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Endocannabinoid-Dependent Synaptic Plasticity in the Striatum

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Endocannabinoids and Lipid Mediators in Brain Functions

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Abstract

The striatum plays a critical role in mediating the goal-directed and habitual behaviors involved in the development of drug abuse and addiction. Cannabinoid receptor-dependent synaptic plasticity is a prominent regulator of striatal circuit function. It is increasingly clear that striatal endocannabinoid signaling impacts the development of drug abuse. The expression of endocannabinoid-mediated plasticity in the striatum is affected by disparate types of drugs of abuse, such as opiates and alcohol. Understanding the mechanism of endocannabinoid-mediated plasticity and its effects on striatal circuit function may elucidate how endocannabinoids shape addiction-related behavior and perhaps offer new therapeutic avenues for treating drug abuse.

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Authors and Affiliations

  1. Department of Psychiatry, Department of Pharmacology & Toxicology, Indiana University School of Medicine, Indianapolis, IN, USA

    Brady K. Atwood

  2. Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA

    David M. Lovinger

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  1. Dept Biomedical Sciences, Division of Neuroscience and Clinical Pharmacology, University of Cagliari, Cagliari, Italy

    Miriam Melis

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Atwood, B.K., Lovinger, D.M. (2017). Endocannabinoid-Dependent Synaptic Plasticity in the Striatum. In: Melis, M. (eds) Endocannabinoids and Lipid Mediators in Brain Functions. Springer, Cham. https://doi.org/10.1007/978-3-319-57371-7_5

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