Abstract
Aluminium is one of the most abundant metals in the earth’s crust, and aluminium compounds are widely used. Aluminium is considered to be a weak allergen, but contact allergy to aluminium has been more frequently reported in recent years. The most important routes of sensitization to aluminium are aluminium-containing vaccines, hyposensitization with aluminium-adsorbed extracts and contact with aluminium in antiperspirants and other skin products. In this chapter, the literature on aluminium contact sensitization, patch testing and management considerations is reviewed.
References
Lidén C, Bruze M, Menné T. Metals. In: Menné T, Lepoittevin J-P, Frosch PJ, editors. Contact dermatitis. 4th ed. NewYork: Springer; 2006. p. 537–68.
Bergfors E, Trollfors B. Sixty-four children with persistent itching nodules and contact allergy to aluminium after vaccination with aluminium—absorbed vaccines-prognosis and outcome after booster vacccination. Eur J Pediatr. 2013;172(2):171–7.
Siemund I, Zimerson E, Hindsén M, Bruze M. Establishing aluminium contact allergy. Contact Dermatitis. 2012;67:162–70.
Clemmensen O, Knudsen HE. Contact sensitivity to aluminium in a patient hyposensitized with aluminium precipitated grass pollen. Contact Dermatitis. 1980;6:305–8.
Bruze M, Lundh K, Gruvberger B, Hindsén M. Aluminium chloride hexahydrat is insufficent to trace contact allergy to aluminium. Contact Dermatitis. 2008;59:183–4.
Frost L, Johansen P, Pedersen S, Veien N, Ostergaard PA, Nielsen MH. Persistent subcutaneous nodules in children hyposensitized with aluminium-containing allergen extracts. Allergy. 1985;40:368–72.
Lopez S, Pelaez A, Navorro A, Montesinos E, Morales C, Carda C. Aluminium allergy in patient hyposensitized with aluminium-precipitated antigen extracts. Contact Dermatitis. 1994;31:37–40.
Hindsén M. Contact allergy to aluminium in patients hyposensitized with aluminium-containing hyposensitizing extracts. Contact Dermatitis. 2005;53:301–2.
Netterlid E, Hindsén M, Björk J, Ekqvist S, Guner N, Henriksson KÅ, Bruze M. There is an association between contact allergy to aluminium and persistent sucutaneous nodules in children undergoing hypersensitization therapy. Contact Dermatitis. 2009;60:41–9.
Netterlid E, Hindsén M, Siemund I, Björk J, Werner S, Jacobsson H, Guner N, Bruze M. Does allergen-specific immunotherapy induce contact allergy to aluminium? Acta Derm Venereol. 2013;93:50–6.
Bergfors E, Trollfors B, Inerot A. Uexpected high incidence of persistent iching nodules and delayed hypersensitivityto aluminiumin children after the use of absorbed vaccines from a single manufacturen. Vaccine. 2003;22:64–9.
Siemund I, Hindsén M, Zimerson E, Bruze M. Individual variation in aluminium patch test reactivity. Abstract ESCD Manchester. 2016.
Lidholm AG, Bergfors E, Inerot A, Blomgren U, Gillstedt M, Trollfors B. Unexpected loss of contact allergy to aluminium induced by vaccine. Contact Dermatitis. 2013;68:286–92.
Netterlid E, Bruze M, Hindsén M, Isaksson M, Olin P. Persisting itching nodules after the fourth dose of diphtheria-tetanus toxoid vaccines without evidence of delayed hypersensitivity to aluminium. Vaccine. 2004;22:3698–706.
Brodbaker E, Pratt M. Contact sensitivity to aluminium. J Cutan Med Surg. 2009;13:226–9.
Meding B, Augustsson A, Hansson C. Patch test reactions to aluminium. Contact Dermatitis. 1984;10:107.
Garg S, Loghdey S, Gawkrodger DJ. Allergic contact dermatitis from aluminium in deodorants. Contact Dermatitis. 2010;62:57–8.
O’Driscoll JB, Beck MB, Kesseler ME, Ford G. Contact sensitivity to aluminium acetate eardrops. Contact Dermatitis. 1991;24:156–7.
Veien NK, Hattel T, Laurberg G. Systemic aggravated contact dermatitis caused by aluminium in toothpaste. Contact Dermatitis. 1993;28:199–200.
McFadden N, Lyberg T, Hensten-Pettersen A. Aluminium-induced granulomas in tattoo. J Am Acad Dermatol. 1989;20:903–8.
Peters T, Hani N, Kirchberg K, Gold H, Hunzelmann N, Scharffetter-Kochanek K. Occupational contact sensitivity to aluminium in a machine construction plant worker. Contact Dermatitis. 1998;39:322–3.
Salik E, Lovik I, Andersen KE, Bygun A. Persistent skin reactions and aluminium hypersensitivity induced by childhood vaccines. Acta Derm Venereol. 2016;96:967–71.
Bergfors E, Trollfors B, Inerot A, Gente Lidholm A. Contact allergy to aluminium induced by commonly used pediatric vaccines. Clin Transl Med. 2017;6:4.
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Hindsén, M. (2018). Metal Allergy: Aluminium. In: Chen, J., Thyssen, J. (eds) Metal Allergy. Springer, Cham. https://doi.org/10.1007/978-3-319-58503-1_25
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