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The Immunology of Cardiovascular Homeostasis and Pathology pp 145–171Cite as

Immune-Mediated Heart Disease

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1003))

Abstract

The heart involvement in systemic autoimmune diseases represents a growing burden for patients and health systems. Cardiac function can be impaired as a consequence of systemic conditions and manifests with threatening clinical pictures or chronic myocardial damage. Direct injuries are mediated by the presence of inflammatory infiltrate which, even though unusual, is one of the most danger manifestations requiring prompt recognition and treatment. On the other hand, a not well-managed inflammatory status leads to accelerated atherosclerosis that precipitates ischemic disease. All cardiac structures may be damaged with different grades of intensity; moreover, lesions can appear simultaneously or more frequently at a short distance from each other leading to the onset of varied clinical pictures. The pathogenesis of heart damages in systemic autoimmune conditions is not yet completely understood for the great part of situations, even if several mechanisms have been investigated. The principal biochemical circuits refer to the damaging role of autoantibodies on cardiac tissues and the precipitation of immune complexes on endocardium. These events are finally responsible of inflammatory infiltration which leads to subsequent worsening of the previous damage. For these reasons, it appears of paramount importance a regular and deepened cardiovascular assessment to prevent a progressive evolution toward heart failure in patient affected by autoimmune diseases.

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Authors and Affiliations

  1. Rheumatology and Clinical Immunology, Humanitas Research Hospital, Rozzano, Milan, Italy

    Elena Generali & Carlo Selmi

  2. Allergy, Clinical Immunology and Rheumatology Unit, IRCCS Istituto Auxologico Italiano, Milan, Italy

    Marco Folci & Piersandro Riboldi

  3. BIOMETRA Department, University of Milan, Milan, Italy

    Carlo Selmi

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  1. Elena Generali
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  2. Marco Folci
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  3. Carlo Selmi
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  4. Piersandro Riboldi
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Correspondence to Piersandro Riboldi .

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  1. Hammersmith Campus, Imperial College London National Heart and Lung Institute, London, United Kingdom

    Susanne Sattler

  2. Hammersmith Campus, Imperial College London National Heart and Lung Institute, London, United Kingdom

    Teresa Kennedy-Lydon

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Generali, E., Folci, M., Selmi, C., Riboldi, P. (2017). Immune-Mediated Heart Disease. In: Sattler, S., Kennedy-Lydon, T. (eds) The Immunology of Cardiovascular Homeostasis and Pathology. Advances in Experimental Medicine and Biology, vol 1003. Springer, Cham. https://doi.org/10.1007/978-3-319-57613-8_8

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