Thyroid Disease in Pregnancy
Pregnancy results in increased thyroxine-binding globulin and increased thyroid-stimulating hormone receptor activation due to human chorionic gonadotropin. This results in increased secretion of thyroid hormones. In hyperthyroidism patients, propylthiouracil and methimazole are the drugs of choice depending on fetal gestational age. More than half of patients with hypothyroidism will need to increase the dose of their replacement during pregnancy. Thyroid storm is rare but life-threatening and should be managed in an intensive care unit .
KeywordsGraves Hyperthyroid Hypothyroid PTU Methimazole Thyroid storm TSH
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