Abstract
Surgery still remains the cornerstone of breast cancer treatment but in some cases it has been implicated for stimulating early locoregional recurrence or even distant metastatic spread. There is evidence that angiogenesis, initiated by the surgical wounding itself during the process of healing, could offer valuable answers in such matters as well as enable a more profound understanding of the mechanisms of carcinogenesis in general. In our study, we investigated the impact of breast surgery on circulating angiogenesis-related factors in the peripheral blood. We used plasma samples from ten female patients with biopsy-proven breast cancer (Ca group) and six other females with fibroadenoma (Control group) before surgery (PRO) and post-operatively on days 3 (D3) and 7 (D7, only for breast cancer patients). These samples were analyzed for circulating levels of vascular endothelial growth factor A (VEGF-A), Interleukin-8 (IL-8) and fibroblast growth factor 2 (FGF2/bFGF) using ELISA. Moreover, 84 angiogenesis-associated mRNA transcripts were also assessed using quantitative RT-PCR arrays at the same time points. We were able to find a different angiogenic profile between breast cancer patients and those with benign breast disease (fibroadenoma). The effect of surgery on the mechanism of new blood vessel formation was found to be more robust and far more prolonged in women suffering from malignancy of the breast, than those operated for fibroadenoma. Mastectomy provoked a transient increase in VEGF-A plasma levels and altered the expression of many angiogenesis-related circulating gene transcripts.
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Georgiou, G.K., Briasoulis, E. (2017). Peri-operative Shift in Angiogenesis-Related Factors in Breast Cancer Patients. In: Retsky, M., Demicheli, R. (eds) Perioperative Inflammation as Triggering Origin of Metastasis Development. Springer, Cham. https://doi.org/10.1007/978-3-319-57943-6_3
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