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GeNeDis 2016 pp 13–21Cite as

Cerebral Thrombosis: A Neurogenetic Approach

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 987))

Abstract

Cerebral venous thrombosis (CVT) is a severe multifactorial condition with various clinical manifestations that may include headache, papilledema, seizures, focal deficits, coma and death. The mortality rate of untreated CVT is up to 50%, but it drops to 10% when CVT is properly treated. Prevention of CVT is feasible through healthy lifestyle, genetic counseling, molecular genetic analysis for common thrombophilia-related mutations, and prophylactic anticoagulative medication.

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References

  1. Bousser, M.G., and J.M. Ferro. 2007. Cerebral Venous Thrombosis: An Update. Lancet Neurology 6: 162–170.

    Article  CAS  PubMed  Google Scholar 

  2. Guenther, G., and A. Arauz. 2011. Cerebral Venous Thrombosis: A Diagnostic and Treatment Update. Neurología 26: 488–498.

    Article  CAS  PubMed  Google Scholar 

  3. Ferro, J.M., and P. Canhão. 2014. Cerebral Venous Sinus Thrombosis: Update on Diagnosis and Management. Current Cardiology Reports 16: 523.

    Article  PubMed  Google Scholar 

  4. Ribes, M.F. 1825. Des recherches faites sur la phlébite. Revue Médicale Francaise et Etrangère et Journal de Clinique de l’Hôtel-Dieu et de la Charité de Paris 3: 5–41.

    Google Scholar 

  5. Abercrombie, J. 1828. Pathological and Practical Researches on the Diseases of the Brain and Spinal Cord, 83–85. Edinburgh: Waugh and Innes.

    Google Scholar 

  6. Ehlers, H., and C.B. Courville. 1936. Thrombosis of Internal Cerebral Veins in Infancy and Childhood. The Journal of Pediatrics 8: 600–623.

    Article  Google Scholar 

  7. Kalbag, R., and A. Woolf. 1967. Cerebral Venous Thrombosis. Oxford: Oxford University Press.

    Google Scholar 

  8. Agnelli, G., and M. Verso. 2008. Epidemiology of Cerebral Vein and Sinus Thrombosis. Frontiers of Neurology and Neuroscience 23: 16–22.

    PubMed  Google Scholar 

  9. Choi, J.C. 2015. Genetics of Cerebral Small Vessel Disease. Journal of Stroke 17: 7–16.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Paraskevas, G.P., V.C. Constantinides, A. Bougea, E. Gerakoulis, C. Yapijakis, E. Kararizou, and E. Kapaki. 2016. Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leucoancepahlopathy Presenting with Postpartum Psychosis and Late-Onset Stroke. Future Neurology 11: 207–213.

    Article  CAS  Google Scholar 

  11. Coutinho, J.M., S.M. Zuurbier, and J. Stam. 2014. Declining Mortality in Cerebral Venous Thrombosis: A Systematic Review. Stroke 45: 1338–1341.

    Article  PubMed  Google Scholar 

  12. Reitsma, P.H. 2015. Genetics in Thrombophilia: An Update. Haemostaseol 35: 47–51.

    Article  CAS  Google Scholar 

  13. Bick, R.L. 2006. Hereditary and Acquired Thrombophilic Disorders. Clinical and Applied Thrombosis/Hemostasis 12: 125–135.

    Article  CAS  PubMed  Google Scholar 

  14. Albisetti, M., A. Moeller, K. Waldvogel, V. Bernet-Buettiker, V. Cannizzaro, A. Anagnostopoulos, C. Balmer, and M. Schmugge. 2007. Congenital Prothrombotic Disorders in Children with Peripheral Venous and Arterial Thromboses. Acta Haematologica 117: 149–155.

    Article  PubMed  Google Scholar 

  15. Gary, T., F. Hafner, H. Froehlich, T. Stojakovic, H. Scharnagl, E. Pilger, and M. Brodmann. 2010. High Factor VIII Activity, High Plasminogen Activator Inhibitor 1 Antigen Levels and Low Factor XII Activity Contribute to a Thrombophilic Tendency in Elderly Venous Thromboembolism Patients. Acta Haematologica 124: 214–217.

