Article  PubMed  Google Scholar 

  • Marquis JP, Goulet S, Dore FY. Neonatal ventral hippocampus lesions disrupt extra-dimensional shift and alter dendritic spine density in the medial prefrontal cortex of juvenile rats. Neurobiol Learn Mem. 2008;90:339–46.

    Article  PubMed  Google Scholar 

  • Martinez M, Fernandez E, Frank A, Guaza C, de la Fuente M, Hernanz A. Increased cerebrospinal fluid cAMP levels in Alzheimer’s disease. Brain Res. 1999;846:265–7.

    Article  CAS  PubMed  Google Scholar 

  • Martinez SE, AY W, Glavas NA, Tang XB, Turley S, Hol WG, Beavo JA. The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding. Proc Natl Acad Sci U S A. 2002;99:13260–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Matthiesen K, Nielsen J. Binding of cyclic nucleotides to phosphodiesterase 10A and 11A GAF domains does not stimulate catalytic activity. Biochem J. 2009;423:401–9.

    Article  CAS  PubMed  Google Scholar 

  • Memo M, Kleinman JE, Hanbauer I. Coupling of dopamine D1 recognition sites with adenylate cyclase in nuclei accumbens and caudatus of schizophrenics. Science. 1983;221:1304–7.

    Article  CAS  PubMed  Google Scholar 

  • Mertens J, Wang QW, Kim Y, DX Y, Pham S, Yang B, Zheng Y, Diffenderfer KE, Zhang J, Soltani S, Eames T, Schafer ST, Boyer L, Marchetto MC, Nurnberger JI, Calabrese JR, Odegaard KJ, McCarthy MJ, Zandi PP, Alba M, Nievergelt CM, Pharmacogenomics of Bipolar Disorder Study, Mi S, Brennand KJ, Kelsoe JR, Gage FH, Yao J. Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder. Nature. 2015;527:95–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mohamed HA, Girgis NM, Wilcken R, Bauer MR, Tinsley HN, Gary BD, Piazza GA, Boeckler FM, Abadi AH. Synthesis and molecular modeling of novel tetrahydro-beta-carboline derivatives with phosphodiesterase 5 inhibitory and anticancer properties. J Med Chem. 2011;54:495–509.

    Article  CAS  PubMed  Google Scholar 

  • Mori S, Tardito D, Dorigo A, Zanardi R, Smeraldi E, Racagni G, Perez J. Effects of lithium on cAMP-dependent protein kinase in rat brain. Neuropsychopharmacology. 1998;19:233–40.

    Article  CAS  PubMed  Google Scholar 

  • Moser MB, Moser EI. Functional differentiation in the hippocampus. Hippocampus. 1998;8:608–19.

    Article  CAS  PubMed  Google Scholar 

  • Nesvaderani M, Matsumoto I, Sivagnanasundaram S. Anterior hippocampus in schizophrenia pathogenesis: molecular evidence from a proteome study. Aust N Z J Psychiatry. 2009;43:310–22.

    Article  PubMed  Google Scholar 

  • Niculescu AB, Levey DF, Phalen PL, Le-Niculescu H, Dainton HD, Jain N, Belanger E, James A, George S, Weber H, Graham DL, Schweitzer R, Ladd TB, Learman R, Niculescu EM, Vanipenta NP, Khan FN, Mullen J, Shankar G, Cook S, Humbert C, Ballew A, Yard M, Gelbart T, Shekhar A, Schork NJ, Kurian SM, Sandusky GE, Salomon DR. Understanding and predicting suicidality using a combined genomic and clinical risk assessment approach. Mol Psychiatry. 2015;20:1266–85.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nijholt IM, Dolga AM, Ostroveanu A, Luiten PG, Schmidt M, Eisel UL. Neuronal AKAP150 coordinates PKA and Epac-mediated PKB/Akt phosphorylation. 2008; 20: 1715-1724.

    Google Scholar 

  • Ofuji M, Kaiya H, Nozaki M, Tsurumi K. Platelet prostaglandin E1 hyposensitivity in schizophrenia: reduction of prostaglandin E1- or forskolin-stimulated cyclic AMP response in platelets. Life Sci. 1989;45:2135–40.

