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Understanding Mood Disorders Using Electrophysiology and Circuit Breaking

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Decoding Neural Circuit Structure and Function

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Abstract

Mood disorders such as major depressive disorders are predicted to increase globally and according to the World Health Organization (WHO), it will become a leading contributor to the global burden of disease over the next few years. Pathophysiology of mood and reward processing leads to mood disorders such as anxiety, depression and addiction. Comorbidity of these disorders in a majority of patients implies that overlapping brain regions most likely regulate these processes. Evidence from the literature described in this chapter suggests that the multiplicity of symptoms related to mood disorders most likely is the result of aberrations in different aspects of normal neural functions ranging from the molecular up to the neural circuit. This review synthesizes findings from rodent studies from which emerges a role for different, yet interconnected, molecular systems and associated neural circuits to the aetiology of depression. Thus, in order to develop more effective and faster acting treatments for mood disorders such as depression, much work is still needed in understanding how exposure to stress lead to the sequence of changes in molecular, genetic/epigenetic processes and eventually neural circuit signalling. Using the combination of animal models of mood disorders together with the development of novel and sophisticated technologies to study molecular, genetic and neural circuit changes, there is a good possibility for the development of newer and better therapeutics for the treatment of mental disorders in the near future.

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References

  • Adhikari A (2014) Distributed circuits underlying anxiety. Front Behav Neurosci 8:112

    Article  PubMed  PubMed Central  Google Scholar 

  • Albin RL, Young AB, Penney JB (1989) The functional anatomy of basal ganglia disorders. Trends Neurosci 12:366–375

    Article  CAS  PubMed  Google Scholar 

  • Ambroggi F, Ishikawa A, Fields HL, Nicola SM (2008) Basolateral amygdala neurons facilitate reward-seeking behavior by exciting nucleus accumbens neurons. Neuron 59:648–661

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Anstrom KK, Miczek KA, Budygin EA (2009) Increased phasic dopamine signaling in the mesolimbic pathway during social defeat in rats. Neuroscience 161:3–12

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bagot RC, Parise EM, Pena CJ, Zhang HX, Maze I, Chaudhury D, Persaud B, Cachope R, Bolanos-Guzman CA, Cheer JF, Deisseroth K, Han MH, Nestler EJ (2015) Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression. Nat Commun 6:7062

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Balleine BW, Killcross S (2006) Parallel incentive processing: an integrated view of amygdala function. Trends Neurosci 29:272–279

    Article  CAS  PubMed  Google Scholar 

  • Beck A, Heinz AJ, Heinz A (2014) Translational clinical neuroscience perspectives on the cognitive and neurobiological mechanisms underlying alcohol-related aggression. Curr Top Behav Neurosci 17:443–474

    Article  PubMed  Google Scholar 

  • Belujon P, Grace AA (2014) Restoring mood balance in depression: ketamine reverses deficit in dopamine-dependent synaptic plasticity. Biol Psychiatry 76:927–936

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Belzung C, Willner P, Philippot P (2015) Depression: from psychopathology to pathophysiology. Curr Opin Neurobiol 30:24–30

    Article  CAS  PubMed  Google Scholar 

  • Berlim MT, McGirr A, Van den Eynde F, Fleck MP, Giacobbe P (2014) Effectiveness and acceptability of deep brain stimulation (DBS) of the subgenual cingulate cortex for treatment-resistant depression: a systematic review and exploratory meta-analysis. J Affect Disord 159:31–38

    Article  PubMed  Google Scholar 

  • Berton O, Nestler EJ (2006) New approaches to antidepressant drug discovery: beyond monoamines. Nat Rev Neurosci 7:137–151

    Article  CAS  PubMed  Google Scholar 

  • Berton O, McClung CA, Dileone RJ, Krishnan V, Renthal W, Russo SJ, Graham D, Tsankova NM, Bolanos CA, Rios M, Monteggia LM, Self DW, Nestler EJ (2006) Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science 311:864–868

    Article  CAS  PubMed  Google Scholar 

  • Bogod NM, Sinden M, Woo C, Defreitas VG, Torres IJ, Howard AK, Ilcewicz-Klimek MI, Honey CR, Yatham LN, Lam RW (2014) Long-term neuropsychological safety of subgenual cingulate gyrus deep brain stimulation for treatment-resistant depression. J Neuropsychiatry Clin Neurosci 26:126–133

    Article  PubMed  Google Scholar 

  • Bredt DS, Nicoll RA (2003) AMPA receptor trafficking at excitatory synapses. Neuron 40:361–379

    Article  CAS  PubMed  Google Scholar 

  • Brischoux F, Chakraborty S, Brierley DI, Ungless MA (2009) Phasic excitation of dopamine neurons in ventral VTA by noxious stimuli. Proc Natl Acad Sci U S A 106:4894–4899

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bruzos-Cidon C, Miguelez C, Rodriguez JJ, Gutierrez-Lanza R, Ugedo L, Torrecilla M (2014) Altered neuronal activity and differential sensitivity to acute antidepressants of locus coeruleus and dorsal raphe nucleus in Wistar Kyoto rats: a comparative study with Sprague Dawley and Wistar rats. Eur Neuropsychopharmacol 24:1112–1122

    Article  CAS  PubMed  Google Scholar 

  • Bruzos-Cidon C, Llamosas N, Ugedo L, Torrecilla M (2015) Dysfunctional inhibitory mechanisms in locus coeruleus neurons of the wistar kyoto rat. Int J Neuropsychopharmacol 18:pyu122

    Google Scholar 

  • Cacioppo JT, Hughes ME, Waite LJ, Hawkley LC, Thisted RA (2006) Loneliness as a specific risk factor for depressive symptoms: cross-sectional and longitudinal analyses. Psychol Aging 21:140–151

