The STIM-Orai Pathway: Orai, the Pore-Forming Subunit of the CRAC Channel

  • Aparna GudlurEmail author
  • Patrick G. HoganEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 993)


This chapter focuses on the Orai proteins, Orai1–Orai3, with special emphasis on Orai1, in humans and other mammals, and on the definitive evidence that Orai is the pore subunit of the CRAC channel. It begins by reviewing briefly the defining characteristics of the CRAC channel, then discusses the studies that implicated Orai as part of the store-operated Ca2+ entry pathway and as the CRAC channel pore subunit, and finally examines ongoing work that is providing insights into CRAC channel structure and gating.


Orai1 STIM1 Calcium channel Calcium conductance CRAC channel CRAC current Gating 



The authors’ work on STIM-Orai signaling is funded by US National Institutes of Health grants AI084167 and GM110397.


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© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Division of Signalling and Gene ExpressionLa Jolla Institute for Allergy and ImmunologyLa JollaUSA

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