    Article  CAS  PubMed  Google Scholar 

  • Ohm TG, Bohl J, Lemmer B. Reduced cAMP-signal transduction in postmortem hippocampus of demented old people. Prog Clin Biol Res. 1989;317:501–9.

    CAS  PubMed  Google Scholar 

  • Ohm TG, Bohl J, Lemmer B. Reduced basal and stimulated (isoprenaline, Gpp(NH)p, forskolin) adenylate cyclase activity in Alzheimer’s disease correlated with histopathological changes. Brain Res. 1991;540:229–36.

    Article  CAS  PubMed  Google Scholar 

  • Oki NO, Motsinger-Reif AA, Antas PR, Levy S, Holland SM, Sterling TR. Novel human genetic variants associated with extrapulmonary tuberculosis: a pilot genome wide association study. BMC Res Notes. 2011;4:28.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pan JQ, Lewis MC, Ketterman JK, Clore EL, Riley M, Richards KR, Berry-Scott E, Liu X, Wagner FF, Holson EB, Neve RL, Biechele TL, Moon RT, Scolnick EM, Petryshen TL, Haggarty SJ. AKT kinase activity is required for lithium to modulate mood-related behaviors in mice. Neuropsychopharmacology. 2011;36:1397–411.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Papatheodoropoulos C, Kostopoulos G. Dorsal-ventral differentiation of short-term synaptic plasticity in rat CA1 hippocampal region. Neurosci Lett. 2000;286:57–60.

    Article  CAS  PubMed  Google Scholar 

  • Pathak GH, Fisher JL, Wilson S, Kelly MP, et al. Homodimerization and N-terminal phosphorylation control the subcellular localization of PDE11A4. Soc Neurosci. 2015;524:17.

    Google Scholar 

  • Pathak G, Agostino MJ, Bishara K, Capell WR, Fisher JL, Hegde S, Ibrahim BA, Pilarzyk K, Sabin C, Tuczkewycz T, Wilson S, Kelly MP. PDE11A negatively regulates lithium responsivity. Mol Psychiatry. 2016. Epub ahead of print DOI: MP.2016.155.

    Google Scholar 

  • Pegues MP, Rogers LJ, Amend D, Vinogradov S, Deicken RF. Anterior hippocampal volume reduction in male patients with schizophrenia. Schizophr Res. 2003;60:105–15.

    Article  PubMed  Google Scholar 

  • Perlis RH, Fijal B, Dharia S, Heinloth AN, Houston JP. Failure to replicate genetic associations with antidepressant treatment response in duloxetine-treated patients. Biol Psychiatry. 2010;67:1110–3.

    Article  CAS  PubMed  Google Scholar 

  • Quiroz YT, Budson AE, Celone K, Ruiz A, Newmark R, Castrillon G, Lopera F, Stern CE. Hippocampal hyperactivation in presymptomatic familial Alzheimer’s disease. Ann Neurol. 2010;68:865–75.

    Article  PubMed  PubMed Central  Google Scholar 

  • Rahman S, Li PP, Young LT, Kofman O, Kish SJ, Warsh JJ. Reduced [3H]cyclic AMP binding in postmortem brain from subjects with bipolar affective disorder. J Neurochem. 1997;68:297–304.

    Article  CAS  PubMed  Google Scholar 

  • Rajarethinam R, DeQuardo JR, Miedler J, Arndt S, Kirbat R, Brunberg JA, Tandon R. Hippocampus and amygdala in schizophrenia: assessment of the relationship of neuroanatomy to psychopathology. Psychiatry Res. 2001;108:79–87.

    Article  CAS  PubMed  Google Scholar 

  • Rametti G, Segarra N, Junque C, Bargallo N, Caldu X, Ibarretxe N, Bernardo M. Left posterior hippocampal density reduction using VBM and stereological MRI procedures in schizophrenia. Schizophr Res. 2007;96:62–71.

    Article  PubMed  Google Scholar 

  • Roman F, Soumireu-Mourat B. Behavioral dissociation of anterodorsal and posteroventral hippocampus by subseizure stimulation in mice. Brain Res. 1988;443:149–58.

    Article  CAS  PubMed  Google Scholar 

  • Rusch N, Tebartz van Elst L, Valerius G, Buchert M, Thiel T, Ebert D, Hennig J, Olbrich HM. Neurochemical and structural correlates of executive dysfunction in schizophrenia. Schizophr Res. 2008;99:155–63.

