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Considerations for Successful Encapsulated β-Cell Therapy

  • Christopher G. ThanosEmail author
  • Jason L. Gaglia
  • Felicia W. Pagliuca
Chapter
Part of the Molecular and Translational Medicine book series (MOLEMED)

Abstract

Encapsulated beta cell therapy for the treatment of type 1 diabetes remains at the forefront of biomaterials research. With recent success in generating glucoresponsive stem cell-derived β-cells, there is a renewed sense of promise in the field driven by the quality and quantity of available cell sources. Several strategies are in development that address the failure modes associated with encapsulation including hypoxia within the encapsulated biomass, foreign body response against the materials that make up the encapsulation device, poor or declining insulin flux, and membrane selectivity against elements of the immune system. This review chapter highlights some of the key innovations in each of these areas of beta cell encapsulation and provides context as stem cell strategies advance to the clinic.

Keywords

Macrodevice Encapsulation Membrane Islet β-cell Stem cell Diabetes Immunoprotection Inflammation Biomaterials 

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Christopher G. Thanos
    • 1
    Email author
  • Jason L. Gaglia
    • 2
  • Felicia W. Pagliuca
    • 3
  1. 1.VP Delivery R&D, Semma TherapeuticsProvidenceUSA
  2. 2.Section on ImmunobiologyJoslin Diabetes CenterBostonUSA
  3. 3.VP Cell Biology R&D, Semma TherapeuticsCambridgeUSA

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