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Protein Deimination in Human Health and Disease pp 161–172Cite as

Citrullination and Autophagy

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Abstract

During evolution, the eukaryotic cells develop different processes in order to adapt themselves to environmental changes, as well as to die or to survive. These processes include apoptosis, NETosis, and autophagy: citrullination is implicated in all of these physiological mechanisms.

Autophagy plays a crucial role in physiology and pathophysiology, such as aging, infectious diseases, cancer, and perturbations in autophagy have also been implicated in autoimmune diseases.

It was demonstrated that autophagy was involved in the generation of citrullinated peptides by antigen presenting cells (APCs), with increased peptidyl arginine deiminase activity detected in purified autophagosomes.

Self-peptides posttranslationally modified by a process such as citrullination would possibly form neo-antigens that are recognized by APCs of the immune system and thus represent a target for autoimmunity.

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Author information

Authors and Affiliations

  1. Rheumatology, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy

    Guido Valesini, Tania Colasanti, Cristiano Alessandri & Fabrizio Conti

  2. Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, UK

    Michele Bombardieri

  3. Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

    Maurizio Sorice

Authors
  1. Guido Valesini
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  2. Tania Colasanti
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  3. Cristiano Alessandri
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  4. Michele Bombardieri
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  5. Fabrizio Conti
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  6. Maurizio Sorice
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Corresponding author

Correspondence to Guido Valesini .

Editor information

Editors and Affiliations

  1. Department of Neurology, University of Alabama at Birmingham and The Birmingham Veterans Administration Medical Center, Birmingham, Alabama, USA

    Anthony P. Nicholas

  2. Bascom Palmer Eye Institute, University of Miami, Miami, Florida, USA

    Sanjoy K. Bhattacharya

  3. Department of Biochemistry and Molecular Pharmacology, UMASS Medical School, Worcester, Massachusetts, USA

    Paul R. Thompson

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Valesini, G., Colasanti, T., Alessandri, C., Bombardieri, M., Conti, F., Sorice, M. (2017). Citrullination and Autophagy. In: Nicholas, A., Bhattacharya, S., Thompson, P. (eds) Protein Deimination in Human Health and Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-58244-3_9

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