Pregestational Diabetes Mellitus

  • Kate C. Arnold
  • Caroline J. Flint


Diabetes mellitus is a metabolic disorder. Type 1 diabetes is caused by autoimmune destruction of the pancreas, making patients dependent on exogenous insulin; during pregnancy these patients are at increased risk for diabetic ketoacidosis and hypoglycemia. Type 2 diabetes is caused by decreased insulin sensitivity and often they can be managed with oral agents; these patients are generally older and more likely to be obese. Pregnancy outcomes for women with pregestational diabetes are improved with glucose monitoring and control [1].


Diabetes mellitus Diabetic ketoacidosis Insulin Hypoglycemia 


  1. 1.
    Gabbe SG, Niebyl JR, Simpson JL, Landon MB, Galan HL, Jauniaux ERM, Driscoll DA. Obstetrics: normal and problem pregnancies. Chapter 39. 6th ed. Philadelphia, PA: Elsevier; 2012.Google Scholar
  2. 2.
    American College of Obstetricians and Gynecologists. ACOG practice bulletin no. 60: pregestational diabetes mellitus. Obstet Gynecol. 2005;105:675–85.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Kate C. Arnold
    • 1
  • Caroline J. Flint
    • 1
  1. 1.Department of OB/GYNUniversity of Oklahoma HSCOklahoma CityUSA

Personalised recommendations