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Secretogranin II: Novel Insights into Expression and Function of the Precursor of the Neuropeptide Secretoneurin

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Chromogranins: from Cell Biology to Physiology and Biomedicine

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Abstract

SgII is an acidic secretory which belongs to the family of chromogranins. It is present in the large-dense cored vesicles of the regulated secretory pathway of many neurons and endocrine cells and it is well conserved during evolution. Like chromogranin A, SgII can induce granulogenesis in endocrine cells but also in cells typically lacking secretory vesicles like fibroblasts. In the secretory vesicles SgII is processed to smaller peptides, e.g. secretoeneurin, EM66 and manserin. For secretoneurin several biological effects like induction of neurotransmitter release, chemotactic activity towards immune-, endothelial- and muscle cells, and potent angiogenic and vasculogenic properties have been established. Thus, SN displays potent hormonal and paracrine effects, which help to orchestrate development, maintenance, physiologic activity and repair of the surrounding tissue. In addition, SgII has been established as valuable biomarker for endocrine tumours and cardiovascular diseases.

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Authors and Affiliations

  1. Department of Pharmacology, Medical University Innsbruck, Peter Mayr Str. 1a, A-6020, Innsbruck, Austria

    Reiner Fischer-Colbrie PhD

  2. Cardiology & Angiology, Internal Medicine III, Medical University Innsbruck, Innsbruck, Austria

    Markus Theurl & Rudolf Kirchmair

Authors
  1. Reiner Fischer-Colbrie PhD
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  2. Markus Theurl
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  3. Rudolf Kirchmair
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Correspondence to Reiner Fischer-Colbrie PhD .

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Editors and Affiliations

  1. Department of Biology, Ecology and Earth Sciences, University of Calabria, Arcavacata di Rende, Cosenza, Italy

    Tommaso Angelone

  2. Department of Biology, Ecology and Earth Sciences, University of Calabria, Arcavacata di Rende, Cosenza, Italy

    Maria Carmela Cerra

  3. Department of Biology, Ecology and Earth Science, University of Calabria, Arcavacata di Rende, Cosenza, Italy

    Bruno Tota

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Fischer-Colbrie, R., Theurl, M., Kirchmair, R. (2017). Secretogranin II: Novel Insights into Expression and Function of the Precursor of the Neuropeptide Secretoneurin. In: Angelone, T., Cerra, M., Tota, B. (eds) Chromogranins: from Cell Biology to Physiology and Biomedicine. UNIPA Springer Series. Springer, Cham. https://doi.org/10.1007/978-3-319-58338-9_2

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