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Use of Patient-Derived Orthotopic Xenografts (PDOX) to Evaluate Transformative Cancer Therapeutics

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Patient-Derived Mouse Models of Cancer

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Abstract

Patient-derived orthotopic xenografts (PDOX) in nude mice have been shown to replicate the behavior of the tumor in the patient, including metastasis. PDOX models are established with surgical orthotopic implantation (SOI) to ensure optimal replication of patient behavior in the host mouse. The present chapter describes present and future uses of PDOX models to discover and evaluate transformative therapeutics, including tumor-targeting Salmonella typhimurium A1-R, and to individualize molecular-targeting drugs for each cancer patient.

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Authors and Affiliations

  1. AntiCancer, Inc., 7917 Ostrow Street, San Diego, CA, 92111, USA

    Robert M. Hoffman

  2. Department of Surgery, University of California, San Diego, San Diego, CA, USA

    Robert M. Hoffman

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  1. University of California and AntiCancer Inc., San Diego, California, USA

    Robert M. Hoffman

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Hoffman, R.M. (2017). Use of Patient-Derived Orthotopic Xenografts (PDOX) to Evaluate Transformative Cancer Therapeutics. In: Hoffman, R. (eds) Patient-Derived Mouse Models of Cancer . Molecular and Translational Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-57424-0_13

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  • DOI: https://doi.org/10.1007/978-3-319-57424-0_13

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