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Optical Coherence Tomography: A Review

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Interventions in Pulmonary Medicine

Abstract

Optical coherence tomography (OCT), with polarization-sensitive (PS), Doppler, and autofluorescence (AF) capabilities, is emerging as a promising bronchoscopic diagnostic tool. In the upper and central airways, it allows accurate real-time airway measurements to assist bronchoscopic assessment of obstructive sleep apnea, severity of tracheomalacia, airway stenosis, or extent of tumor involvement into the bronchial wall or distally beyond the bronchoscopic view. OCT can visualize cellular and extracellular structures at and below the tissue surface with near histologic resolution as well as to provide three-dimensional imaging of the airways. Blood vessels in the bronchial wall or peribronchial space can be displayed using Doppler OCT or AF-OCT. Biochemical information can be extracted using PS-OCT and AF-OCT. With miniaturized imaging probes, the entire airway can be evaluated down to the terminal bronchioles and adjacent lung parenchyma for diagnosis and evaluation of therapeutic interventions in both malignant and nonmalignant diseases.

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Authors and Affiliations

  1. Cancer Imaging Unit, Integrative Oncology Department, British Columbia Cancer Agency Research Centre, 675 West 10th Avenue, Vancouver, BC, Canada, V5Z 1L3

    Tawimas Shaipanich MD, FRCPC, Hamid Pahlevaninezhad MD, PhD & Stephen Lam MD, FRCPC

  2. The University of British Columbia, Vancouver, BC, Canada

    Tawimas Shaipanich MD, FRCPC, Hamid Pahlevaninezhad MD, PhD & Stephen Lam MD, FRCPC

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  1. Tawimas Shaipanich MD, FRCPC
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  2. Hamid Pahlevaninezhad MD, PhD
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  3. Stephen Lam MD, FRCPC
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Correspondence to Stephen Lam MD, FRCPC .

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Editors and Affiliations

  1. Clínica Corachan and Bellvitge, University Hospital, Barcelona, Spain

    Jose Pablo Díaz-Jimenez

  2. Pulmonary Department, Clinica y Maternidad Colon, Pulmonary Research Department, IIC Mar del Plata, Buenos Aires, Argentina

    Alicia N. Rodriguez

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Shaipanich, T., Pahlevaninezhad, H., Lam, S. (2018). Optical Coherence Tomography: A Review. In: Díaz-Jimenez, J., Rodriguez, A. (eds) Interventions in Pulmonary Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-58036-4_16

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