Management of Alloimmunization During Pregnancy

  • Kate C. Arnold
  • Caroline J. Flint


Once alloimmunization is diagnosed during pregnancy, maternal titers must be followed unless it is known that the father is also Rh negative. Maternal levels should be followed until a critical titer is reached, after which MCA Doppler studies should be performed. In severe cases, intrauterine transfusion may be needed [1].


Alloimmunization Critical titer Middle cerebral Doppler Kell Rh negative 


  1. 1.
    Gabbe SG, Niebyl JR, Simpson JL, Landon MB, Galan HL, Jauniaux ERM, Driscoll DA. Obstetrics: normal and problem pregnancies. Chapter 32. 6th ed. Philadelphia, PA: Elsevier; 2012.Google Scholar
  2. 2.
    American College of Obstetricians and Gynecologists. ACOG practice bulletin no. 75: management of alloimmunization during pregnancy. Obstet Gynecol. 2006;108:457–64.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Kate C. Arnold
    • 1
  • Caroline J. Flint
    • 1
  1. 1.Department of OB/GYNUniversity of Oklahoma HSCOklahoma CityUSA

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