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Immunological Disorders: Regulation of Ca2+ Signaling in T Lymphocytes

  • Sonal Srikanth
  • Jin Seok Woo
  • Zuoming Sun
  • Yousang GwackEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 993)

Abstract

Engagement of T cell receptors (TCRs) with cognate antigens triggers cascades of signaling pathways in helper T cells. TCR signaling is essential for the effector function of helper T cells including proliferation, differentiation, and cytokine production. It also modulates effector T cell fate by inducing cell death, anergy (nonresponsiveness), exhaustion, and generation of regulatory T cells. One of the main axes of TCR signaling is the Ca2+-calcineurin-nuclear factor of activated T cells (NFAT) signaling pathway. Stimulation of TCRs triggers depletion of intracellular Ca2+ store and, in turn, activates store-operated Ca2+ entry (SOCE) to raise the intracellular Ca2+ concentration. SOCE in T cells is mediated by the Ca2+ release-activated Ca2+ (CRAC) channels, which have been very well characterized in terms of their electrophysiological properties. Identification of STIM1 as a sensor to detect depletion of the endoplasmic reticulum (ER) Ca2+ store and Orai1 as the pore subunit of CRAC channels has dramatically advanced our understanding of the regulatory mechanism of Ca2+ signaling in T cells. In this review, we discuss our current understanding of Ca2+ signaling in T cells with specific focus on the mechanism of CRAC channel activation and regulation via protein interactions. In addition, we will discuss the role of CRAC channels in effector T cells, based on the analyses of genetically modified animal models.

Keywords

T-cell receptor signaling CRAC channels Orai and STIM proteins Effector T cells Cytokine production Differentiation of T cells 

Notes

Acknowledgments

This work was supported by National Institute of Health grants AI-083432 and AI109059 (Y.G.).

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Sonal Srikanth
    • 1
  • Jin Seok Woo
    • 1
  • Zuoming Sun
    • 2
  • Yousang Gwack
    • 1
    Email author
  1. 1.Department of PhysiologyDavid Geffen School of Medicine at UCLALos AngelesUSA
  2. 2.Department of Molecular Immunology, Beckman Research InstituteCity of HopeDuarteUSA

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