    Article  PubMed  Google Scholar 

  • Schobel SA, Kelly MA, Corcoran CM, Van Heertum K, Seckinger R, Goetz R, Harkavy-Friedman J, Malaspina D. Anterior hippocampal and orbitofrontal cortical structural brain abnormalities in association with cognitive deficits in schizophrenia. Schizophr Res. 2009a;114:110–8.

    Article  PubMed  PubMed Central  Google Scholar 

  • Schobel SA, Lewandowski NM, Corcoran CM, Moore H, Brown T, Malaspina D, Small SA. Differential targeting of the CA1 subfield of the hippocampal formation by schizophrenia and related psychotic disorders. Arch Gen Psychiatry. 2009b;66:938–46.

    Article  PubMed  PubMed Central  Google Scholar 

  • Schreiber G, Avissar S. Lithium sensitive G protein hyperfunction: a dynamic model for the pathogenesis of bipolar affective disorder. Med Hypotheses. 1991;35:237–43.

    Article  CAS  PubMed  Google Scholar 

  • Schreiber G, Avissar S, Danon A, Belmaker RH. Hyperfunctional G proteins in mononuclear leukocytes of patients with mania. Biol Psychiatry. 1991;29:273–80.

    Article  CAS  PubMed  Google Scholar 

  • Shanahan C, Gibson GE, Cowburn RF, Johnston JA, Wiehager B, Lannfelt L, O'Neill C. G protein subunit levels in fibroblasts from familial Alzheimer’s disease patients: lower levels of high molecular weight Gs alpha isoform in patients with decreased beta-adrenergic receptor stimulated cAMP formation. Neurosci Lett. 1997;232:33–6.

    Article  CAS  PubMed  Google Scholar 

  • Shenton ME, Kikinis R, Jolesz FA, Pollak SD, LeMay M, Wible CG, Hokama H, Martin J, Metcalf D, Coleman M, et al. Abnormalities of the left temporal lobe and thought disorder in schizophrenia. A quantitative magnetic resonance imaging study. N Engl J Med. 1992;327:604–12.

    Article  CAS  PubMed  Google Scholar 

  • Simon NM, McNamara K, Chow CW, Maser RS, Papakostas GI, Pollack MH, Nierenberg AA, Fava M, Wong KK. A detailed examination of cytokine abnormalities in Major Depressive Disorder. Eur Neuropsychopharmacol. 2008;18(3):230.

    Article  CAS  PubMed  Google Scholar 

  • Starkman MN, Gebarski SS, Berent S, Schteingart DE. Hippocampal formation volume, memory dysfunction, and cortisol levels in patients with Cushing’s syndrome. Biol Psychiatry. 1992;32:756–65.

    Article  CAS  PubMed  Google Scholar 

  • Starkman MN, Giordani B, Gebarski SS, Berent S, Schork MA, Schteingart DE. Decrease in cortisol reverses human hippocampal atrophy following treatment of Cushing’s disease. Biol Psychiatry. 1999;46:1595–602.

    Article  CAS  PubMed  Google Scholar 

  • Starkman MN, Giordani B, Berent S, Schork MA, Schteingart DE. Elevated cortisol levels in Cushing’s disease are associated with cognitive decrements. Psychosom Med. 2001;63:985–93.

    Article  CAS  PubMed  Google Scholar 

  • Stoesz BM, Hare JF, Snow WM. Neurophysiological mechanisms underlying affiliative social behavior: insights from comparative research. Neurosci Biobehav Rev. 2013;37:123–32.

    Article  CAS  PubMed  Google Scholar 

  • Suddath RL, Christison GW, Torrey EF, Casanova MF, Weinberger DR. Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia. N Engl J Med. 1990;322:789–94.

    Article  CAS  PubMed  Google Scholar 

  • Sun X, Young LT, Wang JF, Grof P, Turecki G, Rouleau GA, Alda M. Identification of lithium-regulated genes in cultured lymphoblasts of lithium responsive subjects with bipolar disorder. Neuropsychopharmacology. 2004;29:799–804.

    Article  CAS  PubMed  Google Scholar 

  • Tipton LA, Christensen L, Blacher J. Friendship quality in adolescents with and without an intellectual disability. J Appl Res Intellect Disabil. 2013;26:522–32.

