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The Systemic Effects of Local Treatments (Surgery and Radiotherapy) of Breast Cancer

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Perioperative Inflammation as Triggering Origin of Metastasis Development

Abstract

In general, treatment of solid tumours has been compartmentalized as local treatment and systemic treatment. The only systemic oncological effect of local treatment is supposedly eradication of the primary cancer thereby reducing the probability of further systemic spread. However, as will be described here there are instances where local treatment could impact the outcome in diverse ways. We describe how the modulation of surgery by changing its extent or addition of intraoperative radiation appears greatly impact it systemic effects.

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Author information

Authors and Affiliations

  1. Division of Surgery and Interventional Science, University College London, London, UK

    Jayant S. Vaidya MBBS, MS, DNB, FRCS, PhD (Professor of Surgery and Oncology, Consultant Surgeon)

  2. Whittington Health, Royal Free Hospital and University College London Hospital, London, UK

    Jayant S. Vaidya MBBS, MS, DNB, FRCS, PhD (Professor of Surgery and Oncology, Consultant Surgeon)

Authors
  1. Jayant S. Vaidya MBBS, MS, DNB, FRCS, PhD
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Corresponding author

Correspondence to Jayant S. Vaidya MBBS, MS, DNB, FRCS, PhD .

Editor information

Editors and Affiliations

  1. Harvard TH Chan School of Public Health, Boston, Massachusetts, USA

    Michael W. Retsky

  2. Istituto Nazionale Tumori di Milano, Fondazione IRCCS, Milan, Italy

    Romano Demicheli

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Vaidya, J.S. (2017). The Systemic Effects of Local Treatments (Surgery and Radiotherapy) of Breast Cancer. In: Retsky, M., Demicheli, R. (eds) Perioperative Inflammation as Triggering Origin of Metastasis Development. Springer, Cham. https://doi.org/10.1007/978-3-319-57943-6_11

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