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STIM-TRP Pathways and Microdomain Organization: Ca2+ Influx Channels: The Orai-STIM1-TRPC Complexes

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Store-Operated Ca²⁺ Entry (SOCE) Pathways

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 993))

Abstract

Ca2+ influx by plasma membrane Ca2+ channels is the crucial component of the receptor-evoked Ca2+ signal. The two main Ca2+ influx channels of non-excitable cells are the Orai and TRPC families of Ca2+ channels. These channels are activated in response to cell stimulation and Ca2+ release from the endoplasmic reticulum (ER). The protein that conveys the Ca2+ content of the ER to the plasma membrane is the ER Ca2+ sensor STIM1. STIM1 activates the Orai channels and is obligatory for channel opening. TRPC channels can function in two modes, as STIM1-dependent and STIM1-independent. When activated by STIM1, both channel types function at the ER/PM (plasma membrane) junctions. This chapter describes the properties and regulation of the channels by STIM1, with emphasis how and when TRPC channels function as STIM1-dependent and STIM1-independent modes and their unique Ca2+-dependent physiological functions that are not shared with the Orai channels.

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Authors and Affiliations

  1. Epithelial Signaling and Transport Section, National Institute of Dental and Craniofacial Research – NIDCR, National Institute of Health, Building 10, Room 1N-112, Bethesda, MD, 20892, USA

    Dora Bodnar, Woo Young Chung, Archana Jha & Shmuel Muallem

  2. Department of Physiology, Collage of Medicine, Gachon University, 155 Gaetbeol-ro, Yeonsu-gu, Incheon City, 21999, Korea

    Dongki Yang & Jeong Hee Hong

Authors
  1. Dora Bodnar
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  2. Woo Young Chung
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  3. Dongki Yang
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  4. Jeong Hee Hong
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  5. Archana Jha
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  6. Shmuel Muallem
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Correspondence to Shmuel Muallem .

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Editors and Affiliations

  1. Institute of Biophysics, Medical University of Graz, Graz, Austria

    Klaus Groschner

  2. Institute of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria

    Wolfgang F. Graier

  3. Institute of Biophysics, Johannes Kepler University Linz, Linz, Austria

    Christoph Romanin

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Bodnar, D., Chung, W.Y., Yang, D., Hong, J.H., Jha, A., Muallem, S. (2017). STIM-TRP Pathways and Microdomain Organization: Ca2+ Influx Channels: The Orai-STIM1-TRPC Complexes. In: Groschner, K., Graier, W., Romanin, C. (eds) Store-Operated Ca²⁺ Entry (SOCE) Pathways. Advances in Experimental Medicine and Biology, vol 993. Springer, Cham. https://doi.org/10.1007/978-3-319-57732-6_8

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