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Comparative Aspects of CgA-Derived Peptides in Cardiac Homeostasis

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Chromogranins: from Cell Biology to Physiology and Biomedicine

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Abstract

This chapter is an overview of the cardiotropic actions of the Chromogranin A-derived peptides, vasostatins and catestatin on the isolated and perfused eel (Anguilla anguilla) and frog (Rana esculenta) hearts, used as paradigms of fish and amphibian hearts. Our studies highlight important cardiotropic features of the two peptides both at basal (negative inotropism) and stimulated (anti-adrenergic effect: eel and frog; anti-endothelin action: frog) conditions. In addition, catestatin positively modulates the Frank-Starling response both in eel and frog hearts. Overall, the comparison of vasostatins and catestatin-mediated role in cardiac homeostasis of fish and amphibians illustrates aspects of uniformity and species specific differences in the mechanism of action of the peptides.

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Abbreviations

Akt:

Protein kinase B

ANP:

Atrial natriuretic peptide

bCgA4–16:

bovine CgA4–16

bCgA47–66:

bovine CgA47–66

CA:

Catecholamines

CgA:

Chromogranin A

CgA1–40SH:

CgA1–40 without an intact disulfide bridge

CgA1–40SS:

CgA1–40 with an intact disulfide bridge

CST:

Catestatin

EE:

Endocardial endothelium

eNOS:

Endothelial nitric oxide synthase

ET-1:

Endothelin-1

ETAR:

Endothelin-1 A subtype receptor

ETBR:

Endothelin-1 B subtype receptor

fCgA4–16:

frog CgA4–16

fCgA47–66:

frog CgA47–66

ISO:

Isoproterenol

NO:

Nitric Oxide

NOS:

Nitric Oxide Synthase

PI3K:

Phosphatidyl 3-kinase

PKG:

Protein Kinase G

PLN:

Phospholamban

PTx:

Pertussis toxin

SERCA2a:

Sarcoplasmic Reticulum Ca2+−ATPase

VS-1:

Vasostatin 1 (CgA1–76)

VS-2:

Vasostatin 2 (CgA1–113)

VSs:

Vasostatins

W7:

N-(6-aminohexil)-5-chloro-1-naphthalenesulfonamide

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Authors and Affiliations

  1. Department of Biology, Ecology, and Earth Science, University of Calabria, 87036, Arcavacata di Rende, Italy

    Alfonsina Gattuso PhD, Sandra Imbrogno & Rosa Mazza

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  1. Alfonsina Gattuso PhD
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  2. Sandra Imbrogno
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  3. Rosa Mazza
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Correspondence to Alfonsina Gattuso PhD .

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Editors and Affiliations

  1. Department of Biology, Ecology and Earth Sciences, University of Calabria, Arcavacata di Rende, Cosenza, Italy

    Tommaso Angelone

  2. Department of Biology, Ecology and Earth Sciences, University of Calabria, Arcavacata di Rende, Cosenza, Italy

    Maria Carmela Cerra

  3. Department of Biology, Ecology and Earth Science, University of Calabria, Arcavacata di Rende, Cosenza, Italy

    Bruno Tota

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Gattuso, A., Imbrogno, S., Mazza, R. (2017). Comparative Aspects of CgA-Derived Peptides in Cardiac Homeostasis. In: Angelone, T., Cerra, M., Tota, B. (eds) Chromogranins: from Cell Biology to Physiology and Biomedicine. UNIPA Springer Series. Springer, Cham. https://doi.org/10.1007/978-3-319-58338-9_9

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