    PubMed  Google Scholar 

  • Tseng KY, Lewis BL, Hashimoto T, Sesack SR, Kloc M, Lewis DA, O'Donnell P. A neonatal ventral hippocampal lesion causes functional deficits in adult prefrontal cortical interneurons. J Neurosci. 2008;28:12691–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Turetsky BI, Moberg PJ. An odor-specific threshold deficit implicates abnormal intracellular cyclic AMP signaling in schizophrenia. Am J Psychiatry. 2009;166:226–33.

    Article  PubMed  Google Scholar 

  • Vezzosi D, Libe R, Baudry C, Rizk-Rabin M, Horvath A, Levy I, Rene-Corail F, Ragazzon B, Stratakis CA, Vandecasteele G, Bertherat J. Phosphodiesterase 11A (PDE11A) gene defects in patients with acth-independent macronodular adrenal hyperplasia (AIMAH): functional variants may contribute to genetic susceptibility of bilateral adrenal tumors. J Clin Endocrinol Metab. 2012;97:E2063–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Viero C, Shibuya I, Kitamura N, Verkhratsky A, Fujihara H, Katoh A, Ueta Y, Zingg HH, Chvatal A, Sykova E, Dayanithi G. REVIEW: Oxytocin: Crossing the bridge between basic science and pharmacotherapy. CNS Neurosci Ther. 2010;16:e138–56.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Watanabe S, Iga J, Nishi A, Numata S, Kinoshita M, Kikuchi K, Nakataki M, Ohmori T. Microarray analysis of global gene expression in leukocytes following lithium treatment. Hum Psychopharmacol. 2014;29:190–8.

    Article  CAS  PubMed  Google Scholar 

  • Weeks JL 2nd, Zoraghi R, Francis SH, Corbin JD. N-Terminal domain of phosphodiesterase-11A4 (PDE11A4) decreases affinity of the catalytic site for substrates and tadalafil, and is involved in oligomerization. Biochemistry. 2007;46:10353–64.

    Article  CAS  PubMed  Google Scholar 

  • Weeks JL 2nd, Corbin JD, Francis SH. Interactions between cyclic nucleotide phosphodiesterase 11 catalytic site and substrates or tadalafil and role of a critical Gln-869 hydrogen bond. J Pharmacol Exp Ther. 2009;331:133–41.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Witwicka H, Kobialka M, Siednienko J, Mitkiewicz M, Gorczyca WA. Expression and activity of cGMP-dependent phosphodiesterases is up-regulated by lipopolysaccharide (LPS) in rat peritoneal macrophages. Biochim Biophys Acta. 2007;1773:209–18.

    Article  CAS  PubMed  Google Scholar 

  • Wong ML, Whelan F, Deloukas P, Whittaker P, Delgado M, Cantor RM, McCann SM, Licinio J, Wong ML, Whelan F, Deloukas P, Whittaker P, Delgado M, Cantor RM, McCann SM, Licinio J. Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment response. Proc Natl Acad Sci U S A. 2006;103:15124–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Xu Y, Zhang HT, O'Donnell JM. Phosphodiesterases in the central nervous system: implications in mood and cognitive disorders. Handb Exp Pharmacol. 2011:447–85.

    Google Scholar 

  • Yakushev I, Muller MJ, Lorscheider M, Schermuly I, Weibrich C, Dellani PR, Hammers A, Stoeter P, Fellgiebel A. Increased hippocampal head diffusivity predicts impaired episodic memory performance in early Alzheimer’s disease. Neuropsychologia. 2010;48:1447–53.

    Article  PubMed  Google Scholar 

  • Yakushev I, Schreckenberger M, Muller MJ, Schermuly I, Cumming P, Stoeter P, Gerhard A, Fellgiebel A. Functional implications of hippocampal degeneration in early Alzheimer’s disease: a combined DTI and PET study. Eur J Nucl Med Mol Imaging. 2011a;38:2219–27.

    Article  PubMed  Google Scholar 

  • Yakushev I, Gerhard A, Muller MJ, Lorscheider M, Buchholz HG, Schermuly I, Weibrich C, Hammers A, Stoeter P, Schreckenberger M, Fellgiebel A. Relationships between hippocampal microstructure, metabolism, and function in early Alzheimer’ disease. Brain Struct Funct. 2011b;216:219–26.

