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Exploring the Potential of Light to Prevent and Treat Microbial Biofilms in Medical and Food Applications

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Antimicrobial Coatings and Modifications on Medical Devices

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Abstract

Biofilms are complex communities of microbial cells covered in an exopolysaccharide matrix and adhered to a surface. Colonization of medical devices is a significant problem in healthcare-associated infections, especially those related to implanted medical devices such as intravascular catheters and urinary catheters. Recent advances in light technology highlight the potential for light inhibition of biofilm formation in medical devices. This chapter reviews the microbial responses to light, mechanisms of photoinactivation, and some recent research on the use of light to eliminate biofilms. Although light holds a tremendous opportunity to treat antibiotic-resistant infections, challenges in relation to patient safety need to be evaluated. We also discuss some of the research aimed at translating the knowledge into clinical treatment of biofilm-associated infections.

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Authors and Affiliations

  1. Bacterial Stress Response Group, Microbiology, School of Natural Sciences, NUI Galway, Galway, Ireland

    Tara L. Vollmerhausen & Conor P. O’Byrne

  2. National Centre for Laser Applications, School of Physics, NUI Galway, Galway, Ireland

    Alan J. Conneely

Authors
  1. Tara L. Vollmerhausen
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  2. Alan J. Conneely
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  3. Conor P. O’Byrne
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Corresponding author

Correspondence to Conor P. O’Byrne .

Editor information

Editors and Affiliations

  1. Global Advanced Engineering, Teleflex Inc., Cambridge, Massachusetts, USA

    Zheng Zhang

  2. Global Advanced Engineering, Teleflex Inc., Cambridge, Massachusetts, USA

    Victoria E. Wagner

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© 2017 Springer International Publishing AG

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Vollmerhausen, T.L., Conneely, A.J., O’Byrne, C.P. (2017). Exploring the Potential of Light to Prevent and Treat Microbial Biofilms in Medical and Food Applications. In: Zhang, Z., Wagner, V. (eds) Antimicrobial Coatings and Modifications on Medical Devices. Springer, Cham. https://doi.org/10.1007/978-3-319-57494-3_9

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