Thyroid Disease in Pregnancy

  • Kate C. Arnold
  • Caroline J. Flint


Pregnancy results in increased thyroxine-binding globulin and increased thyroid-stimulating hormone receptor activation due to human chorionic gonadotropin. This results in increased secretion of thyroid hormones. In hyperthyroidism patients, propylthiouracil and methimazole are the drugs of choice depending on fetal gestational age. More than half of patients with hypothyroidism will need to increase the dose of their replacement during pregnancy. Thyroid storm is rare but life-threatening and should be managed in an intensive care unit [1].


Graves Hyperthyroid Hypothyroid PTU Methimazole Thyroid storm TSH 


  1. 1.
    Gabbe SG, Niebyl JR, Simpson JL, Landon MB, Galan HL, Jauniaux ERM, Driscoll DA. Obstetrics: normal and problem pregnancies. Chapter 40. 6th ed. Philadelphia, PA: Elsevier; 2012.Google Scholar
  2. 2.
    American College of Obstetricians and Gynecologists. Practice bulletin no. 148: thyroid disease in pregnancy. Obstet Gynecol. 2015;125:996–1005.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Kate C. Arnold
    • 1
  • Caroline J. Flint
    • 1
  1. 1.Department of OB/GYNUniversity of Oklahoma HSCOklahoma CityUSA

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