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Lymphocytes at the Heart of Wound Healing

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The Immunology of Cardiovascular Homeostasis and Pathology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1003))

Abstract

The adult mammalian heart displays negligible regenerative capacity. Therefore, myocardial infarction (MI) often results in an irreversible loss of contractile tissue, leading to a collagenous scar formation, progressive remodelling and heart failure (HF). Over the past few years, emerging evidences indicate that a myocardial ischemic injury mobilizes not only sterile unspecific inflammation but also lymphocyte-mediated immune responses to cardiac auto-antigens. In the current chapter, we depict the infarcted heart as a “wounded” tissue and focus on the dynamic events leading to myocardial repair, with special emphasis on the role played by lymphocytes in this process.

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Authors and Affiliations

  1. Instituto Gulbenkian de Ciência, PT-2781-901, Oeiras, Portugal

    Vânia Nunes-Silva

  2. Department of Internal Medicine III, University Clinic Halle, 06120, Halle, Germany

    Stefan Frantz & Gustavo Campos Ramos

  3. Martin-Luther-Universität Halle-Wittenberg Universitätsklinik und Poliklinik für Innere Medizin III, Ernst-Grube-Str. 40, 06120, Halle, Germany

    Gustavo Campos Ramos

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  1. Vânia Nunes-Silva
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  2. Stefan Frantz
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  3. Gustavo Campos Ramos
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Correspondence to Gustavo Campos Ramos .

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  1. Hammersmith Campus, Imperial College London National Heart and Lung Institute, London, United Kingdom

    Susanne Sattler

  2. Hammersmith Campus, Imperial College London National Heart and Lung Institute, London, United Kingdom

    Teresa Kennedy-Lydon

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Nunes-Silva, V., Frantz, S., Ramos, G.C. (2017). Lymphocytes at the Heart of Wound Healing. In: Sattler, S., Kennedy-Lydon, T. (eds) The Immunology of Cardiovascular Homeostasis and Pathology. Advances in Experimental Medicine and Biology, vol 1003. Springer, Cham. https://doi.org/10.1007/978-3-319-57613-8_11

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