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Dysmorphic Uterus and Pregnancy Outcomes

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Hysteroscopy

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Abstract

The dysmorphic uteri are rare Müllerian anomalies which have been always underestimated, at the beginning supposed to be present only in case of history of DES exposure, and misdiagnosed due to a lack of clear diagnostic criteria. The new classification system of uterine anomalies from the European Society of Human Reproduction and Embryology and the European Society for Gynaecological Endoscopy includes the “dysmorphic” uteri, represented by T-shaped and tubular-shaped infantilis uteri, in Class U1. Such malformations have been proven to be associated with poor reproductive performance: increased risk of adverse outcomes in pregnancy, such as preterm delivery, SGA, sore fetal presentations, infertility, and miscarriage in the early ages. The novel Hysteroscopic Outpatient Metroplasty to Expand Dysmorphic Uteri (HOME-DU) technique for dysmorphic uteri is associated with a significant improvement of the reproductive outcomes. Macroscopic uterine changes seem to be also associated with variations of endometrial micro-environment.

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Author information

Authors and Affiliations

  1. Department of Public Health, School of Medicine, University of Naples “Federico II”, Naples, Italy

    Attilio Di Spiezio Sardo M.D., Ph.D., Brunella Zizolfi & Carmine Nappi

  2. Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples “Federico II”, Naples, Italy

    Fabrizia Santangelo & Giuseppe Bifulco

  3. Department of Clinical Research, University of Bern, Bern, Switzerland

    Marialuigia Spinelli

Authors
  1. Attilio Di Spiezio Sardo M.D., Ph.D.
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  2. Fabrizia Santangelo
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  3. Brunella Zizolfi
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  4. Marialuigia Spinelli
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  5. Carmine Nappi
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  6. Giuseppe Bifulco
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Corresponding author

Correspondence to Attilio Di Spiezio Sardo M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Department of Obstetrics and Gynaecology, Ospedale Vito Fazzi, Lecce, Italy

    Andrea Tinelli

  2. Hysteroscopy Unit, Gutenberg Institute, Malaga, Spain

    Luis Alonso Pacheco

  3. Hysteroscopy Unit, Hospital Del Mar, Barcelona, Spain

    Sergio Haimovich

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Di Spiezio Sardo, A., Santangelo, F., Zizolfi, B., Spinelli, M., Nappi, C., Bifulco, G. (2018). Dysmorphic Uterus and Pregnancy Outcomes. In: Tinelli, A., Alonso Pacheco, L., Haimovich, S. (eds) Hysteroscopy. Springer, Cham. https://doi.org/10.1007/978-3-319-57559-9_23

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  • DOI: https://doi.org/10.1007/978-3-319-57559-9_23

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-57558-2

  • Online ISBN: 978-3-319-57559-9

  • eBook Packages: MedicineMedicine (R0)

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