    Article  PubMed  Google Scholar 

  • Cador M, Robbins TW, Everitt BJ (1989) Involvement of the amygdala in stimulus-reward associations: interaction with the ventral striatum. Neuroscience 30:77–86

    Article  CAS  PubMed  Google Scholar 

  • Cao JL, Covington HE 3rd, Friedman AK, Wilkinson MB, Walsh JJ, Cooper DC, Nestler EJ, Han MH (2010) Mesolimbic dopamine neurons in the brain reward circuit mediate susceptibility to social defeat and antidepressant action. J Neurosci 30:16453–16458

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Carlezon WA Jr, Thomas MJ (2009) Biological substrates of reward and aversion: a nucleus accumbens activity hypothesis. Neuropharmacology 56(Suppl 1):122–132

    Article  CAS  PubMed  Google Scholar 

  • Chakravarthy S, Saiepour MH, Bence M, Perry S, Hartman R, Couey JJ, Mansvelder HD, Levelt CN (2006) Postsynaptic TrkB signaling has distinct roles in spine maintenance in adult visual cortex and hippocampus. Proc Natl Acad Sci U S A 103:1071–1076

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Challis C, Boulden J, Veerakumar A, Espallergues J, Vassoler FM, Pierce RC, Beck SG, Berton O (2013) Raphe GABAergic neurons mediate the acquisition of avoidance after social defeat. J Neurosci 33(13978–13988):13988a

    Google Scholar 

  • Challis C, Beck SG, Berton O (2014) Optogenetic modulation of descending prefrontocortical inputs to the dorsal raphe bidirectionally bias socioaffective choices after social defeat. Front Behav Neurosci 8:43

    Article  PubMed  PubMed Central  Google Scholar 

  • Chandley MJ, Szebeni A, Szebeni K, Crawford JD, Stockmeier CA, Turecki G, Kostrzewa RM, Ordway GA (2014) Elevated gene expression of glutamate receptors in noradrenergic neurons from the locus coeruleus in major depression. Int J Neuropsychopharmacol 17:1569–1578

    Article  CAS  PubMed  Google Scholar 

  • Chang CH, Grace AA (2014) Amygdala-ventral pallidum pathway decreases dopamine activity after chronic mild stress in rats. Biol Psychiatry 76:223–230

    Article  CAS  PubMed  Google Scholar 

  • Chang CH, Grace AA (2015) Dopaminergic modulation of lateral amygdala neuronal activity: differential D1 and D2 receptor effects on thalamic and cortical afferent inputs. Int J Neuropsychopharmacol 18:pyv015

    Google Scholar 

  • Charney DS, Dejesus G, Manji HK (2004) Cellular plasticity and resilience and the pathophysiology of severe mood disorders. Dialogues Clin Neurosci 6:217–225

    PubMed  PubMed Central  Google Scholar 

  • Chaudhury D, Walsh JJ, Friedman AK, Juarez B, Ku SM, Koo JW, Ferguson D, Tsai HC, Pomeranz L, Christoffel DJ, Nectow AR, Ekstrand M, Domingos A, Mazei-Robison MS, Mouzon E, Lobo MK, Neve RL, Friedman JM, Russo SJ, Deisseroth K, Nestler EJ, Han MH (2013) Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons. Nature 493:532–536

    Article  CAS  PubMed  Google Scholar 

  • Christoffel DJ, Golden SA, Dumitriu D, Robison AJ, Janssen WG, Ahn HF, Krishnan V, Reyes CM, Han MH, Ables JL, Eisch AJ, Dietz DM, Ferguson D, Neve RL, Greengard P, Kim Y, Morrison JH, Russo SJ (2011) IkappaB kinase regulates social defeat stress-induced synaptic and behavioral plasticity. J Neurosci 31:314–321

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chuhma N, Zhang H, Masson J, Zhuang X, Sulzer D, Hen R, Rayport S (2004) Dopamine neurons mediate a fast excitatory signal via their glutamatergic synapses. J Neurosci 24:972–981

    Article  CAS  PubMed  Google Scholar 

  • Clarke NP, Bolam JP, Bevan MD (1996) Glutamate-enriched inputs from the mesopontine tegmentum to the entopeduncular nucleus in the rat. Eur J Neurosci 8:1363–1376

    Article  CAS  PubMed  Google Scholar 

  • Conrad KL, Tseng KY, Uejima JL, Reimers JM, Heng LJ, Shaham Y, Marinelli M, Wolf ME (2008) Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving. Nature 454:118–121

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Covington HE 3rd, Lobo MK, Maze I, Vialou V, Hyman JM, Zaman S, LaPlant Q, Mouzon E, Ghose S, Tamminga CA, Neve RL, Deisseroth K, Nestler EJ (2010) Antidepressant effect of optogenetic stimulation of the medial prefrontal cortex. J Neurosci 30:16082–16090

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Curtis AL, Bello NT, Connolly KR, Valentino RJ (2002) Corticotropin-releasing factor neurones of the central nucleus of the amygdala mediate locus coeruleus activation by cardiovascular stress. J Neuroendocrinol 14:667–682

    Article  CAS  PubMed  Google Scholar 

  • Davis M, Walker DL, Miles L, Grillon C (2010) Phasic vs sustained fear in rats and humans: role of the extended amygdala in fear vs anxiety. Neuropsychopharmacology 35:105–135

    Google Scholar 

  • Di Ciano P, Everitt BJ (2004) Direct interactions between the basolateral amygdala and nucleus accumbens core underlie cocaine-seeking behavior by rats. J Neurosci 24:7167–7173

    Article  PubMed  CAS  Google Scholar 

  • Dipesh Chaudhury HZ, Juarez B, Friedman A, Ku S, Han MH (2014) Lateral habenula projections to a subset of ventral tegmental area neurons rapidly encodes for susceptibility to social defeat stress. Soc Neurosci Abs

