Abstract
Neural tube defects include spina bifida and anencephaly. They are associated with maternal diabetes and use of antiepileptic drugs as well as a history of a previous pregnancy with a neural tube defect. The defects are often due to low levels of folate at the time of neural tube closure, which is why recommended folate supplementation should begin prior to conception [1].
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Gabbe SG, Niebyl JR, Simpson JL, Landon MB, Galan HL, Jauniaux ERM, Driscoll DA. Obstetrics: normal and problem pregnancies. Chapter 7. 6th ed. Philadelphia, PA: Elsevier; 2012.
American College of Obstetricians and Gynecologists. ACOG practice bulletin no. 44: neural tube defects. Obstet Gynecol. 2003;102:203–13.
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Arnold, K.C., Flint, C.J. (2017). Neural Tube Defects. In: Obstetrics Essentials. Springer, Cham. https://doi.org/10.1007/978-3-319-57675-6_4
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DOI: https://doi.org/10.1007/978-3-319-57675-6_4
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