    Article  PubMed  Google Scholar 

  16. Lozano, R., M. Naghavi, K. Foreman, et al. 2012. Global and Regional Mortality from 235 Cases of Death for 20 Age Groups in 1990 and 2010. Lancet 380: 2095–2128.

    Article  PubMed  Google Scholar 

  17. Raskob, G.E., P. Angchaisuksiri, A.N. Blanco, H. Buller, A. Gallus, B.J. Hunt, E.M. Hylek, A. Kakkar, S.V. Konstantinides, M. McCumber, Y. Ozaki, A. Wendelboe, and J.I. Weitz. 2014. Thrombosis: A Major Contributor to the Global Disease Burden. Arteriosclerosis, Thrombosis, and Vascular Biology 34: 2363–2371.

    Article  CAS  PubMed  Google Scholar 

  18. Dentali, F., M. Crowther, and W. Ageno. 2006. Thrombophilic Abnormalities, Oral Contraceptives, and Risk of Cerebral Vein Thrombosis: A Meta-Analysis. Blood 107: 2766–2673.

    Article  CAS  PubMed  Google Scholar 

  19. Lane, D.A., and P.J. Grant. 2000. Role of Hemostatic Gene Polymorphisms in Venous and Arterial Thrombotic Disease. Blood 95: 1517–1532.

    CAS  PubMed  Google Scholar 

  20. Yapijakis, C., Z. Serefoglou, and C. Voumvourakis. 2015. Common Gene Polymorphisms Associated with Thrombophilia. In Thrombosis, Atherosclerosis and Atherothrombosis - New Insights and Experimental Protocols, ed. Mojca Bozic-Mijovski. InTech Publications, Rijeka, Croatia.

    Google Scholar 

  21. Yapijakis, C., Z. Serefoglou, A.M. Nixon, A. Vylliotis, V. Ragos, and E. Vairaktaris. 2012. Prevalence of Thrombosis-Related DNA Polymorphisms in a Healthy Greek Population. In Vivo 26: 1095–1102.

    CAS  PubMed  Google Scholar 

  22. de Bruijn, S.F., J. Stam, M.M. Koopman, and J.P. Vandenbroucke. 1998. Case Control Study of Risk of Cerebral Sinus Thrombosis in Oral Contraceptive Users who are Carriers of Hereditary Prothrombotic Conditions. British Medical Journal 316: 589–592.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Amoozegar, F., P.E. Ronksley, R. Sauve, and B.K. Menon. 2015. Hormonal Contraceptives and Cerebral Venous Thrombosis Risk: A Systematic Review and Meta-Analysis. Frontiers in Neurology 6: 7.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Gurfinkel, E.P., G.E. Bozovich, O. Dabbous, B. Mautner, and F. Anderson. 2005. Socio-Economic Crisis and Mortality. Epidemiological Testimony of the Financial Collapse of Argentina. Thrombosis Journal 3: 22.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Makaris, E., G. Michas, R. Micha, D. Gkotsis, C. Panotopoulos, I. Pisimisis, D. Svoronos, I. Tsichlis, G. Koudounis, G. Asimakis, and S. Zobolos. 2013. Greek Socio-Economic Crisis and Incidence of Acute Myocardial Infarction. International Journal of Cardiology 168: 4886–4887.

    Article  PubMed  Google Scholar 

  26. Andreou, A., C. Papapetrou, K. Papadimitriou, D. Avgoustidis, and C. Yapijakis. 2015. Cerebrovascular Aneurysms may be Associated with Thrombophilia-Predisposing Mutations in Patients with Familial Risk. In Vivo 29: 395–398.