    Google Scholar 

  • Dobrossy MD, Furlanetti LL, Coenen VA (2015) Electrical stimulation of the medial forebrain bundle in pre-clinical studies of psychiatric disorders. Neurosci Biobehav Rev 49:32–42

    Article  PubMed  Google Scholar 

  • Dolen G, Darvishzadeh A, Huang KW, Malenka RC (2013) Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin. Nature 501:179–184

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Duvarci S, Bauer EP, Pare D (2009) The bed nucleus of the stria terminalis mediates inter-individual variations in anxiety and fear. J Neurosci 29:10357–10361

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • El-Sayed AM, Palma A, Freedman LP, Kruk ME (2015) Does health insurance mitigate inequities in non-communicable disease treatment? Evidence from 48 low- and middle-income countries. Health Policy 119:1164–1175

    Article  PubMed  Google Scholar 

  • Espana RA, Scammell TE (2011) Sleep neurobiology from a clinical perspective. Sleep 34:845–858

    PubMed  PubMed Central  Google Scholar 

  • Falkner AL, Grosenick L, Davidson TJ, Deisseroth K, Lin D (2016) Hypothalamic control of male aggression-seeking behavior. Nat Neurosci 19:596–604

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ferraro G, Montalbano ME, Sardo P, La Grutta V (1996) Lateral habenular influence on dorsal raphe neurons. Brain Res Bull 41:47–52

    Article  CAS  PubMed  Google Scholar 

  • Francis D, Diorio J, Liu D, Meaney MJ (1999) Nongenomic transmission across generations of maternal behavior and stress responses in the rat. Science 286:1155–1158

    Article  CAS  PubMed  Google Scholar 

  • Francis TC, Chaudhury D, Lobo MK (2014) Optogenetics: illuminating the neural basis of rodent behavior. Open Access Anim Physiol 6:33–51

    Google Scholar 

  • Francis TC, Chandra R, Friend DM, Finkel E, Dayrit G, Miranda J, Brooks JM, Iniguez SD, O’Donnell P, Kravitz A, Lobo MK (2015) Nucleus accumbens medium spiny neuron subtypes mediate depression-related outcomes to social defeat stress. Biol Psychiatry 77:212–222

    Article  PubMed  Google Scholar 

  • Freeze BS, Kravitz AV, Hammack N, Berke JD, Kreitzer AC (2013) Control of basal ganglia output by direct and indirect pathway projection neurons. J Neurosci 33:18531–18539

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Friedman AK, Walsh JJ, Juarez B, Ku SM, Chaudhury D, Wang J, Li X, Dietz DM, Pan N, Vialou VF, Neve RL, Yue Z, Han MH (2014) Enhancing depression mechanisms in midbrain dopamine neurons achieves homeostatic resilience. Science 344:313–319

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Friedman AK, Juarez B, Ku SM, Zhang H, Calizo RC, Walsh JJ, Chaudhury D, Zhang S, Hawkins A, Dietz DM, Murrough JW, Ribadeneira M, Wong EH, Neve RL, Han MH (2016) KCNQ channel openers reverse depressive symptoms via an active resilience mechanism. Nat Commun 7:11671

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Golden SA, Heshmati M, Flanigan M, Christoffel DJ, Guise K, Pfau ML, Aleyasin H, Menard C, Zhang H, Hodes GE, Bregman D, Khibnik L, Tai J, Rebusi N, Krawitz B, Chaudhury D, Walsh JJ, Han MH, Shapiro ML, Russo SJ (2016) Basal forebrain projections to the lateral habenula modulate aggression reward. Nature 534:688–692

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Goldwater DS, Pavlides C, Hunter RG, Bloss EB, Hof PR, McEwen BS, Morrison JH (2009) Structural and functional alterations to rat medial prefrontal cortex following chronic restraint stress and recovery. Neuroscience 164:798–808

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Goto Y, Grace AA (2005a) Dopamine-dependent interactions between limbic and prefrontal cortical plasticity in the nucleus accumbens: disruption by cocaine sensitization. Neuron 47:255–266

    Article  CAS  PubMed  Google Scholar 

  • Goto Y, Grace AA (2005b) Dopaminergic modulation of limbic and cortical drive of nucleus accumbens in goal-directed behavior. Nat Neurosci 8:805–812

    Article  CAS  PubMed  Google Scholar 

  • Grace AA, Bunney BS (1983) Intracellular and extracellular electrophysiology of nigral dopaminergic neurons–3. Evidence for electrotonic coupling. Neuroscience 10:333–348

    Article  CAS  PubMed  Google Scholar 

  • Grace AA, Floresco SB, Goto Y, Lodge DJ (2007) Regulation of firing of dopaminergic neurons and control of goal-directed behaviors. Trends Neurosci 30:220–227

    Article  CAS  PubMed  Google Scholar 

  • Guiard BP, El Mansari M, Merali Z, Blier P (2008) Functional interactions between dopamine, serotonin and norepinephrine neurons: an in-vivo electrophysiological study in rats with monoaminergic lesions. Int J Neuropsychopharmacol 11:625–639

    Article  CAS  PubMed  Google Scholar 

  • Gunaydin LA, Grosenick L, Finkelstein JC, Kauvar IV, Fenno LE, Adhikari A, Lammel S, Mirzabekov JJ, Airan RD, Zalocusky KA, Tye KM, Anikeeva P, Malenka RC, Deisseroth K (2014) Natural neural projection dynamics underlying social behavior. Cell 157:1535–1551

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Han MH, Friedman AK (2012) Virogenetic and optogenetic mechanisms to define potential therapeutic targets in psychiatric disorders. Neuropharmacology 62:89–100

