Introduction: Overview of the Pathophysiological Implications of Store-Operated Calcium Entry in Mammalian Cells

  • Juan A. RosadoEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 993)


Since store-operated Ca2+ entry (SOCE) was proposed by Putney three decades ago (Putney. Cell Calcium 7:1–12, 1986), its functional role and involvement in the pathophysiology of a number of disorders has been investigated. The role of SOCE in cell physiology has been discussed in the previous chapters, and the following part is devoted to the current knowledge concerning the mechanisms underlying the development of certain diseases that involve SOCE abnormalities.


Orai1 STIM1 SOCE SCID Stormorken syndrome York platelet syndrome 


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Cell Physiology Research Group, Department of PhysiologyUniversity of ExtremaduraCáceresSpain

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