Neural tube defects include spina bifida and anencephaly. They are associated with maternal diabetes and use of antiepileptic drugs as well as a history of a previous pregnancy with a neural tube defect. The defects are often due to low levels of folate at the time of neural tube closure, which is why recommended folate supplementation should begin prior to conception .
KeywordsNeural tube Spina bifida Maternal serum alpha-fetoprotein Folic acid
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