    Article  CAS  PubMed  Google Scholar 

  • Henriques-Alves AM, Queiroz CM (2015) Ethological evaluation of the effects of social defeat stress in mice: beyond the social interaction ratio. Front Behav Neurosci 9:364

    PubMed  Google Scholar 

  • Hnasko TS, Edwards RH (2012) Neurotransmitter corelease: mechanism and physiological role. Annu Rev Physiol 74:225–243

    Article  CAS  PubMed  Google Scholar 

  • Hnasko TS, Chuhma N, Zhang H, Goh GY, Sulzer D, Palmiter RD, Rayport S, Edwards RH (2010) Vesicular glutamate transport promotes dopamine storage and glutamate corelease in vivo. Neuron 65:643–656

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hnasko TS, Hjelmstad GO, Fields HL, Edwards RH (2012) Ventral tegmental area glutamate neurons: electrophysiological properties and projections. J Neurosci 32:15076–15085

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Holt-Lunstad J, Smith TB, Layton JB (2010) Social relationships and mortality risk: a meta-analytic review. PLoS Med 7:e1000316

    Article  PubMed  PubMed Central  Google Scholar 

  • Holtmaat A, Svoboda K (2009) Experience-dependent structural synaptic plasticity in the mammalian brain. Nat Rev Neurosci 10:647–658

    Article  CAS  PubMed  Google Scholar 

  • Holtzheimer PE 3rd, Mayberg HS (2010) Deep brain stimulation for treatment-resistant depression. Am J Psychiatry 167:1437–1444

    Article  PubMed  PubMed Central  Google Scholar 

  • House JS, Landis KR, Umberson D (1988) Social relationships and health. Science 241:540–545

    Article  CAS  PubMed  Google Scholar 

  • Hu L, Jing XH, Cui CL, Xing GG, Zhu B (2014) NMDA receptors in the midbrain play a critical role in dopamine-mediated hippocampal synaptic potentiation caused by morphine. Addict Biol 19:380–391

    Article  CAS  PubMed  Google Scholar 

  • Isingrini E, Perret L, Rainer Q, Amilhon B, Guma E, Tanti A, Martin G, Robinson J, Moquin L, Marti F, Mechawar N, Williams S, Gratton A, Giros B (2016) Resilience to chronic stress is mediated by noradrenergic regulation of dopamine neurons. Nat Neurosci 19:560–563

    Article  CAS  PubMed  Google Scholar 

  • Jennings JH, Sparta DR, Stamatakis AM, Ung RL, Pleil KE, Kash TL, Stuber GD (2013) Distinct extended amygdala circuits for divergent motivational states. Nature 496:224–228

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ji H, Shepard PD (2007) Lateral habenula stimulation inhibits rat midbrain dopamine neurons through a GABA(A) receptor-mediated mechanism. J Neurosci 27:6923–6930

    Article  CAS  PubMed  Google Scholar 

  • Johnson LR, Hou M, Prager EM, Ledoux JE (2011) Regulation of the fear network by mediators of stress: norepinephrine alters the balance between cortical and subcortical afferent excitation of the lateral amygdala. Front Behav Neurosci 5:23

    Article  PubMed  PubMed Central  Google Scholar 

  • Kauer JA, Malenka RC (2007) Synaptic plasticity and addiction. Nat Rev Neurosci 8:844–858

    Article  CAS  PubMed  Google Scholar 

  • Kim SY, Adhikari A, Lee SY, Marshel JH, Kim CK, Mallory CS, Lo M, Pak S, Mattis J, Lim BK, Malenka RC, Warden MR, Neve R, Tye KM, Deisseroth K (2013) Diverging neural pathways assemble a behavioural state from separable features in anxiety. Nature 496:219–223

    Article  CAS  PubMed  Google Scholar 

  • Koob GF (2008) A role for brain stress systems in addiction. Neuron 59:11–34

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kravitz AV, Kreitzer AC (2012) Striatal mechanisms underlying movement, reinforcement, and punishment. Physiology 27:167–177

    Article  PubMed  Google Scholar 

  • Krishnan V, Han MH, Graham DL, Berton O, Renthal W, Russo SJ, Laplant Q, Graham A, Lutter M, Lagace DC, Ghose S, Reister R, Tannous P, Green TA, Neve RL, Chakravarty S, Kumar A, Eisch AJ, Self DW, Lee FS, Tamminga CA, Cooper DC, Gershenfeld HK, Nestler EJ (2007) Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell 131:391–404

    Article  CAS  PubMed  Google Scholar 

  • Lammel S, Ion DI, Roeper J, Malenka RC (2011) Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli. Neuron 70:855–862

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lammel S, Lim BK, Ran C, Huang KW, Betley MJ, Tye KM, Deisseroth K, Malenka RC (2012) Input-specific control of reward and aversion in the ventral tegmental area. Nature 491:212–217

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lammel S, Lim BK, Malenka RC (2014) Reward and aversion in a heterogeneous midbrain dopamine system. Neuropharmacology 76 Pt B:351–359

    Google Scholar 

  • Lecca S, Meye FJ, Mameli M (2014) The lateral habenula in addiction and depression: an anatomical, synaptic and behavioral overview. Eur J Neurosci 39:1170–1178

    Article  PubMed  Google Scholar 

  • LeDoux JE (2000) Emotion circuits in the brain. Annu Rev Neurosci 23:155–184

    Article  CAS  PubMed  Google Scholar 

  • LeDoux J (2003) The emotional brain, fear, and the amygdala. Cell Mol Neurobiol 23:727–738

    Article  PubMed  Google Scholar 

  • Lenz JD, Lobo MK (2013) Optogenetic insights into striatal function and behavior. Behav Brain Res 255:44–54

    Article  CAS  PubMed  Google Scholar 

  • Li B, Piriz J, Mirrione M, Chung C, Proulx CD, Schulz D, Henn F, Malinow R (2011) Synaptic potentiation onto habenula neurons in the learned helplessness model of depression. Nature 470:535–539

