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Cell Therapy pp 19–52Cite as

Considerations for Successful Encapsulated β-Cell Therapy

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Part of the book series: Molecular and Translational Medicine ((MOLEMED))

Abstract

Encapsulated beta cell therapy for the treatment of type 1 diabetes remains at the forefront of biomaterials research. With recent success in generating glucoresponsive stem cell-derived β-cells, there is a renewed sense of promise in the field driven by the quality and quantity of available cell sources. Several strategies are in development that address the failure modes associated with encapsulation including hypoxia within the encapsulated biomass, foreign body response against the materials that make up the encapsulation device, poor or declining insulin flux, and membrane selectivity against elements of the immune system. This review chapter highlights some of the key innovations in each of these areas of beta cell encapsulation and provides context as stem cell strategies advance to the clinic.

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Authors and Affiliations

  1. VP Delivery R&D, Semma Therapeutics, 117 Chapman St., Providence, RI, 02905, USA

    Christopher G. Thanos Ph.D.

  2. Section on Immunobiology, Joslin Diabetes Center, One Joslin Place, Boston, MA, 02215, USA

    Jason L. Gaglia M.D., M.M.Sc.

  3. VP Cell Biology R&D, Semma Therapeutics, 450 Kendall St, Cambridge, MA, 02142, USA

    Felicia W. Pagliuca Ph.D.

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  1. Christopher G. Thanos Ph.D.
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  2. Jason L. Gaglia M.D., M.M.Sc.
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  3. Felicia W. Pagliuca Ph.D.
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Correspondence to Christopher G. Thanos Ph.D. .

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    Dwaine F. Emerich

  2. Paseo de la Universidad 7, Vitoria-Gasteiz, Spain

    Gorka Orive

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Thanos, C.G., Gaglia, J.L., Pagliuca, F.W. (2017). Considerations for Successful Encapsulated β-Cell Therapy. In: Emerich, D., Orive, G. (eds) Cell Therapy. Molecular and Translational Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-57153-9_2

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