    Article  PubMed  Google Scholar 

  • Yamamoto M, Gotz ME, Ozawa H, Luckhaus C, Saito T, Rosler M, Riederer P. Hippocampal level of neural specific adenylyl cyclase type I is decreased in Alzheimer's disease. Biochim Biophys Acta. 2000;1535:60–8.

    Article  CAS  PubMed  Google Scholar 

  • Young LT, Li PP, Kish SJ, Siu KP, Warsh JJ. Postmortem cerebral cortex Gs alpha-subunit levels are elevated in bipolar affective disorder. Brain Res. 1991;553:323–6.

    Article  CAS  PubMed  Google Scholar 

  • Young LT, Li PP, Kish SJ, Siu KP, Kamble A, Hornykiewicz O, Warsh JJ. Cerebral cortex Gs alpha protein levels and forskolin-stimulated cyclic AMP formation are increased in bipolar affective disorder. J Neurochem. 1993;61:890–8.

    Article  CAS  PubMed  Google Scholar 

  • Young LT, Li PP, Kamble A, Siu KP, Warsh JJ. Mononuclear leukocyte levels of G proteins in depressed patients with bipolar disorder or major depressive disorder. Am J Psychiatry. 1994;151:594–6.

    Article  CAS  PubMed  Google Scholar 

  • Yuasa K, Kotera J, Fujishige K, Michibata H, Sasaki T, Omori K. Isolation and characterization of two novel phosphodiesterase PDE11A variants showing unique structure and tissue-specific expression. J Biol Chem. 2000;275:31469–79.

    Article  CAS  PubMed  Google Scholar 

  • Yuasa K, Ohgaru T, Asahina M, Omori K. Identification of rat cyclic nucleotide phosphodiesterase 11A (PDE11A): comparison of rat and human PDE11A splicing variants. Eur J Biochem. 2001a;268:4440–8.

    Article  CAS  PubMed  Google Scholar 

  • Yuasa K, Kanoh Y, Okumura K, Omori K. Genomic organization of the human phosphodiesterase PDE11A gene. Evolutionary relatedness with other PDEs containing GAF domains. Eur J Biochem. 2001b;268:168–78.

    Article  CAS  PubMed  Google Scholar 

  • Zhou Y, Shu N, Liu Y, Song M, Hao Y, Liu H, Yu C, Liu Z, Jiang T. Altered resting-state functional connectivity and anatomical connectivity of hippocampus in schizophrenia. Schizophr Res. 2008;100:120–32.

    Article  PubMed  Google Scholar 

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Acknowledgements

The author would like to thank Baher Ibrahim for conducting the immunofluorescence shown herein. Support received from a Research Starter Grant in Pharmacology & Toxicology from the PhRMA Foundation, an ASPIRE award from the Office of the Vice President for Research from the University of South Carolina, a Research Development Fund Award from the University of South Carolina School of Medicine, a NARSAD Young Investigator Award from the Brain & Behavior Research Foundation, and 1R01MH101130 from NIMH (all awards to MPK).

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The authors declare that they have no conflicts of interest.

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  1. Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, 6439 Garners Ferry Road, VA Bldg 1, 3rd Floor, D-12, Columbia, SC, 29209, USA

    Michy P. Kelly

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  1. Department of Behavioral Medicine and Psychiatry; Department of Physiology and Pharmacology; Institute of Pharmacology, West Virginia University Health Sciences Center; Taishan Medical University, Morgantown; Taian, China, West Virginia, USA

    Han-Ting Zhang

  2. School of Pharmacy and Pharmaceutical Sciences, University at Buffalo The State University of New York, Buffalo, New York, USA

    Ying Xu

  3. School of Pharmacy and Pharmaceutical Sciences, University at Buffalo The State University of New York, Buffalo, New York, USA

    James M. O'Donnell

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Kelly, M.P. (2017). A Role for Phosphodiesterase 11A (PDE11A) in the Formation of Social Memories and the Stabilization of Mood. In: Zhang, HT., Xu, Y., O'Donnell, J. (eds) Phosphodiesterases: CNS Functions and Diseases. Advances in Neurobiology, vol 17. Springer, Cham. https://doi.org/10.1007/978-3-319-58811-7_8

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