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Li DP, Byan HS, Pan HL (2012) Switch to glutamate receptor 2-lacking AMPA receptors increases neuronal excitability in hypothalamus and sympathetic drive in hypertension. J Neurosci 32:372–380

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Li K, Zhou T, Liao L, Yang Z, Wong C, Henn F, Malinow R, Yates JR 3rd, Hu H (2013) βCaMKII in lateral habenula mediates core symptoms of depression. Science 341:1016–1020

    Google Scholar 

  • Lim BK, Huang KW, Grueter BA, Rothwell PE, Malenka RC (2012) Anhedonia requires MC4R-mediated synaptic adaptations in nucleus accumbens. Nature 487:183–189

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lim LW, Prickaerts J, Huguet G, Kadar E, Hartung H, Sharp T, Temel Y (2015) Electrical stimulation alleviates depressive-like behaviors of rats: investigation of brain targets and potential mechanisms. Transl Psychiatry 5:e535

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lobo MK, Nestler EJ (2011) The striatal balancing act in drug addiction: distinct roles of direct and indirect pathway medium spiny neurons. Front Neuroanat 5:41

    Article  PubMed  PubMed Central  Google Scholar 

  • Lobo MK, Zaman S, Damez-Werno DM, Koo JW, Bagot RC, DiNieri JA, Nugent A, Finkel E, Chaudhury D, Chandra R, Riberio E, Rabkin J, Mouzon E, Cachope R, Cheer JF, Han MH, Dietz DM, Self DW, Hurd YL, Vialou V, Nestler EJ (2013) DeltaFosB induction in striatal medium spiny neuron subtypes in response to chronic pharmacological, emotional, and optogenetic stimuli. J Neurosci 33:18381–18395

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lüscher C, Malenka RC (2012) NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). Cold Spring Harb Perspect Biol 4

    Google Scholar 

  • Luscher B, Shen Q, Sahir N (2011) The GABAergic deficit hypothesis of major depressive disorder. Mol Psychiatry 16:383–406

    Article  CAS  PubMed  Google Scholar 

  • Maia TV, Frank MJ (2011) From reinforcement learning models to psychiatric and neurological disorders. Nat Neurosci 14:154–162

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mameli M, Halbout B, Creton C, Engblom D, Parkitna JR, Spanagel R, Luscher C (2009) Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc. Nat Neurosci 12:1036–1041

    Article  CAS  PubMed  Google Scholar 

  • Mameli M, Bellone C, Brown MT, Luscher C (2011) Cocaine inverts rules for synaptic plasticity of glutamate transmission in the ventral tegmental area. Nat Neurosci 14:414–416

    Article  CAS  PubMed  Google Scholar 

  • Maren S, Quirk GJ (2004) Neuronal signalling of fear memory. Nat Rev Neurosci 5:844–852

    Article  CAS  PubMed  Google Scholar 

  • Martin LA, Neighbors HW, Griffith DM (2013) The experience of symptoms of depression in men vs women: analysis of the national comorbidity survey replication. JAMA Psychiatry 70:1100–1106

    Article  PubMed  Google Scholar 

  • Maskos U (2008) The cholinergic mesopontine tegmentum is a relatively neglected nicotinic master modulator of the dopaminergic system: relevance to drugs of abuse and pathology. Br J Pharmacol 153(Suppl 1):S438–S445

    CAS  PubMed  PubMed Central  Google Scholar 

  • McClung CA, Nestler EJ (2003) Regulation of gene expression and cocaine reward by CREB and DeltaFosB. Nat Neurosci 6:1208–1215

    Article  CAS  PubMed  Google Scholar 

  • McDevitt RA, Tiran-Cappello A, Shen H, Balderas I, Britt JP, Marino RA, Chung SL, Richie CT, Harvey BK, Bonci A (2014) Serotonergic versus nonserotonergic dorsal raphe projection neurons: differential participation in reward circuitry. Cell Rep 8:1857–1869

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • McEwen BS (2007) Physiology and neurobiology of stress and adaptation: central role of the brain. Physiol Rev 87:873–904

    Article  PubMed  Google Scholar 

  • Meaney MJ (2001) Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. Annu Rev Neurosci 24:1161–1192

    Article  CAS  PubMed  Google Scholar 

  • Michelsen KA, Prickaerts J, Steinbusch HW (2008) The dorsal raphe nucleus and serotonin: implications for neuroplasticity linked to major depression and Alzheimer’s disease. Prog Brain Res 172:233–264

    Article  CAS  PubMed  Google Scholar 

  • Namburi P, Beyeler A, Yorozu S, Calhoon GG, Halbert SA, Wichmann R, Holden SS, Mertens KL, Anahtar M, Felix-Ortiz AC, Wickersham IR, Gray JM, Tye KM (2015) A circuit mechanism for differentiating positive and negative associations. Nature 520:675–678

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nestler EJ (2002) From neurobiology to treatment: progress against addiction. Nat Neurosci 5(Suppl):1076–1079

    Article  CAS  PubMed  Google Scholar 

  • Nestler EJ, Carlezon WA Jr (2006) The mesolimbic dopamine reward circuit in depression. Biol Psychiatry 59:1151–1159

    Article  CAS  PubMed  Google Scholar 

  • Neuhoff H, Neu A, Liss B, Roeper J (2002) I(h) channels contribute to the different functional properties of identified dopaminergic subpopulations in the midbrain. J Neurosci 22:1290–1302

    CAS  PubMed  Google Scholar 

  • Nicola SM (2007) The nucleus accumbens as part of a basal ganglia action selection circuit. Psychopharmacology 191:521–550

