Metal Allergy pp 507-513 | Cite as

Metal Allergy and Atopic Dermatitis

  • John McFadden


Atopic dermatitis is characterised by protein allergy, a skewed immune system towards Th2, dry itchy skin with barrier impairment and a flexural dermatitis. There are conflicting reports as to whether metal allergy is more or less common in patients with atopic dermatitis compared to non-atopic individuals. Under experimental conditions, atopic dermatitis subjects are less readily sensitised to contact allergens; however, metal ions may be able to penetrate the atopic dermatitis skin barrier with greater ease. False-positive/irritant patch test reactions to metal are more common in atopic dermatitis individuals. Similarly, irritant contact reactions to metal may be more common in atopic dermatitis, and allergic contact dermatitis may more readily spread from the site of origin.


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Cutaneous AllergySt John’s Institute of DermatologySt Thomas’ HospitalUK

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