Acquired Immunity in Metal Allergy: T Cell Responses

  • By Trine Hilkjær Petersen
  • Carsten Geisler
  • Charlotte Menné Bonefeld


Allergies to metals are common, with nickel allergy being the most frequent form of contact allergy. Contact allergies are classified as delayed-type hypersensitivity reactions in which T cells are the key players. In this chapter, we describe how metals are presented to T cells and discuss the current literature on the role of CD4+ and CD8+ T cells in contact allergies to metals.


CD4+ T cells CD8+ T cells IFN-γ IL-17A IL-10 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • By Trine Hilkjær Petersen
    • 1
  • Carsten Geisler
    • 1
  • Charlotte Menné Bonefeld
    • 1
  1. 1.Department of Immunology and Microbiology, Faculty of Health and Medical SciencesUniversity of CopenhagenCopenhagenDenmark

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