    Article  CAS  PubMed  Google Scholar 

  • Nieh EH, Vander Weele CM, Matthews GA, Presbrey KN, Wichmann R, Leppla CA, Izadmehr EM, Tye KM (2016) Inhibitory input from the lateral hypothalamus to the ventral tegmental area disinhibits dopamine neurons and promotes behavioral activation. Neuron 1286–1298

    Google Scholar 

  • Non AL, Binder AM, Kubzansky LD, Michels KB (2014) Genome-wide DNA methylation in neonates exposed to maternal depression, anxiety, or SSRI medication during pregnancy. Epigenetics Off J DNA Methyl Soc 9:964–972

    Article  Google Scholar 

  • O’Donnell P, Grace AA (1994) Tonic D2-mediated attenuation of cortical excitation in nucleus accumbens neurons recorded in vitro. Brain Res 634:105–112

    Article  PubMed  Google Scholar 

  • Paton JJ, Belova MA, Morrison SE, Salzman CD (2006) The primate amygdala represents the positive and negative value of visual stimuli during learning. Nature 439:865–870

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pezze MA, Feldon J (2004) Mesolimbic dopaminergic pathways in fear conditioning. Prog Neurobiol 74:301–320

    Article  CAS  PubMed  Google Scholar 

  • Radley JJ, Rocher AB, Miller M, Janssen WG, Liston C, Hof PR, McEwen BS, Morrison JH (2006) Repeated stress induces dendritic spine loss in the rat medial prefrontal cortex. Cereb Cortex 16:313–320

    Article  PubMed  Google Scholar 

  • Razzoli M, Andreoli M, Michielin F, Quarta D, Sokal DM (2011) Increased phasic activity of VTA dopamine neurons in mice 3 weeks after repeated social defeat. Behav Brain Res 218:253–257

    Article  CAS  PubMed  Google Scholar 

  • Rebec GV, Christensen JR, Guerra C, Bardo MT (1997) Regional and temporal differences in real-time dopamine efflux in the nucleus accumbens during free-choice novelty. Brain Res 776:61–67

    Article  CAS  PubMed  Google Scholar 

  • Reimer RJ, Edwards RH (2004) Organic anion transport is the primary function of the SLC17/type I phosphate transporter family. Pflugers Arch 447:629–635

    Article  CAS  PubMed  Google Scholar 

  • Renthal W, Kumar A, Xiao G, Wilkinson M, Covington HE 3rd, Maze I, Sikder D, Robison AJ, LaPlant Q, Dietz DM, Russo SJ, Vialou V, Chakravarty S, Kodadek TJ, Stack A, Kabbaj M, Nestler EJ (2009) Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins. Neuron 62:335–348

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Robinson DL, Wightman RM (2007) In: Michael AC, Borland LM (eds) Electrochemical methods for neuroscience

    Google Scholar 

  • Robinson DL, Phillips PE, Budygin EA, Trafton BJ, Garris PA, Wightman RM (2001) Sub-second changes in accumbal dopamine during sexual behavior in male rats. NeuroReport 12:2549–2552

    Article  CAS  PubMed  Google Scholar 

  • Robinson DL, Heien ML, Wightman RM (2002) Frequency of dopamine concentration transients increases in dorsal and ventral striatum of male rats during introduction of conspecifics. J Neurosci Off J Soc Neurosci 22:10477–10486

    CAS  Google Scholar 

  • Robinson DL, Zitzman DL, Smith KJ, Spear LP (2011) Fast dopamine release events in the nucleus accumbens of early adolescent rats. Neuroscience 176:296–307

    Article  CAS  PubMed  Google Scholar 

  • Roitman MF, Wheeler RA, Wightman RM, Carelli RM (2008) Real-time chemical responses in the nucleus accumbens differentiate rewarding and aversive stimuli. Nat Neurosci 11:1376–1377

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Root DH, Mejias-Aponte CA, Qi J, Morales M (2014) Role of glutamatergic projections from ventral tegmental area to lateral habenula in aversive conditioning. J Neurosci 34:13906–13910

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Russo SJ, Nestler EJ (2013) The brain reward circuitry in mood disorders. Nat Rev Neurosci 14:609–625

    Article  CAS  PubMed  Google Scholar 

  • Russo SJ, Wilkinson MB, Mazei-Robison MS, Dietz DM, Maze I, Krishnan V, Renthal W, Graham A, Birnbaum SG, Green TA, Robison B, Lesselyong A, Perrotti LI, Bolanos CA, Kumar A, Clark MS, Neumaier JF, Neve RL, Bhakar AL, Barker PA, Nestler EJ (2009) Nuclear factor kappa B signaling regulates neuronal morphology and cocaine reward. J Neurosci 29:3529–3537

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Russo SJ, Dietz DM, Dumitriu D, Morrison JH, Malenka RC, Nestler EJ (2010) The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens. Trends Neurosci 33:267–276

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sara SJ (2009) The locus coeruleus and noradrenergic modulation of cognition. Nat Rev Neurosci 10:211–223

    Article  CAS  PubMed  Google Scholar 

  • Sartorius A, Henn FA (2007) Deep brain stimulation of the lateral habenula in treatment resistant major depression. Med Hypotheses 69:1305–1308

    Article  PubMed  Google Scholar 

  • Schneider TM, Beynon C, Sartorius A, Unterberg AW, Kiening KL (2013) Deep brain stimulation of the lateral habenular complex in treatment-resistant depression: traps and pitfalls of trajectory choice. Neurosurgery 72, ons184–193; discussion ons193

    Google Scholar 

  • Schnitzer MJ (2002) Biological computation: amazing algorithms. Nature 416:683

    Article  CAS  PubMed  Google Scholar 

  • Schultz W (2007) Multiple dopamine functions at different time courses. Annu Rev Neurosci 30:259–288

