Prevention of Rh D Alloimmunization

  • Kate C. Arnold
  • Caroline J. Flint


Red cell alloimmunization refers to the production of maternal anti-red cell antibodies which can lead to fetal effects ranging from anemia to hydrops. With the use of anti-D immune globulin the incidence of red cell alloimmunization has decreased significantly. There are guidelines regarding prevention and management of pregnancies affected by the disease [1].


Alloimmunization Anemia Anti-D immune globulin Rh negative 


  1. 1.
    Gabbe SG, Niebyl JR, Simpson JL, Landon MB, Galan HL, Jauniaux ERM, Driscoll DA. Obstetrics: normal and problem pregnancies. 6th ed. Philadelphia, PA: Elsevier; 2012.Google Scholar
  2. 2.
    American College of Obstetricians and Gynecologists. Practice bulletin no. 4: prevention of Rh D alloimmunization. Obstet Gynecol. 2016:1099–3630.Google Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Kate C. Arnold
    • 1
  • Caroline J. Flint
    • 1
  1. 1.Department of OB/GYNUniversity of Oklahoma HSCOklahoma CityUSA

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