Hemoglobinopathies in Pregnancy

  • Kate C. Arnold
  • Caroline J. Flint


Adult hemoglobin is composed of two alpha and two beta chains. Hemoglobinopathies result when there is an alteration in these chains. The two most salient diagnoses are the thalassemias and sickle cell disease. Pregnant patients with sickle cell disease are at high risk for poor outcomes and should have antenatal surveillance [1].


Hemoglobinopathy Anemia Sickle cell disease Thalassemia 


  1. 1.
    Gabbe SG, Niebyl JR, Simpson JL, Landon MB, Galan HL, Jauniaux ERM, Driscoll DA. Obstetrics: normal and problem pregnancies. Chapter 42. 6th ed. Philadelphia, PA: Elsevier; 2012.Google Scholar
  2. 2.
    American College of Obstetricians and Gynecologists. ACOG practice bulletin no. 78: hemoglobinopathies in pregnancy. Obstet Gynecol. 2007;109:229–37.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Kate C. Arnold
    • 1
  • Caroline J. Flint
    • 1
  1. 1.Department of OB/GYNUniversity of Oklahoma HSCOklahoma CityUSA

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