    Article  CAS  PubMed  Google Scholar 

  • Schultz W (2016) Dopamine reward prediction-error signalling: a two-component response. Nat Rev Neurosci 17:183–195

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Schweimer JV, Ungless MA (2010) Phasic responses in dorsal raphe serotonin neurons to noxious stimuli. Neuroscience 171:1209–1215

    Article  CAS  PubMed  Google Scholar 

  • Sears RM, Fink AE, Wigestrand MB, Farb CR, de Lecea L, Ledoux JE (2013) Orexin/hypocretin system modulates amygdala-dependent threat learning through the locus coeruleus. Proc Natl Acad Sci U S A 110:20260–20265

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Setlow B, Holland PC, Gallagher M (2002) Disconnection of the basolateral amygdala complex and nucleus accumbens impairs appetitive pavlovian second-order conditioned responses. Behav Neurosci 116:267–275

    Article  PubMed  Google Scholar 

  • Shabel SJ, Janak PH (2009) Substantial similarity in amygdala neuronal activity during conditioned appetitive and aversive emotional arousal. Proc Natl Acad Sci U S A 106:15031–15036

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Shabel SJ, Proulx CD, Trias A, Murphy RT, Malinow R (2012) Input to the lateral habenula from the basal ganglia is excitatory, aversive, and suppressed by serotonin. Neuron 74:475–481

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Shabel SJ, Proulx CD, Piriz J, Malinow R (2014) Mood regulation. GABA/glutamate co-release controls habenula output and is modified by antidepressant treatment. Science 345:1494–1498

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Shansky RM, Hamo C, Hof PR, McEwen BS, Morrison JH (2009) Stress-induced dendritic remodeling in the prefrontal cortex is circuit specific. Cereb Cortex 19:2479–2484

    Article  PubMed  PubMed Central  Google Scholar 

  • Shiflett MW, Balleine BW (2010) At the limbic-motor interface: disconnection of basolateral amygdala from nucleus accumbens core and shell reveals dissociable components of incentive motivation. Eur J Neurosci 32:1735–1743

    Article  PubMed  PubMed Central  Google Scholar 

  • Smith RJ, Lobo MK, Spencer S, Kalivas PW (2013) Cocaine-induced adaptations in D1 and D2 accumbens projection neurons (a dichotomy not necessarily synonymous with direct and indirect pathways). Curr Opin Neurobiol 23:546–552

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Soiza-Reilly M, Commons KG (2014) Unraveling the architecture of the dorsal raphe synaptic neuropil using high-resolution neuroanatomy. Front Neural Circuits 8:105

    Article  PubMed  PubMed Central  Google Scholar 

  • Stamatakis AM, Stuber GD (2012) Activation of lateral habenula inputs to the ventral midbrain promotes behavioral avoidance. Nat Neurosci 15:1105–1107

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Stamatakis AM, Jennings JH, Ung RL, Blair GA, Weinberg RJ, Neve RL, Boyce F, Mattis J, Ramakrishnan C, Deisseroth K, Stuber GD (2013) A unique population of ventral tegmental area neurons inhibits the lateral habenula to promote reward. Neuron 80:1039–1053

    Article  CAS  PubMed  Google Scholar 

  • Stuber GD, Hnasko TS, Britt JP, Edwards RH, Bonci A (2010) Dopaminergic terminals in the nucleus accumbens but not the dorsal striatum corelease glutamate. J Neurosci 30:8229–8233

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Stuber GD, Sparta DR, Stamatakis AM, van Leeuwen WA, Hardjoprajitno JE, Cho S, Tye KM, Kempadoo KA, Zhang F, Deisseroth K, Bonci A (2011) Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking. Nature 475:377–380

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Takamori S (2006) VGLUTs: ‘exciting’ times for glutamatergic research? Neurosci Res 55:343–351

    Article  CAS  PubMed  Google Scholar 

  • Tan KR, Yvon C, Turiault M, Mirzabekov JJ, Doehner J, Labouebe G, Deisseroth K, Tye KM,  Lüscher C (2012) GABA neurons of the VTA drive conditioned place aversion. Neuron 73:1173–1183

    Google Scholar 

  • Tecuapetla F, Patel JC, Xenias H, English D, Tadros I, Shah F, Berlin J, Deisseroth K, Rice ME, Tepper JM, Koos T (2010) Glutamatergic signaling by mesolimbic dopamine neurons in the nucleus accumbens. J Neurosci 30:7105–7110

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Thompson SM, Kallarackal AJ, Kvarta MD, Van Dyke AM, LeGates TA, Cai X (2015) An excitatory synapse hypothesis of depression. Trends Neurosci 38:279–294

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tsai HC, Zhang F, Adamantidis A, Stuber GD, Bonci A, de Lecea L, Deisseroth K (2009) Phasic firing in dopaminergic neurons is sufficient for behavioral conditioning. Science 324:1080–1084

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tye KM, Stuber GD, de Ridder B, Bonci A, Janak PH (2008) Rapid strengthening of thalamo-amygdala synapses mediates cue-reward learning. Nature 453:1253–1257

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tye KM, Prakash R, Kim SY, Fenno LE, Grosenick L, Zarabi H, Thompson KR, Gradinaru V, Ramakrishnan C, Deisseroth K (2011) Amygdala circuitry mediating reversible and bidirectional control of anxiety. Nature 471:358–362

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tye KM, Mirzabekov JJ, Warden MR, Ferenczi EA, Tsai HC, Finkelstein J, Kim SY, Adhikari A, Thompson KR, Andalman AS, Gunaydin LA, Witten IB, Deisseroth K (2013) Dopamine neurons modulate neural encoding and expression of depression-related behaviour. Nature 493:537–541

    Article  CAS  PubMed  Google Scholar 

  • Ungless MA, Grace AA (2012) Are you or aren’t you? Challenges associated with physiologically identifying dopamine neurons. Trends Neurosci 35:422–430

