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Metal Allergy: Aluminium

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Metal Allergy

Abstract

Aluminium is one of the most abundant metals in the earth’s crust, and aluminium compounds are widely used. Aluminium is considered to be a weak allergen, but contact allergy to aluminium has been more frequently reported in recent years. The most important routes of sensitization to aluminium are aluminium-containing vaccines, hyposensitization with aluminium-adsorbed extracts and contact with aluminium in antiperspirants and other skin products. In this chapter, the literature on aluminium contact sensitization, patch testing and management considerations is reviewed.

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References

  1. Lidén C, Bruze M, Menné T. Metals. In: Menné T, Lepoittevin J-P, Frosch PJ, editors. Contact dermatitis. 4th ed. NewYork: Springer; 2006. p. 537–68.

    Chapter  Google Scholar 

  2. Bergfors E, Trollfors B. Sixty-four children with persistent itching nodules and contact allergy to aluminium after vaccination with aluminium—absorbed vaccines-prognosis and outcome after booster vacccination. Eur J Pediatr. 2013;172(2):171–7.

    Article  CAS  Google Scholar 

  3. Siemund I, Zimerson E, Hindsén M, Bruze M. Establishing aluminium contact allergy. Contact Dermatitis. 2012;67:162–70.

    Article  CAS  Google Scholar 

  4. Clemmensen O, Knudsen HE. Contact sensitivity to aluminium in a patient hyposensitized with aluminium precipitated grass pollen. Contact Dermatitis. 1980;6:305–8.

    Article  CAS  Google Scholar 

  5. Bruze M, Lundh K, Gruvberger B, Hindsén M. Aluminium chloride hexahydrat is insufficent to trace contact allergy to aluminium. Contact Dermatitis. 2008;59:183–4.

    Article  Google Scholar 

  6. Frost L, Johansen P, Pedersen S, Veien N, Ostergaard PA, Nielsen MH. Persistent subcutaneous nodules in children hyposensitized with aluminium-containing allergen extracts. Allergy. 1985;40:368–72.

    Article  CAS  Google Scholar 

  7. Lopez S, Pelaez A, Navorro A, Montesinos E, Morales C, Carda C. Aluminium allergy in patient hyposensitized with aluminium-precipitated antigen extracts. Contact Dermatitis. 1994;31:37–40.

    Article  CAS  Google Scholar 

  8. Hindsén M. Contact allergy to aluminium in patients hyposensitized with aluminium-containing hyposensitizing extracts. Contact Dermatitis. 2005;53:301–2.

    Article  Google Scholar 

  9. Netterlid E, Hindsén M, Björk J, Ekqvist S, Guner N, Henriksson KÅ, Bruze M. There is an association between contact allergy to aluminium and persistent sucutaneous nodules in children undergoing hypersensitization therapy. Contact Dermatitis. 2009;60:41–9.

    Article  Google Scholar 

  10. Netterlid E, Hindsén M, Siemund I, Björk J, Werner S, Jacobsson H, Guner N, Bruze M. Does allergen-specific immunotherapy induce contact allergy to aluminium? Acta Derm Venereol. 2013;93:50–6.

    Article  CAS  Google Scholar 

  11. Bergfors E, Trollfors B, Inerot A. Uexpected high incidence of persistent iching nodules and delayed hypersensitivityto aluminiumin children after the use of absorbed vaccines from a single manufacturen. Vaccine. 2003;22:64–9.

    Article  Google Scholar 

  12. Siemund I, Hindsén M, Zimerson E, Bruze M. Individual variation in aluminium patch test reactivity. Abstract ESCD Manchester. 2016.

    Google Scholar 

  13. Lidholm AG, Bergfors E, Inerot A, Blomgren U, Gillstedt M, Trollfors B. Unexpected loss of contact allergy to aluminium induced by vaccine. Contact Dermatitis. 2013;68:286–92.

    Article  CAS  Google Scholar 

  14. Netterlid E, Bruze M, Hindsén M, Isaksson M, Olin P. Persisting itching nodules after the fourth dose of diphtheria-tetanus toxoid vaccines without evidence of delayed hypersensitivity to aluminium. Vaccine. 2004;22:3698–706.

    Article  CAS  Google Scholar 

  15. Brodbaker E, Pratt M. Contact sensitivity to aluminium. J Cutan Med Surg. 2009;13:226–9.

    Article  Google Scholar 

  16. Meding B, Augustsson A, Hansson C. Patch test reactions to aluminium. Contact Dermatitis. 1984;10:107.

    Article  CAS  Google Scholar 

  17. Garg S, Loghdey S, Gawkrodger DJ. Allergic contact dermatitis from aluminium in deodorants. Contact Dermatitis. 2010;62:57–8.

    Article  Google Scholar 

  18. O’Driscoll JB, Beck MB, Kesseler ME, Ford G. Contact sensitivity to aluminium acetate eardrops. Contact Dermatitis. 1991;24:156–7.

    Article  Google Scholar 

  19. Veien NK, Hattel T, Laurberg G. Systemic aggravated contact dermatitis caused by aluminium in toothpaste. Contact Dermatitis. 1993;28:199–200.

    Article  CAS  Google Scholar 

  20. McFadden N, Lyberg T, Hensten-Pettersen A. Aluminium-induced granulomas in tattoo. J Am Acad Dermatol. 1989;20:903–8.

    Article  CAS  Google Scholar 

  21. Peters T, Hani N, Kirchberg K, Gold H, Hunzelmann N, Scharffetter-Kochanek K. Occupational contact sensitivity to aluminium in a machine construction plant worker. Contact Dermatitis. 1998;39:322–3.

    Article  CAS  Google Scholar 

  22. Salik E, Lovik I, Andersen KE, Bygun A. Persistent skin reactions and aluminium hypersensitivity induced by childhood vaccines. Acta Derm Venereol. 2016;96:967–71.

    Article  CAS  Google Scholar 

  23. Bergfors E, Trollfors B, Inerot A, Gente Lidholm A. Contact allergy to aluminium induced by commonly used pediatric vaccines. Clin Transl Med. 2017;6:4.

    Article  CAS  Google Scholar 

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Correspondence to Monica Hindsén .

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Hindsén, M. (2018). Metal Allergy: Aluminium. In: Chen, J., Thyssen, J. (eds) Metal Allergy. Springer, Cham. https://doi.org/10.1007/978-3-319-58503-1_25

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  • DOI: https://doi.org/10.1007/978-3-319-58503-1_25

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  • Publisher Name: Springer, Cham

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