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Stress and Glucocorticoid Action in the Brain and Ear: Implications for Tinnitus

  • E. R. de Kloet
  • Agnieszka J. SzczepekEmail author
Chapter

Abstract

This contribution highlights the role of stress and cortisol in tinnitus. Firstly, stressors such as loud noise, infection, and injury can cause hearing loss and tinnitus pathology. Secondly, stress-induced cortisol levels are decreased in individuals with tinnitus with consequences for functioning of the inner ear, the central auditory system, and its targets in the limbic brain circuit relevant for processing of stressful acoustic information. Thirdly, the phantom sound experienced by the tinnitus patient eventually may precipitate signs of a stress-related disorder. The chapter concludes with options to exploit cortisol action for tinnitus management.

Keywords

Tinnitus Stress Brain Corticosteroids Mineralocorticoid receptors Glucocorticoid receptors 

Notes

Acknowledgment

The support to ER de Kloet by the Royal Netherlands Academy of Arts and Sciences, COST Action ADMIRE BM1301 and STW Take-off 14095 is gratefully acknowledged.

AJ Szczepek thankfully acknowledges the research support of Dürr Foundation and the German Tinnitus Foundation.

Declaration of Interest

E R. de Kloet is on the scientific advisory Board of Dynacorts Therapeutics and Pharmaseed Ltd. and owns stock of Corcept Therapeutics. The current paper bears no relationship to these interests.

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Division of Endocrinology, Department of Internal MedicineLeiden University Medical CenterLeidenThe Netherlands
  2. 2.Department of Otorhinolaryngology, Head and Neck SurgeryCharité University HospitalBerlinGermany

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