    CAS  PubMed  Google Scholar 

  27. Cardiovascular Disease Educational and Research Trust, Cyprus Cardiovascular Disease Educational and Research Trust, European Venous Forum, International Surgical Thrombosis Forum, International Union of Angiology, Union Internationale de Phlébologie. 2006. Prevention and Treatment of Venous Thromboembolism: International Consensus Statement (Guidelines According to Scientific Evidence). International Angiology 25: 101–161.

    Google Scholar 

  28. Federici, C., J. Gianetti, and M.G. Andreassi. 2006. Genomic Medicine and Thrombotic Risk: Who, When, How and Why? International Journal of Cardiology 106: 3–9.

    Article  PubMed  Google Scholar 

  29. Reich, L.M., M. Bower, and N.S. Keys. 2003. Role of the Geneticist in Testing and Counseling for Inherited Thrombophilia. Genetics in Medicine 5: 133–143.

    Article  PubMed  Google Scholar 

  30. Langlois, N.J., and P.S. Wells. 2003. Risk of Venous Thromboembolism in Relatives of Symptomatic Probands with Thrombophilia: A Systematic Review. Thrombosis and Haemostasis 90: 17–26.

    CAS  PubMed  Google Scholar 

  31. Selby, R., W. Geerts, F.A. Ofosu, S. Craven, L. Dewar, A. Phillips, and J.P. Szalai. 2009. Hypercoagulability After Trauma: Hemostatic Changes and Relationship to Venous Thromboembolism. Thrombosis Research 124: 281–287.

    Article  CAS  PubMed  Google Scholar 

  32. Taniguchi, S., I. Fukuda, K. Daitoku, M. Minakawa, S. Odagiri, Y. Suzuki, K. Fukui, K. Asano, and H. Ohkuma. 2009. Prevalence of Venous Thromboembolism in Neurosurgical Patients. Heart and Vessels 24: 425–428.

    Article  PubMed  Google Scholar 

  33. De Stefano, V., I. Martinelli, P.M. Mannucci, K. Paciaroni, P. Chiusolo, I. Casorelli, E. Rossi, and G. Leone. 1999. The Risk of Recurrent Deep Venous Thrombosis among Heterozygous Carriers of Both Factor V Leiden and the G20210A Prothrombin Mutation. The New England Journal of Medicine 341: 801–806.

    Article  PubMed  Google Scholar 

  34. Yapijakis, C., T. Antoniadi, K. Salavoura, C. Voumvourakis, and E. Vairaktaris. 2012. Potential Prevention of Thromboembolism by Genetic Counseling and Testing for Two Common Thrombophilia Mutations. In Vivo 26: 165–172.

    PubMed  Google Scholar 

  35. Yapijakis, C. 2009. Hippocrates of Kos, the Father of Clinical Medicine, and Asclepiades of Bithynia, the Father of Molecular Medicine. In Vivo 23: 507–514.

    PubMed  Google Scholar 

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Acknowledgements

The author is thankful to Dr. Thalia Antoniadi for discussions in initial stage of thrombophilia research and hundreds of patients with family history of thrombophilia that relied to him for genetic counseling for about two decades. This text is dedicated to deceased friend and colleague Dr. Nikos Koufaliotis.

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, School of Medicine, University of Athens, Attikon Hospital, Athens, Greece

    Christos Yapijakis

  2. “Cephalogenetics” Genetic Center, Athens, Greece

    Christos Yapijakis

  3. Department of Neurology, School of Medicine, University of Athens, Eginition Hospital, Athens, Greece

    Christos Yapijakis

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  1. Christos Yapijakis
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Correspondence to Christos Yapijakis .

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Editors and Affiliations

  1. Department of Informatics, Bioinformatics and Human Electrophysiology Laboratory, Ionian University, Corfu, Greece

    Panayiotis Vlamos

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Yapijakis, C. (2017). Cerebral Thrombosis: A Neurogenetic Approach. In: Vlamos, P. (eds) GeNeDis 2016. Advances in Experimental Medicine and Biology, vol 987. Springer, Cham. https://doi.org/10.1007/978-3-319-57379-3_2

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