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ungless MA, Whistler JL, Malenka RC, Bonci A (2001) Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons. Nature 411:583–587

    Article  CAS  PubMed  Google Scholar 

  • Vaaga CE, Borisovska M, Westbrook GL (2014) Dual-transmitter neurons: functional implications of co-release and co-transmission. Curr Opin Neurobiol 29:25–32

    Article  CAS  PubMed  Google Scholar 

  • Valenti O, Gill KM, Grace AA (2012) Different stressors produce excitation or inhibition of mesolimbic dopamine neuron activity: response alteration by stress pre-exposure. Eur J Neurosci 35:1312–1321

    Article  PubMed  PubMed Central  Google Scholar 

  • Vasudeva RK, Lin RC, Simpson KL, Waterhouse BD (2011) Functional organization of the dorsal raphe efferent system with special consideration of nitrergic cell groups. J Chem Neuroanat 41:281–293

    Article  CAS  PubMed  Google Scholar 

  • Vialou V, Robison AJ, Laplant QC, Covington HE 3rd, Dietz DM, Ohnishi YN, Mouzon E, Rush AJ 3rd, Watts EL, Wallace DL, Iniguez SD, Ohnishi YH, Steiner MA, Warren BL, Krishnan V, Bolanos CA, Neve RL, Ghose S, Berton O, Tamminga CA, Nestler EJ (2010) DeltaFosB in brain reward circuits mediates resilience to stress and antidepressant responses. Nat Neurosci 13:745–752

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Walker DL, Davis M (2008) Role of the extended amygdala in short-duration versus sustained fear: a tribute to Dr. Lennart Heimer. Brain Struct Funct 213:29–42

    Article  PubMed  Google Scholar 

  • Walker DL, Miles LA, Davis M (2009) Selective participation of the bed nucleus of the stria terminalis and CRF in sustained anxiety-like versus phasic fear-like responses. Prog Neuropsychopharmacol Biol Psychiatry 33:1291–1308

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Walsh JJ, Han MH (2014) The heterogeneity of ventral tegmental area neurons: projection functions in a mood-related context. Neuroscience 282:101–108

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Walsh JJ, Friedman AK, Sun H, Heller EA, Ku SM, Juarez B, Burnham VL, Mazei-Robison MS, Ferguson D, Golden SA, Koo JW, Chaudhury D, Christoffel DJ, Pomeranz L, Friedman JM, Russo SJ, Nestler EJ, Han MH (2014) Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway. Nat Neurosci 17:27–29

    Article  CAS  PubMed  Google Scholar 

  • Wanat MJ, Hopf FW, Stuber GD, Phillips PE, Bonci A (2008) Corticotropin-releasing factor increases mouse ventral tegmental area dopamine neuron firing through a protein kinase C-dependent enhancement of Ih. J Physiol 586:2157–2170

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang RY, Aghajanian GK (1977) Inhibiton of neurons in the amygdala by dorsal raphe stimulation: mediation through a direct serotonergic pathway. Brain Res 120:85–102

    Article  CAS  PubMed  Google Scholar 

  • Wang HL, Morales M (2009) Pedunculopontine and laterodorsal tegmental nuclei contain distinct populations of cholinergic, glutamatergic and GABAergic neurons in the rat. Eur J Neurosci 29:340–358

    Article  PubMed  Google Scholar 

  • Wenzel JM, Rauscher NA, Cheer JF, Oleson EB (2015) A role for phasic dopamine release within the nucleus accumbens in encoding aversion: a review of the neurochemical literature. ACS Chem Neurosci 6:16–26

    Article  CAS  PubMed  Google Scholar 

  • West AR, Grace AA (2002) Opposite influences of endogenous dopamine D1 and D2 receptor activation on activity states and electrophysiological properties of striatal neurons: studies combining in vivo intracellular recordings and reverse microdialysis. J Neurosci 22:294–304

    CAS  PubMed  Google Scholar 

  • West CH, Ritchie JC, Boss-Williams KA, Weiss JM (2009) Antidepressant drugs with differing pharmacological actions decrease activity of locus coeruleus neurons. Int J Neuropsychopharmacol 12:627–641

    Article  CAS  PubMed  Google Scholar 

  • Xiao C, Cho JR, Zhou C, Treweek JB, Chan K, McKinney SL, Yang B, Gradinaru V (2016) Cholinergic mesopontine signals govern locomotion and reward through dissociable midbrain pathways. Neuron 90:333–347

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yang LM, Hu B, Xia YH, Zhang BL, Zhao H (2008) Lateral habenula lesions improve the behavioral response in depressed rats via increasing the serotonin level in dorsal raphe nucleus. Behav Brain Res 188:84–90

    Article  PubMed  Google Scholar 

  • Zarate C, Duman RS, Liu G, Sartori S, Quiroz J, Murck H (2013) New paradigms for treatment-resistant depression. Ann N Y Acad Sci 1292:21–31

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhang J, Shapiro MS (2012) Activity-dependent transcriptional regulation of M-Type (Kv7) K(+) channels by AKAP79/150-mediated NFAT actions. Neuron 76:1133–1146

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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  1. Department of Biology, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates

    He Liu & Dipesh Chaudhury

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    Arzu Çelik

  2. Fachbereich Biologie, Chemie, Pharmazie, Institut für Biologie—Neurobiologie, Freie Universität Berlin, Berlin, Germany

    Mathias F. Wernet

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Liu, H., Chaudhury, D. (2017). Understanding Mood Disorders Using Electrophysiology and Circuit Breaking. In: Çelik, A., Wernet, M. (eds) Decoding Neural Circuit Structure and Function. Springer, Cham. https://doi.org/10.1007/978-3-319-57363-2_14

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