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The STIM-Orai Pathway: The Interactions Between STIM and Orai

  • Marc FahrnerEmail author
  • Rainer Schindl
  • Martin Muik
  • Isabella Derler
  • Christoph RomaninEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 993)

Abstract

A primary Ca2+ entry pathway in non-excitable cells is established by the Ca2+ release-activated Ca2+ channels. Their two limiting molecular components include the Ca2+-sensor protein STIM1 located in the endoplasmic reticulum and the Orai channel in the plasma membrane. STIM1 senses the luminal Ca2+ content, and store depletion induces its oligomerization into puncta-like structures, thereby triggering coupling to as well as activation of Orai channels. A C-terminal STIM1 domain is assumed to couple to both C- and N-terminal, cytosolic strands of Orai, accomplishing gating of the channel. Here we highlight the inter- and intramolecular steps of the STIM1-Orai signaling cascade together with critical sites of the pore structure that accomplishes Ca2+ permeation.

Keywords

STIM-Orai coupling STIM oligomerization Orai nexus Orai activation Orai pore 

Notes

Acknowledgments

This work was supported by the Austrian Science Fund projects P28123 (to MF), P26067 (to RS), P28498 (to MM), P25210 as well as P27641 (to ID), and P27263 (to CR).

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Institute of BiophysicsJohannes Kepler University LinzLinzAustria

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